Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century
Abstract Background Cancers of the head and neck (HN) are heterogeneous tumors with incidence rates varying globally. In Northern Europe oral and oropharyngeal cancers are the most common individual types. Survival for HN varies by individual tumor type but for most of them survival trends are not w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6867 |
| _version_ | 1797277132605358080 |
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| author | Frantisek Zitricky Anni I. Koskinen Otto Hemminki Asta Försti Akseli Hemminki Kari Hemminki |
| author_facet | Frantisek Zitricky Anni I. Koskinen Otto Hemminki Asta Försti Akseli Hemminki Kari Hemminki |
| author_sort | Frantisek Zitricky |
| collection | DOAJ |
| description | Abstract Background Cancers of the head and neck (HN) are heterogeneous tumors with incidence rates varying globally. In Northern Europe oral and oropharyngeal cancers are the most common individual types. Survival for HN varies by individual tumor type but for most of them survival trends are not well known over extended periods of time. Methods Data for a retrospective survival study were obtained for Danish, Finnish, Norwegian, and Swedish patients from the NORDCAN database from 1971 to 2020. Relative 1‐ and 5‐year survival rates and 5/1‐year conditional survival for years 2–5 were calculated. Results Both 1‐ and 5‐year survival improved for all HN cancers but only marginally for laryngeal cancer. For the other cancers a 50‐year increase in 5‐year survival was about 30% units for nasopharyngeal and oropharyngeal cancers, 20% units for oral cancer and somewhat less for hypopharyngeal cancer. Conclusions 5‐year survival reached about 65% for all HN cancers, except for hypopharyngeal cancer (30%). Human papilloma virus infection is becoming a dominant risk factor for the rapidly increasing oropharyngeal cancer, the prevention of which needs to emphasize oral sex as a route of infection. |
| first_indexed | 2024-03-07T15:43:16Z |
| format | Article |
| id | doaj.art-1d6dae5055bd49eaa77262308b4cfbbc |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-07T15:43:16Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-1d6dae5055bd49eaa77262308b4cfbbc2024-03-05T06:22:52ZengWileyCancer Medicine2045-76342024-01-01131n/an/a10.1002/cam4.6867Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half centuryFrantisek Zitricky0Anni I. Koskinen1Otto Hemminki2Asta Försti3Akseli Hemminki4Kari Hemminki5Faculty of Medicine and Biomedical Center in Pilsen Charles University in Prague Pilsen Czech RepublicDepartment of Otorhinolaryngology‐ Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki FinlandDepartment of Urology Helsinki University Hospital and University of Helsinki Helsinki FinlandHopp Children's Cancer Center (KiTZ) Heidelberg GermanyCancer Gene Therapy Group, Translational Immunology Research Program University of Helsinki Helsinki FinlandFaculty of Medicine and Biomedical Center in Pilsen Charles University in Prague Pilsen Czech RepublicAbstract Background Cancers of the head and neck (HN) are heterogeneous tumors with incidence rates varying globally. In Northern Europe oral and oropharyngeal cancers are the most common individual types. Survival for HN varies by individual tumor type but for most of them survival trends are not well known over extended periods of time. Methods Data for a retrospective survival study were obtained for Danish, Finnish, Norwegian, and Swedish patients from the NORDCAN database from 1971 to 2020. Relative 1‐ and 5‐year survival rates and 5/1‐year conditional survival for years 2–5 were calculated. Results Both 1‐ and 5‐year survival improved for all HN cancers but only marginally for laryngeal cancer. For the other cancers a 50‐year increase in 5‐year survival was about 30% units for nasopharyngeal and oropharyngeal cancers, 20% units for oral cancer and somewhat less for hypopharyngeal cancer. Conclusions 5‐year survival reached about 65% for all HN cancers, except for hypopharyngeal cancer (30%). Human papilloma virus infection is becoming a dominant risk factor for the rapidly increasing oropharyngeal cancer, the prevention of which needs to emphasize oral sex as a route of infection.https://doi.org/10.1002/cam4.6867conditional survivalhuman papilloma virusoral cancerpharyngeal cancer |
| spellingShingle | Frantisek Zitricky Anni I. Koskinen Otto Hemminki Asta Försti Akseli Hemminki Kari Hemminki Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century Cancer Medicine conditional survival human papilloma virus oral cancer pharyngeal cancer |
| title | Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century |
| title_full | Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century |
| title_fullStr | Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century |
| title_full_unstemmed | Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century |
| title_short | Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century |
| title_sort | survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the nordic countries through a half century |
| topic | conditional survival human papilloma virus oral cancer pharyngeal cancer |
| url | https://doi.org/10.1002/cam4.6867 |
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