Florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy: Report of two cases
Bioabsorbable hemostatic agents like oxidized regenerated cellulose (ORC) are widely used in surgical practice. Rarely, adverse events due to retained ORC may occur and can pose a diagnostic dilemma. The unique tissue response to ORC may be misdiagnosed as signet ring type of adenocarcinoma. This ar...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=4;spage=620;epage=622;aulast=Jacob |
| _version_ | 1818381983031492608 |
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| author | Sunitha Jacob Sudharani Bairraju |
| author_facet | Sunitha Jacob Sudharani Bairraju |
| author_sort | Sunitha Jacob |
| collection | DOAJ |
| description | Bioabsorbable hemostatic agents like oxidized regenerated cellulose (ORC) are widely used in surgical practice. Rarely, adverse events due to retained ORC may occur and can pose a diagnostic dilemma. The unique tissue response to ORC may be misdiagnosed as signet ring type of adenocarcinoma. This article aims to highlight this rare phenomenon. We report two such cases involving the ovaries. Both the patients presented with ovarian cysts and tubo-ovarian adhesions 1–2 years following surgery for benign ovarian pathology. The present biopsies were featured by sheets of large cells with abundant vacuolated cytoplasm and often small peripherally displaced nuclei having “signet ring” appearance. These cells were negative for pan-cytokeratin and strongly positive for CD68, indicating the histiocytic nature of the cells. It was confirmed that in both the patients, at the time of the initial surgeries, hemostasis was ensured by packing with ORC. |
| first_indexed | 2024-12-14T02:43:14Z |
| format | Article |
| id | doaj.art-1d6df9ff36a04ffdb7d5ddc60bf8f9d3 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-14T02:43:14Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-1d6df9ff36a04ffdb7d5ddc60bf8f9d32022-12-21T23:19:58ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292020-01-0163462062210.4103/IJPM.IJPM_688_19Florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy: Report of two casesSunitha JacobSudharani BairrajuBioabsorbable hemostatic agents like oxidized regenerated cellulose (ORC) are widely used in surgical practice. Rarely, adverse events due to retained ORC may occur and can pose a diagnostic dilemma. The unique tissue response to ORC may be misdiagnosed as signet ring type of adenocarcinoma. This article aims to highlight this rare phenomenon. We report two such cases involving the ovaries. Both the patients presented with ovarian cysts and tubo-ovarian adhesions 1–2 years following surgery for benign ovarian pathology. The present biopsies were featured by sheets of large cells with abundant vacuolated cytoplasm and often small peripherally displaced nuclei having “signet ring” appearance. These cells were negative for pan-cytokeratin and strongly positive for CD68, indicating the histiocytic nature of the cells. It was confirmed that in both the patients, at the time of the initial surgeries, hemostasis was ensured by packing with ORC.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=4;spage=620;epage=622;aulast=Jacobhemostatic agentsovaryoxidized regenerated cellulose |
| spellingShingle | Sunitha Jacob Sudharani Bairraju Florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy: Report of two cases Indian Journal of Pathology and Microbiology hemostatic agents ovary oxidized regenerated cellulose |
| title | Florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy: Report of two cases |
| title_full | Florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy: Report of two cases |
| title_fullStr | Florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy: Report of two cases |
| title_full_unstemmed | Florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy: Report of two cases |
| title_short | Florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy: Report of two cases |
| title_sort | florid histiocytic reaction to oxidized cellulose masquerading as ovarian malignancy report of two cases |
| topic | hemostatic agents ovary oxidized regenerated cellulose |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=4;spage=620;epage=622;aulast=Jacob |
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