TARGETgene: a tool for identification of potential therapeutic targets in cancer.
The vast array of in silico resources and data of high throughput profiling currently available in life sciences research offer the possibility of aiding cancer gene and drug discovery process. Here we propose to take advantage of these resources to develop a tool, TARGETgene, for efficiently identi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3432038?pdf=render |
| _version_ | 1811269551546957824 |
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| author | Chia-Chin Wu David D'Argenio Shahab Asgharzadeh Timothy Triche |
| author_facet | Chia-Chin Wu David D'Argenio Shahab Asgharzadeh Timothy Triche |
| author_sort | Chia-Chin Wu |
| collection | DOAJ |
| description | The vast array of in silico resources and data of high throughput profiling currently available in life sciences research offer the possibility of aiding cancer gene and drug discovery process. Here we propose to take advantage of these resources to develop a tool, TARGETgene, for efficiently identifying mutation drivers, possible therapeutic targets, and drug candidates in cancer. The simple graphical user interface enables rapid, intuitive mapping and analysis at the systems level. Users can find, select, and explore identified target genes and compounds of interest (e.g., novel cancer genes and their enriched biological processes), and validate predictions using user-defined benchmark genes (e.g., target genes detected in RNAi screens) and curated cancer genes via TARGETgene. The high-level capabilities of TARGETgene are also demonstrated through two applications in this paper. The predictions in these two applications were then satisfactorily validated by several ways, including known cancer genes, results of RNAi screens, gene function annotations, and target genes of drugs that have been used or in clinical trial in cancer treatments. TARGETgene is freely available from the Biomedical Simulations Resource web site (http://bmsr.usc.edu/Software/TARGET/TARGET.html). |
| first_indexed | 2024-04-12T21:43:59Z |
| format | Article |
| id | doaj.art-1d6e2227ab044001a2de226438f4f592 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T21:43:59Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1d6e2227ab044001a2de226438f4f5922022-12-22T03:15:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4330510.1371/journal.pone.0043305TARGETgene: a tool for identification of potential therapeutic targets in cancer.Chia-Chin WuDavid D'ArgenioShahab AsgharzadehTimothy TricheThe vast array of in silico resources and data of high throughput profiling currently available in life sciences research offer the possibility of aiding cancer gene and drug discovery process. Here we propose to take advantage of these resources to develop a tool, TARGETgene, for efficiently identifying mutation drivers, possible therapeutic targets, and drug candidates in cancer. The simple graphical user interface enables rapid, intuitive mapping and analysis at the systems level. Users can find, select, and explore identified target genes and compounds of interest (e.g., novel cancer genes and their enriched biological processes), and validate predictions using user-defined benchmark genes (e.g., target genes detected in RNAi screens) and curated cancer genes via TARGETgene. The high-level capabilities of TARGETgene are also demonstrated through two applications in this paper. The predictions in these two applications were then satisfactorily validated by several ways, including known cancer genes, results of RNAi screens, gene function annotations, and target genes of drugs that have been used or in clinical trial in cancer treatments. TARGETgene is freely available from the Biomedical Simulations Resource web site (http://bmsr.usc.edu/Software/TARGET/TARGET.html).http://europepmc.org/articles/PMC3432038?pdf=render |
| spellingShingle | Chia-Chin Wu David D'Argenio Shahab Asgharzadeh Timothy Triche TARGETgene: a tool for identification of potential therapeutic targets in cancer. PLoS ONE |
| title | TARGETgene: a tool for identification of potential therapeutic targets in cancer. |
| title_full | TARGETgene: a tool for identification of potential therapeutic targets in cancer. |
| title_fullStr | TARGETgene: a tool for identification of potential therapeutic targets in cancer. |
| title_full_unstemmed | TARGETgene: a tool for identification of potential therapeutic targets in cancer. |
| title_short | TARGETgene: a tool for identification of potential therapeutic targets in cancer. |
| title_sort | targetgene a tool for identification of potential therapeutic targets in cancer |
| url | http://europepmc.org/articles/PMC3432038?pdf=render |
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