Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens?
The occurrence and spreading of multidrug resistance in bacterial pathogens represent one of the greatest challenges of the 21st century. With fewer and fewer new antibiotics in development, novel and unconventional concepts in drug development and formulation need to be explored to overcome the glo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-04-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202200134 |
| _version_ | 1797776425545105408 |
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| author | Bhanu Kiran Pothineni Adrian Keller |
| author_facet | Bhanu Kiran Pothineni Adrian Keller |
| author_sort | Bhanu Kiran Pothineni |
| collection | DOAJ |
| description | The occurrence and spreading of multidrug resistance in bacterial pathogens represent one of the greatest challenges of the 21st century. With fewer and fewer new antibiotics in development, novel and unconventional concepts in drug development and formulation need to be explored to overcome the global antibiotics crisis. Biomedical nanotechnology offers promising strategies for the reformulation of established antibiotics in such a way that they regain their activity against resistant pathogens. Herein, promising developments aimed at the synthesis of potent nanoparticle‐based formulations of glycopeptide antibiotics are reviewed. While glycopeptide antibiotics such as vancomycin and teicoplanin are widely used as drugs of last resort against Gram‐positive pathogens such as methicillin‐resistant Staphylococcus aureus (MRSA), bacterial resistance against these drugs is spreading. However, inhibiting cell wall synthesis via binding to cell wall precursor peptidoglycans, glycopeptide antibiotics exhibit a unique mode of action that renders them particularly promising candidates for nanoparticle‐based formulations with the ability to overcome glycopeptide antibiotic resistance. Herein, different formulation concepts based on multivalent presentation and encapsulation are introduced, different synthesis and conjugation strategies are discussed, and an attempt is made to rationalize their effects on the antibacterial activity of the resulting nanoparticle formulations. |
| first_indexed | 2024-03-12T22:49:48Z |
| format | Article |
| id | doaj.art-1d6e938f08cc42468471f2cf6faedaff |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-03-12T22:49:48Z |
| publishDate | 2023-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-1d6e938f08cc42468471f2cf6faedaff2023-07-20T12:56:22ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-04-0134n/an/a10.1002/anbr.202200134Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens?Bhanu Kiran Pothineni0Adrian Keller1Technical and Macromolecular Chemistry Paderborn University Warburger Str. 100 33098 Paderborn GermanyTechnical and Macromolecular Chemistry Paderborn University Warburger Str. 100 33098 Paderborn GermanyThe occurrence and spreading of multidrug resistance in bacterial pathogens represent one of the greatest challenges of the 21st century. With fewer and fewer new antibiotics in development, novel and unconventional concepts in drug development and formulation need to be explored to overcome the global antibiotics crisis. Biomedical nanotechnology offers promising strategies for the reformulation of established antibiotics in such a way that they regain their activity against resistant pathogens. Herein, promising developments aimed at the synthesis of potent nanoparticle‐based formulations of glycopeptide antibiotics are reviewed. While glycopeptide antibiotics such as vancomycin and teicoplanin are widely used as drugs of last resort against Gram‐positive pathogens such as methicillin‐resistant Staphylococcus aureus (MRSA), bacterial resistance against these drugs is spreading. However, inhibiting cell wall synthesis via binding to cell wall precursor peptidoglycans, glycopeptide antibiotics exhibit a unique mode of action that renders them particularly promising candidates for nanoparticle‐based formulations with the ability to overcome glycopeptide antibiotic resistance. Herein, different formulation concepts based on multivalent presentation and encapsulation are introduced, different synthesis and conjugation strategies are discussed, and an attempt is made to rationalize their effects on the antibacterial activity of the resulting nanoparticle formulations.https://doi.org/10.1002/anbr.202200134antimicrobial resistanceencapsulationmultivalencynanoparticlestargetingteicoplanin |
| spellingShingle | Bhanu Kiran Pothineni Adrian Keller Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens? Advanced NanoBiomed Research antimicrobial resistance encapsulation multivalency nanoparticles targeting teicoplanin |
| title | Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens? |
| title_full | Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens? |
| title_fullStr | Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens? |
| title_full_unstemmed | Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens? |
| title_short | Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens? |
| title_sort | nanoparticle based formulations of glycopeptide antibiotics a means for overcoming vancomycin resistance in bacterial pathogens |
| topic | antimicrobial resistance encapsulation multivalency nanoparticles targeting teicoplanin |
| url | https://doi.org/10.1002/anbr.202200134 |
| work_keys_str_mv | AT bhanukiranpothineni nanoparticlebasedformulationsofglycopeptideantibioticsameansforovercomingvancomycinresistanceinbacterialpathogens AT adriankeller nanoparticlebasedformulationsofglycopeptideantibioticsameansforovercomingvancomycinresistanceinbacterialpathogens |