A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma
Feline squamous cell carcinoma (SCC) is currently treated with surgery, radiation therapy and electrochemotherapy (ECT). Both the efficacy and/or safety of ECT were evaluated as a sole therapy with bleomycin to treat feline nasal planum SCC (npSCC). Sixty-one cats were enrolled. Local treatment resp...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/8/3/53 |
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| author | Petra Simčič Alessio Pierini George Lubas Ron Lowe Valentina Granziera Raimondo Tornago Fabio Valentini Giulia Alterio Matteo Cochi Marcelo Monte Mor Rangel Krishna Duro de Oliveira Jennifer Ostrand Freytag Priscila Gil Quadros Enrico Sponza Francesca Gattino Joseph A. Impellizeri Filippo Torrigiani |
| author_facet | Petra Simčič Alessio Pierini George Lubas Ron Lowe Valentina Granziera Raimondo Tornago Fabio Valentini Giulia Alterio Matteo Cochi Marcelo Monte Mor Rangel Krishna Duro de Oliveira Jennifer Ostrand Freytag Priscila Gil Quadros Enrico Sponza Francesca Gattino Joseph A. Impellizeri Filippo Torrigiani |
| author_sort | Petra Simčič |
| collection | DOAJ |
| description | Feline squamous cell carcinoma (SCC) is currently treated with surgery, radiation therapy and electrochemotherapy (ECT). Both the efficacy and/or safety of ECT were evaluated as a sole therapy with bleomycin to treat feline nasal planum SCC (npSCC). Sixty-one cats were enrolled. Local treatment response was evaluated as complete remission (CR), partial remission (PR) or stable disease (SD). Recurrence rate (RR), disease-free interval (DFI) and progression free survival (PFS) were calculated. A six-point scale was used for ECT toxicity. The median tumor size was 1.5 cm. CR was achieved in 65.6% of cases, PR in 31.1% and SD in 3.3%. The overall response rate was 96.7%, RR was 22.5%, median DFI was 136 days, and median PFS was 65.5 days. ECT toxicity was ≤2 in 51% of cats. Tumor recurrence/progression (<i>p</i> = 0.014) and local treatment response (PR: <i>p</i> < 0.001; SD: <i>p</i> < 0.001) influenced survival time. Cats with toxicity >2 showed a higher probability of tumor recurrence/progression. Tumor-related death was higher in cats with PR (<i>p</i> < 0.001) and recurrence/progression (<i>p</i> = 0.002), in ECT treatment with 1 Hz (<i>p</i> = 0.035) and 1200 V/cm (<i>p</i> = 0.011) or 1300 V/cm (<i>p</i> = 0.016). Tumor size influenced local treatment response (<i>p</i> = 0.008) and toxicity (<i>p</i> < 0.001). ECT is an effective treatment for feline npSCCs and should be considered as the first-line procedure for low-stage tumors. |
| first_indexed | 2024-03-10T13:01:53Z |
| format | Article |
| id | doaj.art-1d70b4f37f2b4ca3a2851db189295200 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T13:01:53Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-1d70b4f37f2b4ca3a2851db1892952002023-11-21T11:26:35ZengMDPI AGVeterinary Sciences2306-73812021-03-01835310.3390/vetsci8030053A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell CarcinomaPetra Simčič0Alessio Pierini1George Lubas2Ron Lowe3Valentina Granziera4Raimondo Tornago5Fabio Valentini6Giulia Alterio7Matteo Cochi8Marcelo Monte Mor Rangel9Krishna Duro de Oliveira10Jennifer Ostrand Freytag11Priscila Gil Quadros12Enrico Sponza13Francesca Gattino14Joseph A. Impellizeri15Filippo Torrigiani16Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyPetCancerVet, 61 Wetherby Road, Knaresborough, North Yorkshire HG5 8LH, UKPetCancerVet, 61 Wetherby Road, Knaresborough, North Yorkshire HG5 8LH, UKMeranese Veterinary Centre, Via J. Speckbacher, 15/B, 39012 Merano, ItalyVia Marco Cornelio Cetego 20, 00177 Rome, ItalyVia Marco Cornelio Cetego 20, 00177 Rome, ItalyVia Marco Cornelio Cetego 20, 00177 Rome, ItalyVet Câncer—Animal Oncology and Pathology, AL Jauaperi, 732 Moema, São Paulo, SP 04523-013, BrazilVet Câncer—Animal Oncology and Pathology, AL Jauaperi, 732 Moema, São Paulo, SP 04523-013, BrazilVet Câncer—Animal Oncology and Pathology, AL Jauaperi, 732 Moema, São Paulo, SP 04523-013, BrazilVet Câncer—Animal Oncology and Pathology, AL Jauaperi, 732 Moema, São Paulo, SP 04523-013, BrazilVeterinary Facility Dr. Enrico Sponza, Via Pra’ 39/r, 16157 Genova, ItalyVeterinary Facility Dr. Enrico Sponza, Via Pra’ 39/r, 16157 Genova, ItalyVeterinary Oncology Services, PLLC at Guardian Veterinary Specialists, Brewster, NY 10509, USADepartment of Comparative Biomedicine and Food Science, University of Padova, Viale dell’Università 16, 35020 Legnaro, ItalyFeline squamous cell carcinoma (SCC) is currently treated with surgery, radiation therapy and electrochemotherapy (ECT). Both the efficacy and/or safety of ECT were evaluated as a sole therapy with bleomycin to treat feline nasal planum SCC (npSCC). Sixty-one cats were enrolled. Local treatment response was evaluated as complete remission (CR), partial remission (PR) or stable disease (SD). Recurrence rate (RR), disease-free interval (DFI) and progression free survival (PFS) were calculated. A six-point scale was used for ECT toxicity. The median tumor size was 1.5 cm. CR was achieved in 65.6% of cases, PR in 31.1% and SD in 3.3%. The overall response rate was 96.7%, RR was 22.5%, median DFI was 136 days, and median PFS was 65.5 days. ECT toxicity was ≤2 in 51% of cats. Tumor recurrence/progression (<i>p</i> = 0.014) and local treatment response (PR: <i>p</i> < 0.001; SD: <i>p</i> < 0.001) influenced survival time. Cats with toxicity >2 showed a higher probability of tumor recurrence/progression. Tumor-related death was higher in cats with PR (<i>p</i> < 0.001) and recurrence/progression (<i>p</i> = 0.002), in ECT treatment with 1 Hz (<i>p</i> = 0.035) and 1200 V/cm (<i>p</i> = 0.011) or 1300 V/cm (<i>p</i> = 0.016). Tumor size influenced local treatment response (<i>p</i> = 0.008) and toxicity (<i>p</i> < 0.001). ECT is an effective treatment for feline npSCCs and should be considered as the first-line procedure for low-stage tumors.https://www.mdpi.com/2306-7381/8/3/53felinesquamous cell carcinomanasal planumelectrochemotherapybleomycintoxicity |
| spellingShingle | Petra Simčič Alessio Pierini George Lubas Ron Lowe Valentina Granziera Raimondo Tornago Fabio Valentini Giulia Alterio Matteo Cochi Marcelo Monte Mor Rangel Krishna Duro de Oliveira Jennifer Ostrand Freytag Priscila Gil Quadros Enrico Sponza Francesca Gattino Joseph A. Impellizeri Filippo Torrigiani A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma Veterinary Sciences feline squamous cell carcinoma nasal planum electrochemotherapy bleomycin toxicity |
| title | A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma |
| title_full | A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma |
| title_fullStr | A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma |
| title_full_unstemmed | A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma |
| title_short | A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma |
| title_sort | retrospective multicentric study of electrochemotherapy in the treatment of feline nasal planum squamous cell carcinoma |
| topic | feline squamous cell carcinoma nasal planum electrochemotherapy bleomycin toxicity |
| url | https://www.mdpi.com/2306-7381/8/3/53 |
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