Role of monoubiquitylation on the control of IκBα degradation and NF-κB activity.

Role of monoubiquitylation on the control of IκBα degradation and NF-κB activity.

The NF-κB pathway is regulated by multiple post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. Many of these modifications act on the natural inhibitor IκBα modulating its capacity to control signal-mediated NF-κB activity. While the canonical pathway involvin...

Full description

Bibliographic Details
Main Authors:	Elisa Da Silva-Ferrada, Mónica Torres-Ramos, Fabienne Aillet, Michela Campagna, Carlos Matute, Carmen Rivas, Manuel S Rodríguez, Valérie Lang
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3192046?pdf=render

Similar Items

Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity.
by: Fabienne Aillet, et al.
Published: (2012-01-01)

Cadmium induced immunosuppression through TLR-IκBα-NFκB signaling by promoting autophagic degradation
by: Jie Gu, et al.
Published: (2023-07-01)

Beyond NF-κB activation: nuclear functions of IκB kinase α
by: Huang Wei-Chien, et al.
Published: (2013-01-01)

Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice.
by: Sanjeev Shukla, et al.
Published: (2015-01-01)

Single TNF<it>α </it>trimers mediating NF-<it>κ</it>B activation: stochastic robustness of NF-<it>κ</it>B signaling
by: Paszek Pawel, et al.
Published: (2007-10-01)

Blocking autophagy prevents bortezomib-induced NF-κB activation by reducing I-κBα degradation in lymphoma cells.
by: Li Jia, et al.
Published: (2012-01-01)

NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
by: Lluís Espinosa, et al.
Published: (2021-09-01)

DDRGK1 regulates NF-κB activity by modulating IκBα stability.
by: Peng Xi, et al.
Published: (2013-01-01)

NF-κB and Disease
by: Paola Poma
Published: (2020-12-01)

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
by: Carlota Colomer, et al.
Published: (2017-05-01)

Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
by: Andrew Paul, et al.
Published: (2018-10-01)

Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways
by: Sambucetti Lidia C, et al.
Published: (2005-10-01)

Mimiviruses Interfere With IκBα Degradation
by: Juliana dos Santos Oliveira, et al.
Published: (2022-06-01)

NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
by: Eleanor Jayawant, et al.
Published: (2023-06-01)

Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
by: Hui WANG, et al.
Published: (2019-07-01)

Hypoxia Induced NF-κB
by: Laura D’Ignazio, et al.
Published: (2016-03-01)

NF-κB in Hematological Malignancies
by: Véronique Imbert, et al.
Published: (2017-05-01)

Noncanonical NF-κB in Cancer
by: Matthew Tegowski, et al.
Published: (2018-06-01)

NF-κB Signalling in Glioblastoma
by: Vincent Soubannier, et al.
Published: (2017-06-01)

At the crossroads of SUMO and NF-κB
by: Schmidt Christian, et al.
Published: (2003-11-01)

NF-κB signaling and crosstalk during carcinogenesis
by: Brücher Björn L.D.M., et al.
Published: (2019-01-01)

Beta Adrenergic Receptors Stimulation Attenuates Phosphorylation of NF-κB and IκBα in Hyperglycemic Endothelial Cells
by: Safi, Sher Zaman, et al.
Published: (2018)

The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes
by: Eunju Kim, et al.
Published: (2023-09-01)

Beta Adrenergic Receptors Stimulation Attenuates Phosphorylation of NF-κB and IκBα in Hyperglycemic Endothelial Cells
by: Sher Zaman Safi, et al.
Published: (2018-11-01)

Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
by: Yifan Zhou, et al.
Published: (2020-03-01)

NF-κB Mutations in Germinal Center B-Cell Lymphomas: Relation to NF-κB Function in Normal B Cells
by: Laura Pasqualucci, et al.
Published: (2022-10-01)

NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts
by: Smith, C, et al.
Published: (2001)

Hepatic NF‐κB‐Inducing Kinase and Inhibitor of NF‐κB Kinase Subunit α Promote Liver Oxidative Stress, Ferroptosis, and Liver Injury
by: Xiao Zhong, et al.
Published: (2021-10-01)

Hippo pathway phylogenetics predicts monoubiquitylation of Salvador and Merlin/Nf2.
by: Robert G Wisotzkey, et al.
Published: (2012-01-01)

Effects of Trimetazidine on PDCD4/NF-κB/TNF-α Pathway in Coronary Microembolization
by: Qiang Su, et al.
Published: (2017-06-01)

Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons
by: Noebels Jeffrey L, et al.
Published: (2011-06-01)

Basal shuttle of NF-κB/IκBα in resting T lymphocytes regulates HIV-1 LTR dependent expression
by: Mittelbrunn Maria, et al.
Published: (2007-08-01)

Several Alphaherpesviruses Interact Similarly with the NF-κB Pathway and Suppress NF-κB-Dependent Gene Expression
by: Nicolás Romero, et al.
Published: (2023-08-01)

SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction
by: Hidefumi Fukushima, et al.
Published: (2012-05-01)

The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke
by: Guangyu Xu, et al.
Published: (2024-02-01)

4′,6-Dihydroxy-4-methoxyisoaurone inhibits TNF-α-induced NF-κB activation and expressions of NF-κB-regulated target gene products
by: Juan Ma, et al.
Published: (2016-02-01)

Attribution of NF-κB Activity to CHUK/IKKα-Involved Carcinogenesis
by: Xin Li, et al.
Published: (2021-03-01)

NF-κB is important for TNF-α-induced lipolysis in human adipocytes
by: Laurencikiene Jurga, et al.
Published: (2007-05-01)

Salusin-β not salusin-α promotes vascular inflammation in ApoE-deficient mice via the I-κBα/NF-κB pathway.
by: Cheng-Hua Zhou, et al.
Published: (2014-01-01)

NF-κB: Governing Macrophages in Cancer
by: Jessica Cornice, et al.
Published: (2024-01-01)