Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer?
Gastric cancer is one of the five most common types of cancer worldwide. Due to the heterogeneous course and the involvement of many risk factors, its treatment and diagnosis is an important challenge for modern medicine. Recent studies have emphasized the i role of Toll-like receptors (TLRs) expres...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5824 |
| _version_ | 1797611151697117184 |
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| author | Marek Majewski Kamil Torres Paulina Mertowska Sebastian Mertowski Izabela Korona-Głowniak Jan Korulczyk Witold Zgodziński Ewelina Grywalska |
| author_facet | Marek Majewski Kamil Torres Paulina Mertowska Sebastian Mertowski Izabela Korona-Głowniak Jan Korulczyk Witold Zgodziński Ewelina Grywalska |
| author_sort | Marek Majewski |
| collection | DOAJ |
| description | Gastric cancer is one of the five most common types of cancer worldwide. Due to the heterogeneous course and the involvement of many risk factors, its treatment and diagnosis is an important challenge for modern medicine. Recent studies have emphasized the i role of Toll-like receptors (TLRs) expressed on selected cells of the immune system in the pathogenesis of gastric cancer. The aim of this study was to determine the prevalence of TLR2 on T lymphocytes, B lymphocytes, monocytes, and dendritic cells in patients diagnosed with gastric cancer, with particular emphasis on the stage of the disease. Based on the obtained results, we have shown that patients with gastric cancer are characterized by a higher percentage of all tested populations of peripheral blood immune cells expressing TLR2 in relation to patients from the control group. Moreover, a detailed analysis of the collected results showed a significant link between TLR2 and the stage of the disease. |
| first_indexed | 2024-03-11T06:24:45Z |
| format | Article |
| id | doaj.art-1d756d37211e4538bf515feb800c0337 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:24:45Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1d756d37211e4538bf515feb800c03372023-11-17T11:39:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246582410.3390/ijms24065824Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer?Marek Majewski0Kamil Torres1Paulina Mertowska2Sebastian Mertowski3Izabela Korona-Głowniak4Jan Korulczyk5Witold Zgodziński6Ewelina Grywalska72nd Department of General, Gastrointestinal Surgery and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, 20-081 Lublin, PolandChair and Department of Didactics and Medical Simulation, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, PolandChair and Department of Didactics and Medical Simulation, Medical University of Lublin, 20-093 Lublin, Poland1st Department of General and Transplant Surgery and Clinical Nutrition, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, PolandGastric cancer is one of the five most common types of cancer worldwide. Due to the heterogeneous course and the involvement of many risk factors, its treatment and diagnosis is an important challenge for modern medicine. Recent studies have emphasized the i role of Toll-like receptors (TLRs) expressed on selected cells of the immune system in the pathogenesis of gastric cancer. The aim of this study was to determine the prevalence of TLR2 on T lymphocytes, B lymphocytes, monocytes, and dendritic cells in patients diagnosed with gastric cancer, with particular emphasis on the stage of the disease. Based on the obtained results, we have shown that patients with gastric cancer are characterized by a higher percentage of all tested populations of peripheral blood immune cells expressing TLR2 in relation to patients from the control group. Moreover, a detailed analysis of the collected results showed a significant link between TLR2 and the stage of the disease.https://www.mdpi.com/1422-0067/24/6/5824Toll-like receptorTLR2gastric cancerimmune system |
| spellingShingle | Marek Majewski Kamil Torres Paulina Mertowska Sebastian Mertowski Izabela Korona-Głowniak Jan Korulczyk Witold Zgodziński Ewelina Grywalska Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer? International Journal of Molecular Sciences Toll-like receptor TLR2 gastric cancer immune system |
| title | Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer? |
| title_full | Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer? |
| title_fullStr | Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer? |
| title_full_unstemmed | Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer? |
| title_short | Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer? |
| title_sort | could toll like receptor 2 serve as biomarker to detect advanced gastric cancer |
| topic | Toll-like receptor TLR2 gastric cancer immune system |
| url | https://www.mdpi.com/1422-0067/24/6/5824 |
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