Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
Deoxycholate (DA) is a natural emulsifying agent involved in the absorption of dietary lipids. Due to the facial distribution of hydrophobic-hydrophilic region, DA easily aggregates under ambient conditions, and this property hinders the practical application of DA in clinical applications. In this...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2023-10-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.230506 |
| _version_ | 1827795709577920512 |
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| author | Kyounghyoun Lee Jing Xie Hyeonjin Park Hyun Jung Jae-Min Oh |
| author_facet | Kyounghyoun Lee Jing Xie Hyeonjin Park Hyun Jung Jae-Min Oh |
| author_sort | Kyounghyoun Lee |
| collection | DOAJ |
| description | Deoxycholate (DA) is a natural emulsifying agent involved in the absorption of dietary lipids. Due to the facial distribution of hydrophobic-hydrophilic region, DA easily aggregates under ambient conditions, and this property hinders the practical application of DA in clinical applications. In this study, we found that the molecular arrangement of DA molecules could be controlled by using layered double hydroxide (LDH) under a specific reaction condition. The effect of reaction methods such as co-precipitation, ion exchange and reconstruction on the molecular arrangement of DA was investigated by X-ray diffraction, Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy and differential scanning calorimetry. It was demonstrated that the self-aggregation of DA molecules could be suppressed by the oriented arrangement of DA between the gallery space of LDH. The DA moiety was well stabilized in the LDH layers due to the electrostatic interaction between DA molecules and LDH layers. The most ordered arrangement of DA molecules was observed when DA was incorporated into LDH via a reconstruction method. The DA molecules arranged in LDH via reconstruction did not show significant exothermic or endothermic behaviour up to 400°C, showing that the DA moiety lost its intermolecular attraction in between LDH layers. |
| first_indexed | 2024-03-11T18:54:19Z |
| format | Article |
| id | doaj.art-1d76c081cef74d0595c29212c50f5937 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-03-11T18:54:19Z |
| publishDate | 2023-10-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-1d76c081cef74d0595c29212c50f59372023-10-11T07:05:29ZengThe Royal SocietyRoyal Society Open Science2054-57032023-10-01101010.1098/rsos.230506Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxideKyounghyoun Lee0Jing Xie1Hyeonjin Park2Hyun Jung3Jae-Min Oh4Department of Chemistry, Dongguk University, Seoul 04620, Republic of KoreaDepartment of Energy and Materials Engineering, Dongguk University, Seoul 04620, Republic of KoreaDepartment of Energy and Materials Engineering, Dongguk University, Seoul 04620, Republic of KoreaDepartment of Chemistry, Dongguk University, Seoul 04620, Republic of KoreaDepartment of Energy and Materials Engineering, Dongguk University, Seoul 04620, Republic of KoreaDeoxycholate (DA) is a natural emulsifying agent involved in the absorption of dietary lipids. Due to the facial distribution of hydrophobic-hydrophilic region, DA easily aggregates under ambient conditions, and this property hinders the practical application of DA in clinical applications. In this study, we found that the molecular arrangement of DA molecules could be controlled by using layered double hydroxide (LDH) under a specific reaction condition. The effect of reaction methods such as co-precipitation, ion exchange and reconstruction on the molecular arrangement of DA was investigated by X-ray diffraction, Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy and differential scanning calorimetry. It was demonstrated that the self-aggregation of DA molecules could be suppressed by the oriented arrangement of DA between the gallery space of LDH. The DA moiety was well stabilized in the LDH layers due to the electrostatic interaction between DA molecules and LDH layers. The most ordered arrangement of DA molecules was observed when DA was incorporated into LDH via a reconstruction method. The DA molecules arranged in LDH via reconstruction did not show significant exothermic or endothermic behaviour up to 400°C, showing that the DA moiety lost its intermolecular attraction in between LDH layers.https://royalsocietypublishing.org/doi/10.1098/rsos.230506deoxycholateaggregationlayered double hydroxidemolecular arrangement |
| spellingShingle | Kyounghyoun Lee Jing Xie Hyeonjin Park Hyun Jung Jae-Min Oh Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide Royal Society Open Science deoxycholate aggregation layered double hydroxide molecular arrangement |
| title | Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide |
| title_full | Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide |
| title_fullStr | Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide |
| title_full_unstemmed | Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide |
| title_short | Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide |
| title_sort | controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide |
| topic | deoxycholate aggregation layered double hydroxide molecular arrangement |
| url | https://royalsocietypublishing.org/doi/10.1098/rsos.230506 |
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