Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model

Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model

Because of rapid emergence and circulation of the SARS-CoV-2 variants, especially Omicron which shows increased transmissibility and resistant to antibodies, there is an urgent need to develop novel therapeutic drugs to treat COVID-19. In this study we developed an in vitro cellular model to explore...

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Bibliographic Details
Main Authors: Yukinori Endo, Brady T. Hickerson, Natalia A. Ilyushina, Nishant Mohan, Hanjing Peng, Kazuyo Takeda, Raymond P. Donnelly, Wen Jin Wu
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Virus Eradication
Subjects:
SARS-CoV-2
ACE2
Calu-3
Spike protein
ARP2/3 complex inhibitors
Sodium-hydrogen exchangers (NHEs) inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S205566402200245X

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