Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong Kong
With increasing off-label aesthetic indications using higher botulinum neurotoxin A (BoNT-A) doses and individuals starting treatment at a younger age, particularly in Asia, there is a greater risk of developing immunoresistance to BoNT-A. This warrants more in-depth discussions by aesthetic practit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/15/7/456 |
| _version_ | 1797587281612111872 |
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| author | Wilson W. S. Ho Lisa Chan Niamh Corduff Wang-Tak Lau Michael U. Martin Clifton Ming Tay Sandy Wang Raymond Wu |
| author_facet | Wilson W. S. Ho Lisa Chan Niamh Corduff Wang-Tak Lau Michael U. Martin Clifton Ming Tay Sandy Wang Raymond Wu |
| author_sort | Wilson W. S. Ho |
| collection | DOAJ |
| description | With increasing off-label aesthetic indications using higher botulinum neurotoxin A (BoNT-A) doses and individuals starting treatment at a younger age, particularly in Asia, there is a greater risk of developing immunoresistance to BoNT-A. This warrants more in-depth discussions by aesthetic practitioners to inform patients and guide shared decision-making. A panel comprising international experts and experienced aesthetic practitioners in Hong Kong discussed the implications and impact of immunoresistance to BoNT-A in contemporary aesthetic practice, along with practical strategies for risk management. Following discussions on a clinical case example and the results of an Asia-Pacific consumer study, the panel concurred that it is a priority to raise awareness of the possibility and long-term implications of secondary non-response due to immunoresistance to BoNT-A. Where efficacy and safety are comparable, a formulation with the lowest immunogenicity is preferred. The panel also strongly favored a thorough initial consultation to establish the patient’s treatment history, explain treatment side effects, including the causes and consequences of immunoresistance, and discuss treatment goals. Patients look to aesthetic practitioners for guidance, placing an important responsibility on practitioners to adopt risk-mitigating strategies and adequately communicate important risks to patients to support informed and prudent BoNT-A treatment decisions. |
| first_indexed | 2024-03-11T00:34:56Z |
| format | Article |
| id | doaj.art-1d7bfe7b12254036bc48fb9971ad1108 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-11T00:34:56Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-1d7bfe7b12254036bc48fb9971ad11082023-11-18T21:38:27ZengMDPI AGToxins2072-66512023-07-0115745610.3390/toxins15070456Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong KongWilson W. S. Ho0Lisa Chan1Niamh Corduff2Wang-Tak Lau3Michael U. Martin4Clifton Ming Tay5Sandy Wang6Raymond Wu7The Specialists: Lasers, Aesthetic and Plastic Surgery, Central, Hong KongEverKeen Medical Centre, Tin Hau, Hong KongCosmetic Refinement Clinic, Geelong, VIC 3220, AustraliaIndependent Researcher, Kowloon, Hong KongIndependent Researcher, 31832 Springe, GermanyMerz Asia Pacific Pte., Ltd., Singapore 138567, SingaporeIndependent Researcher, Causeway Bay, Hong KongAsia Pacific Aesthetic Academy, Kowloon, Hong KongWith increasing off-label aesthetic indications using higher botulinum neurotoxin A (BoNT-A) doses and individuals starting treatment at a younger age, particularly in Asia, there is a greater risk of developing immunoresistance to BoNT-A. This warrants more in-depth discussions by aesthetic practitioners to inform patients and guide shared decision-making. A panel comprising international experts and experienced aesthetic practitioners in Hong Kong discussed the implications and impact of immunoresistance to BoNT-A in contemporary aesthetic practice, along with practical strategies for risk management. Following discussions on a clinical case example and the results of an Asia-Pacific consumer study, the panel concurred that it is a priority to raise awareness of the possibility and long-term implications of secondary non-response due to immunoresistance to BoNT-A. Where efficacy and safety are comparable, a formulation with the lowest immunogenicity is preferred. The panel also strongly favored a thorough initial consultation to establish the patient’s treatment history, explain treatment side effects, including the causes and consequences of immunoresistance, and discuss treatment goals. Patients look to aesthetic practitioners for guidance, placing an important responsibility on practitioners to adopt risk-mitigating strategies and adequately communicate important risks to patients to support informed and prudent BoNT-A treatment decisions.https://www.mdpi.com/2072-6651/15/7/456botulinum neurotoxin Aimmunoresistancesecondary non-responseneutralizing antibodies |
| spellingShingle | Wilson W. S. Ho Lisa Chan Niamh Corduff Wang-Tak Lau Michael U. Martin Clifton Ming Tay Sandy Wang Raymond Wu Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong Kong Toxins botulinum neurotoxin A immunoresistance secondary non-response neutralizing antibodies |
| title | Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong Kong |
| title_full | Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong Kong |
| title_fullStr | Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong Kong |
| title_full_unstemmed | Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong Kong |
| title_short | Addressing the Real-World Challenges of Immunoresistance to Botulinum Neurotoxin A in Aesthetic Practice: Insights and Recommendations from a Panel Discussion in Hong Kong |
| title_sort | addressing the real world challenges of immunoresistance to botulinum neurotoxin a in aesthetic practice insights and recommendations from a panel discussion in hong kong |
| topic | botulinum neurotoxin A immunoresistance secondary non-response neutralizing antibodies |
| url | https://www.mdpi.com/2072-6651/15/7/456 |
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