Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry
Matrine alkaloid is a type of Sophora flavescens (Ku Shen) found in plants. It holds excellent applications for anticancer, antimicrobials, antibacterial, anti pests, and other applications in material chemistry such as electrochemical. Owing to its superior biological and pharmaceutical properties...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | European Journal of Medicinal Chemistry Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S277241742200070X |
| _version_ | 1827989953780383744 |
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| author | Jamal A.H. Kowah Ruobing Gao Fu Li Chenxi Guang Meiyan Jiang Xiaolin Wu Lisheng Wang Xu Liu |
| author_facet | Jamal A.H. Kowah Ruobing Gao Fu Li Chenxi Guang Meiyan Jiang Xiaolin Wu Lisheng Wang Xu Liu |
| author_sort | Jamal A.H. Kowah |
| collection | DOAJ |
| description | Matrine alkaloid is a type of Sophora flavescens (Ku Shen) found in plants. It holds excellent applications for anticancer, antimicrobials, antibacterial, anti pests, and other applications in material chemistry such as electrochemical. Owing to its superior biological and pharmaceutical properties over the past decade, pharmaceutical researchers have demonstrated that matrine can defeat the proliferation of various cancer cells, such as the proliferation of the human erythroleukemia cell line K562 and human hepatic cancer cell line SMMC-7721. This review mainly highlights the recent progress of matrine in synthesis, reaction procedures, mechanisms, and applications in medicinal, agricultural, and materials chemistry. In addition, we have also paid attention to the reactivity of matrine rings with different positions, including reactivity in N-1, C-13, C-14, (A, B, C) rings, carbonyl group at 15 positions, and amide bond at 15 and 16 positions, fused D-ring, opened A, B, and D-ring, via structural simplification, and total synthesis and design of matrine analogues from other compounds with different strategies. Particularly, the reported strategies were conducted in classical and non-classical conditions, mainly green conditions such as green solvents, catalysts, and other procedures. |
| first_indexed | 2024-04-10T00:28:24Z |
| format | Article |
| id | doaj.art-1d7d6624c40b4eb9ad1567ffe203029d |
| institution | Directory Open Access Journal |
| issn | 2772-4174 |
| language | English |
| last_indexed | 2024-04-10T00:28:24Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Medicinal Chemistry Reports |
| spelling | doaj.art-1d7d6624c40b4eb9ad1567ffe203029d2023-03-15T04:29:23ZengElsevierEuropean Journal of Medicinal Chemistry Reports2772-41742023-04-017100098Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistryJamal A.H. Kowah0Ruobing Gao1Fu Li2Chenxi Guang3Meiyan Jiang4Xiaolin Wu5Lisheng Wang6Xu Liu7School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, ChinaMedical College, Guangxi University, Nanning, 530004, ChinaMedical College, Guangxi University, Nanning, 530004, ChinaMedical College, Guangxi University, Nanning, 530004, ChinaSchool of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, ChinaSchool of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, ChinaSchool of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China; Medical College, Guangxi University, Nanning, 530004, China; Corresponding author. School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China.School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China; Medical College, Guangxi University, Nanning, 530004, China; Corresponding author. School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China.Matrine alkaloid is a type of Sophora flavescens (Ku Shen) found in plants. It holds excellent applications for anticancer, antimicrobials, antibacterial, anti pests, and other applications in material chemistry such as electrochemical. Owing to its superior biological and pharmaceutical properties over the past decade, pharmaceutical researchers have demonstrated that matrine can defeat the proliferation of various cancer cells, such as the proliferation of the human erythroleukemia cell line K562 and human hepatic cancer cell line SMMC-7721. This review mainly highlights the recent progress of matrine in synthesis, reaction procedures, mechanisms, and applications in medicinal, agricultural, and materials chemistry. In addition, we have also paid attention to the reactivity of matrine rings with different positions, including reactivity in N-1, C-13, C-14, (A, B, C) rings, carbonyl group at 15 positions, and amide bond at 15 and 16 positions, fused D-ring, opened A, B, and D-ring, via structural simplification, and total synthesis and design of matrine analogues from other compounds with different strategies. Particularly, the reported strategies were conducted in classical and non-classical conditions, mainly green conditions such as green solvents, catalysts, and other procedures.http://www.sciencedirect.com/science/article/pii/S277241742200070XMatrine derivativesSynthesisDesign and mechanismApplicationStructural modifications |
| spellingShingle | Jamal A.H. Kowah Ruobing Gao Fu Li Chenxi Guang Meiyan Jiang Xiaolin Wu Lisheng Wang Xu Liu Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry European Journal of Medicinal Chemistry Reports Matrine derivatives Synthesis Design and mechanism Application Structural modifications |
| title | Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry |
| title_full | Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry |
| title_fullStr | Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry |
| title_full_unstemmed | Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry |
| title_short | Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry |
| title_sort | matrine family derivatives synthesis reactions procedures mechanism and application in medicinal agricultural and materials chemistry |
| topic | Matrine derivatives Synthesis Design and mechanism Application Structural modifications |
| url | http://www.sciencedirect.com/science/article/pii/S277241742200070X |
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