Systems-level modeling of cancer-fibroblast interaction.

Systems-level modeling of cancer-fibroblast interaction.

Cancer cells interact with surrounding stromal fibroblasts during tumorigenesis, but the complex molecular rules that govern these interactions remain poorly understood thus hindering the development of therapeutic strategies to target cancer stroma. We have taken a mathematical approach to begin de...

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Bibliographic Details
Main Authors: Raymond C Wadlow, Ben S Wittner, S Aidan Finley, Henry Bergquist, Rabi Upadhyay, Stephen Finn, Massimo Loda, Umar Mahmood, Sridhar Ramaswamy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2731225?pdf=render

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