Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation
ATP11C is a flippase that uses ATP hydrolysis to translocate phospholipids at the plasma membrane. Here, the authors show that the activation of Ca2+-dependent protein kinase C increases ATP11C endocytosis thus downregulating phospholipid translocation.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01338-1 |
| _version_ | 1828901954165669888 |
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| author | Hiroyuki Takatsu Masahiro Takayama Tomoki Naito Naoto Takada Kazuya Tsumagari Yasushi Ishihama Kazuhisa Nakayama Hye-Won Shin |
| author_facet | Hiroyuki Takatsu Masahiro Takayama Tomoki Naito Naoto Takada Kazuya Tsumagari Yasushi Ishihama Kazuhisa Nakayama Hye-Won Shin |
| author_sort | Hiroyuki Takatsu |
| collection | DOAJ |
| description | ATP11C is a flippase that uses ATP hydrolysis to translocate phospholipids at the plasma membrane. Here, the authors show that the activation of Ca2+-dependent protein kinase C increases ATP11C endocytosis thus downregulating phospholipid translocation. |
| first_indexed | 2024-12-13T16:07:34Z |
| format | Article |
| id | doaj.art-1d7e2d5697f84925aba45325575c3bb5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:07:34Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1d7e2d5697f84925aba45325575c3bb52022-12-21T23:39:00ZengNature PortfolioNature Communications2041-17232017-11-018111510.1038/s41467-017-01338-1Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activationHiroyuki Takatsu0Masahiro Takayama1Tomoki Naito2Naoto Takada3Kazuya Tsumagari4Yasushi Ishihama5Kazuhisa Nakayama6Hye-Won Shin7Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto UniversityDepartment of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto UniversityDepartment of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto UniversityDepartment of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto UniversityMolecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto UniversityMolecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto UniversityDepartment of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto UniversityDepartment of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto UniversityATP11C is a flippase that uses ATP hydrolysis to translocate phospholipids at the plasma membrane. Here, the authors show that the activation of Ca2+-dependent protein kinase C increases ATP11C endocytosis thus downregulating phospholipid translocation.https://doi.org/10.1038/s41467-017-01338-1 |
| spellingShingle | Hiroyuki Takatsu Masahiro Takayama Tomoki Naito Naoto Takada Kazuya Tsumagari Yasushi Ishihama Kazuhisa Nakayama Hye-Won Shin Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation Nature Communications |
| title | Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation |
| title_full | Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation |
| title_fullStr | Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation |
| title_full_unstemmed | Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation |
| title_short | Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation |
| title_sort | phospholipid flippase atp11c is endocytosed and downregulated following ca2 mediated protein kinase c activation |
| url | https://doi.org/10.1038/s41467-017-01338-1 |
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