Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation
The gut microbiota produces a wide variety of metabolites, which interact with intestinal cells and contribute to host physiology. The effect of gut commensal bacteria on host protein SUMOylation, an essential ubiquitin-like modification involved in various intestinal functions, remains, however, un...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2108280 |
| _version_ | 1811214572887998464 |
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| author | Chaima Ezzine Léa Loison Nadine Montbrion Christine Bôle-Feysot Pierre Déchelotte Moïse Coëffier David Ribet |
| author_facet | Chaima Ezzine Léa Loison Nadine Montbrion Christine Bôle-Feysot Pierre Déchelotte Moïse Coëffier David Ribet |
| author_sort | Chaima Ezzine |
| collection | DOAJ |
| description | The gut microbiota produces a wide variety of metabolites, which interact with intestinal cells and contribute to host physiology. The effect of gut commensal bacteria on host protein SUMOylation, an essential ubiquitin-like modification involved in various intestinal functions, remains, however, unknown. Here, we show that short chain fatty acids (SCFAs) and branched chain fatty acids (BCFAs) produced by the gut microbiota increase protein SUMOylation in intestinal cells in a pH-dependent manner. We demonstrate that these metabolites inactivate intestinal deSUMOylases and promote the hyperSUMOylation of nuclear matrix-associated proteins. We further show that BCFAs inhibit the NF-κB pathway, decrease pro-inflammatory cytokine expression, and promote intestinal epithelial integrity. Together, our results reveal that fatty acids produced by gut commensal bacteria regulate intestinal physiology by modulating SUMOylation and illustrate a new mechanism of dampening of host inflammatory responses triggered by the gut microbiota. |
| first_indexed | 2024-04-12T06:06:57Z |
| format | Article |
| id | doaj.art-1d80c8efeb15484aac64d53dc869182e |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-12T06:06:57Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-1d80c8efeb15484aac64d53dc869182e2022-12-22T03:44:49ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2108280Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylationChaima Ezzine0Léa Loison1Nadine Montbrion2Christine Bôle-Feysot3Pierre Déchelotte4Moïse Coëffier5David Ribet6Université de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau, Rouen, FranceUniversité de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau, Rouen, FranceUniversité de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau, Rouen, FranceUniversité de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau, Rouen, FranceUniversité de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau, Rouen, FranceUniversité de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau, Rouen, FranceUniversité de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau, Rouen, FranceThe gut microbiota produces a wide variety of metabolites, which interact with intestinal cells and contribute to host physiology. The effect of gut commensal bacteria on host protein SUMOylation, an essential ubiquitin-like modification involved in various intestinal functions, remains, however, unknown. Here, we show that short chain fatty acids (SCFAs) and branched chain fatty acids (BCFAs) produced by the gut microbiota increase protein SUMOylation in intestinal cells in a pH-dependent manner. We demonstrate that these metabolites inactivate intestinal deSUMOylases and promote the hyperSUMOylation of nuclear matrix-associated proteins. We further show that BCFAs inhibit the NF-κB pathway, decrease pro-inflammatory cytokine expression, and promote intestinal epithelial integrity. Together, our results reveal that fatty acids produced by gut commensal bacteria regulate intestinal physiology by modulating SUMOylation and illustrate a new mechanism of dampening of host inflammatory responses triggered by the gut microbiota.https://www.tandfonline.com/doi/10.1080/19490976.2022.2108280Gut microbiotaMicrobiotaShort Chain Fatty Acids (SCFAs)Branched Chain Fatty Acids (BCFAs)SUMOylationUbiquitin-like proteins |
| spellingShingle | Chaima Ezzine Léa Loison Nadine Montbrion Christine Bôle-Feysot Pierre Déchelotte Moïse Coëffier David Ribet Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation Gut Microbes Gut microbiota Microbiota Short Chain Fatty Acids (SCFAs) Branched Chain Fatty Acids (BCFAs) SUMOylation Ubiquitin-like proteins |
| title | Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation |
| title_full | Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation |
| title_fullStr | Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation |
| title_full_unstemmed | Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation |
| title_short | Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation |
| title_sort | fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal sumoylation |
| topic | Gut microbiota Microbiota Short Chain Fatty Acids (SCFAs) Branched Chain Fatty Acids (BCFAs) SUMOylation Ubiquitin-like proteins |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2108280 |
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