Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT
ABSTRACT Primary progressive aphasia is a clinical syndrome caused by neurodegeneration of areas and neural networks involved in language, usually in the left hemisphere. The term “crossed aphasia” denotes an acquired language dysfunction caused by a lesion in the ipsilateral hemisphere to the domin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
2023-12-01
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| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642023000100603&lng=en&tlng=en |
| _version_ | 1797394254943748096 |
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| author | Paulo Roberto de Brito-Marques Janaina Mariana de Araujo Miranda Brito-Marques |
| author_facet | Paulo Roberto de Brito-Marques Janaina Mariana de Araujo Miranda Brito-Marques |
| author_sort | Paulo Roberto de Brito-Marques |
| collection | DOAJ |
| description | ABSTRACT Primary progressive aphasia is a clinical syndrome caused by neurodegeneration of areas and neural networks involved in language, usually in the left hemisphere. The term “crossed aphasia” denotes an acquired language dysfunction caused by a lesion in the ipsilateral hemisphere to the dominant hand. Objective: To describe a case of crossed aphasia in a 60-year-old left-handed patient with a non-fluent variant of primary progressive aphasia diagnosis (age of onset=52), evidenced by a left asymmetry on brain SPECT scan. Methods: Clinical and family history, the Edinburgh Handedness Inventory, Measurement of Functional Activities in Older Adults in the Community, the “Mini-Mental State Examination”, the Trail Making Test, the Tower of London, and the Neuropsychological assessment for dementia, and neuroimaging studies were carried out. Results: Neuropsychological assessment showed severe cognitive impairment, especially regarding language. The magnetic resonance imaging showed important signs of cortico-subcortical atrophy, with predominance in the frontal and temporal lobes. The single-photon emission computed tomography scan showed moderate to severe hypoperfusion in the left cerebral hemisphere, including the hippocampus. Conclusion: We described a clinical case of crossed aphasia in a left-handed woman with a non-fluent variant of primary progressive aphasia with asymmetry on brain SPECT, mainly on the left, followed up for seven years. |
| first_indexed | 2024-03-09T00:16:56Z |
| format | Article |
| id | doaj.art-1d8311d6024e4161acd8838f489bcec2 |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-03-09T00:16:56Z |
| publishDate | 2023-12-01 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-1d8311d6024e4161acd8838f489bcec22023-12-12T07:50:54ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57642023-12-011710.1590/1980-5764-dn-2022-0095Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECTPaulo Roberto de Brito-Marqueshttps://orcid.org/0000-0002-5977-1294Janaina Mariana de Araujo Miranda Brito-Marqueshttps://orcid.org/0000-0001-7886-0789ABSTRACT Primary progressive aphasia is a clinical syndrome caused by neurodegeneration of areas and neural networks involved in language, usually in the left hemisphere. The term “crossed aphasia” denotes an acquired language dysfunction caused by a lesion in the ipsilateral hemisphere to the dominant hand. Objective: To describe a case of crossed aphasia in a 60-year-old left-handed patient with a non-fluent variant of primary progressive aphasia diagnosis (age of onset=52), evidenced by a left asymmetry on brain SPECT scan. Methods: Clinical and family history, the Edinburgh Handedness Inventory, Measurement of Functional Activities in Older Adults in the Community, the “Mini-Mental State Examination”, the Trail Making Test, the Tower of London, and the Neuropsychological assessment for dementia, and neuroimaging studies were carried out. Results: Neuropsychological assessment showed severe cognitive impairment, especially regarding language. The magnetic resonance imaging showed important signs of cortico-subcortical atrophy, with predominance in the frontal and temporal lobes. The single-photon emission computed tomography scan showed moderate to severe hypoperfusion in the left cerebral hemisphere, including the hippocampus. Conclusion: We described a clinical case of crossed aphasia in a left-handed woman with a non-fluent variant of primary progressive aphasia with asymmetry on brain SPECT, mainly on the left, followed up for seven years.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642023000100603&lng=en&tlng=enTomography, Emission-Computed, Single-PhotonNeurodegenerative DiseasesDominance, CerebralDementiaAphasia, Primary Progressive |
| spellingShingle | Paulo Roberto de Brito-Marques Janaina Mariana de Araujo Miranda Brito-Marques Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT Dementia & Neuropsychologia Tomography, Emission-Computed, Single-Photon Neurodegenerative Diseases Dominance, Cerebral Dementia Aphasia, Primary Progressive |
| title | Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT |
| title_full | Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT |
| title_fullStr | Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT |
| title_full_unstemmed | Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT |
| title_short | Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT |
| title_sort | crossed aphasia in a left handed patient with non fluent variant of primary progressive aphasia with left asymmetric brain spect |
| topic | Tomography, Emission-Computed, Single-Photon Neurodegenerative Diseases Dominance, Cerebral Dementia Aphasia, Primary Progressive |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642023000100603&lng=en&tlng=en |
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