Central Hyperthermia Treated with Baclofen in a Patient with Epidural Hematoma
Central hyperthermia is characterized by a rapid-onset elevated temperature, marked temperature fluctuation, and poor response to antipyretics and antibiotics. It is caused by impairment of the central thermoregulatory pathways and is associated with high morbidity and mortality. We report on a case...
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| Format: | Article |
| Language: | English |
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NESON
2016-12-01
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| Series: | Nepal Journal of Neuroscience |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/NJN/article/view/20488 |
| _version_ | 1819065183519113216 |
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| author | Manoj Bohara Prasanna K Bohara Lalit Chaudhary Basant Pant |
| author_facet | Manoj Bohara Prasanna K Bohara Lalit Chaudhary Basant Pant |
| author_sort | Manoj Bohara |
| collection | DOAJ |
| description | Central hyperthermia is characterized by a rapid-onset elevated temperature, marked temperature fluctuation, and poor response to antipyretics and antibiotics. It is caused by impairment of the central thermoregulatory pathways and is associated with high morbidity and mortality. We report on a case of 31-year old male who sustained fall injury with massive epidural hematoma and a high-grade fever of 40°C on presentation. Following cranio to my and evacuation of hematoma, antipyretics and antibiotics were used for high-grade fever but were not effective. Baclofen was orally administered which effectively controlled the fever. Here, we also discuss the possible central mechanisms for this effect of baclofen and show that baclofen may be an effective treatment in central hyperthermia. |
| first_indexed | 2024-12-21T15:42:25Z |
| format | Article |
| id | doaj.art-1d83d19c2313491980710539041d2a38 |
| institution | Directory Open Access Journal |
| issn | 1813-1948 1813-1956 |
| language | English |
| last_indexed | 2024-12-21T15:42:25Z |
| publishDate | 2016-12-01 |
| publisher | NESON |
| record_format | Article |
| series | Nepal Journal of Neuroscience |
| spelling | doaj.art-1d83d19c2313491980710539041d2a382022-12-21T18:58:27ZengNESONNepal Journal of Neuroscience1813-19481813-19562016-12-01132102104https://doi.org/10.3126/njn.v13i2.20488Central Hyperthermia Treated with Baclofen in a Patient with Epidural HematomaManoj Bohara 0Prasanna K Bohara 1Lalit Chaudhary 2Basant Pant 3Department of Neurosurgery Nepalgunj Medical College Teaching Hospital NepalgunjDepartment of Neurosurgery Nepalgunj Medical College Teaching Hospital NepalgunjDepartment of Neurosurgery Nepalgunj Medical College Teaching Hospital NepalgunjDepartment of Neurosurgery Annapurna Neurological Institute and Allied Sciences Hospital Maitighar, KathmanduCentral hyperthermia is characterized by a rapid-onset elevated temperature, marked temperature fluctuation, and poor response to antipyretics and antibiotics. It is caused by impairment of the central thermoregulatory pathways and is associated with high morbidity and mortality. We report on a case of 31-year old male who sustained fall injury with massive epidural hematoma and a high-grade fever of 40°C on presentation. Following cranio to my and evacuation of hematoma, antipyretics and antibiotics were used for high-grade fever but were not effective. Baclofen was orally administered which effectively controlled the fever. Here, we also discuss the possible central mechanisms for this effect of baclofen and show that baclofen may be an effective treatment in central hyperthermia.https://www.nepjol.info/index.php/NJN/article/view/20488baclofenbrain injurycentral hyperthermiafever |
| spellingShingle | Manoj Bohara Prasanna K Bohara Lalit Chaudhary Basant Pant Central Hyperthermia Treated with Baclofen in a Patient with Epidural Hematoma Nepal Journal of Neuroscience baclofen brain injury central hyperthermia fever |
| title | Central Hyperthermia Treated with Baclofen in a Patient with Epidural Hematoma |
| title_full | Central Hyperthermia Treated with Baclofen in a Patient with Epidural Hematoma |
| title_fullStr | Central Hyperthermia Treated with Baclofen in a Patient with Epidural Hematoma |
| title_full_unstemmed | Central Hyperthermia Treated with Baclofen in a Patient with Epidural Hematoma |
| title_short | Central Hyperthermia Treated with Baclofen in a Patient with Epidural Hematoma |
| title_sort | central hyperthermia treated with baclofen in a patient with epidural hematoma |
| topic | baclofen brain injury central hyperthermia fever |
| url | https://www.nepjol.info/index.php/NJN/article/view/20488 |
| work_keys_str_mv | AT manojbohara centralhyperthermiatreatedwithbaclofeninapatientwithepiduralhematoma AT prasannakbohara centralhyperthermiatreatedwithbaclofeninapatientwithepiduralhematoma AT lalitchaudhary centralhyperthermiatreatedwithbaclofeninapatientwithepiduralhematoma AT basantpant centralhyperthermiatreatedwithbaclofeninapatientwithepiduralhematoma |