PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTS
Aim. The aim of this study was to define the role of preformed anti-HLA antibodies (anti-HLA) in antibody-mediated rejection (AMR) and cardiac allograft vasculopathy (CAV) after heart transplantation. Materials and Methods. 140 heart transplant recipients were followed after heart transplantation pe...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2014-05-01
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| Series: | Вестник трансплантологии и искусственных органов |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/76 |
| _version_ | 1826546467184050176 |
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| author | O. P. Shevchenko T. A. Khalilulin G. A. Olefirenko R. M. Kurabekova N. V. Apanasenko A. O. Shevchenko B. L. Mironkov I. M. Ilyinsky A. G. Kupriyanova A. J. Kormer |
| author_facet | O. P. Shevchenko T. A. Khalilulin G. A. Olefirenko R. M. Kurabekova N. V. Apanasenko A. O. Shevchenko B. L. Mironkov I. M. Ilyinsky A. G. Kupriyanova A. J. Kormer |
| author_sort | O. P. Shevchenko |
| collection | DOAJ |
| description | Aim. The aim of this study was to define the role of preformed anti-HLA antibodies (anti-HLA) in antibody-mediated rejection (AMR) and cardiac allograft vasculopathy (CAV) after heart transplantation. Materials and Methods. 140 heart transplant recipients were followed after heart transplantation performed for 106 dilated and 34 – ischemic cardiomyopathy. Anti-HLA was determined before transplantation by ELISA. Results. Recipients were divided into 2 groups: anti-HLA positive (n = 45, 32,1%) and anti-HLA negative (n = 95, 67,9%). The incidence of AMR in anti-HLA positive group was 12 (26,67%) and 11 (11,58%) in anti-HLA negative group. Risk of AMR was significantly higher in anti-HLA positive recipients (RR 2,3: 95% CI 1,02–4,81, р = 0,03). During first three years after transplantation CAV was diagnosed in 9 (20%) of anti-HLA positive recipients and in 7 (6,8%) of patients without anti-HLA. (RR 2,7: 95% CI 1,08–6,82, р = 0,03). Survival in freedom from CAV in anti-HLA negative recipients was much higher than in anti-HLA positive recipients (0,89 ± 0,07, 0,72 ± 0,06, resp. (p = 0,02)).Conclusions. The presence of preformed anti-HLA antibodies in candidates for heart transplantation increase the risk of AMR and CAV post transplantation in 2,3 and 2,7 times, respectively. |
| first_indexed | 2024-04-10T00:54:52Z |
| format | Article |
| id | doaj.art-1d84023c03884ca4ad1a10d08f56cfc7 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2025-03-14T05:34:13Z |
| publishDate | 2014-05-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj.art-1d84023c03884ca4ad1a10d08f56cfc72025-03-05T14:11:44ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912014-05-01154162310.15825/1995-1191-2013-4-16-2319PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTSO. P. Shevchenko0T. A. Khalilulin1G. A. Olefirenko2R. M. Kurabekova3N. V. Apanasenko4A. O. Shevchenko5B. L. Mironkov6I. M. Ilyinsky7A. G. Kupriyanova8A. J. Kormer9Department of regulatory mechanisms in transplantology (Head – prof. O.P. Shevchenko) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian FederationDepartment of cardiac surgery, heart and lung transplantation (Head – prof. R.Sh. Saitgareev) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation Chair of transplantology and artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian FederationDepartment of regulatory mechanisms in transplantology (Head – prof. O.P. Shevchenko) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian FederationDepartment of regulatory mechanisms in transplantology (Head – prof. O.P. Shevchenko) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian FederationDepartment of regulatory mechanisms in transplantology (Head – prof. O.P. Shevchenko) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian FederationDepartment of coordination and monitoring of research programs of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation Pirogov Russian National Research Medical University. Faculty of advanced medical studies (Rector – prof. A.G. Kamkin), Moscow, Russian FederationDepartment of cardiac surgery, heart and lung transplantation (Head – prof. R.Sh. Saitgareev) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian FederationChair of transplantology and artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation Department of clinical pathology (Head – prof. I.M. Ilyinsky) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian FederationChair of transplantology and artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation Laboratory of immunohistochemistry (Head – cand. of med. sci. A.G. Kupriyanova, department of clinical pathology (Head – prof. I.M. Ilyinsky) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian FederationDepartment of cardiac surgery, heart and lung transplantation (Head – prof. R.Sh. Saitgareev) of Academician V.I. Shumakov federal research center of transplantology and artificial organs, Ministry of Health of Russian Federation (Head – academician of RAMSci, prof. S.V. Gautier), Moscow, Russian FederationAim. The aim of this study was to define the role of preformed anti-HLA antibodies (anti-HLA) in antibody-mediated rejection (AMR) and cardiac allograft vasculopathy (CAV) after heart transplantation. Materials and Methods. 140 heart transplant recipients were followed after heart transplantation performed for 106 dilated and 34 – ischemic cardiomyopathy. Anti-HLA was determined before transplantation by ELISA. Results. Recipients were divided into 2 groups: anti-HLA positive (n = 45, 32,1%) and anti-HLA negative (n = 95, 67,9%). The incidence of AMR in anti-HLA positive group was 12 (26,67%) and 11 (11,58%) in anti-HLA negative group. Risk of AMR was significantly higher in anti-HLA positive recipients (RR 2,3: 95% CI 1,02–4,81, р = 0,03). During first three years after transplantation CAV was diagnosed in 9 (20%) of anti-HLA positive recipients and in 7 (6,8%) of patients without anti-HLA. (RR 2,7: 95% CI 1,08–6,82, р = 0,03). Survival in freedom from CAV in anti-HLA negative recipients was much higher than in anti-HLA positive recipients (0,89 ± 0,07, 0,72 ± 0,06, resp. (p = 0,02)).Conclusions. The presence of preformed anti-HLA antibodies in candidates for heart transplantation increase the risk of AMR and CAV post transplantation in 2,3 and 2,7 times, respectively.https://journal.transpl.ru/vtio/article/view/76heart transplantation, anti-hla antibodies, antibody-mediated rejection, cardiac allograft vasculopathy. |
| spellingShingle | O. P. Shevchenko T. A. Khalilulin G. A. Olefirenko R. M. Kurabekova N. V. Apanasenko A. O. Shevchenko B. L. Mironkov I. M. Ilyinsky A. G. Kupriyanova A. J. Kormer PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTS Вестник трансплантологии и искусственных органов heart transplantation, anti-hla antibodies, antibody-mediated rejection, cardiac allograft vasculopathy. |
| title | PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTS |
| title_full | PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTS |
| title_fullStr | PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTS |
| title_full_unstemmed | PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTS |
| title_short | PREDICTIVE SIGNIFICANCE OF ANTI-HLA AUTOANTIBODIES IN HEART TRANSPLANT RECIPIENTS |
| title_sort | predictive significance of anti hla autoantibodies in heart transplant recipients |
| topic | heart transplantation, anti-hla antibodies, antibody-mediated rejection, cardiac allograft vasculopathy. |
| url | https://journal.transpl.ru/vtio/article/view/76 |
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