Personalization of injection protocols to the individual patient's blood volume and automated tube voltage selection (ATVS) in coronary CTA.
PURPOSE:The aim was to assess personalised contrast media (CM) protocols-based on patient's blood volume (BV) and automated tube voltage selection (ATVS)-in coronary computed tomography angiography (CCTA). METHODS:A total of 114 consecutive patients received an ECG-triggered or ECG-gated helica...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6157854?pdf=render |
| _version_ | 1818310163824640000 |
|---|---|
| author | Nienke G Eijsvoogel Babs M F Hendriks Jef L Willigers Bibi Martens Luc F Carati Barbora Horehledova Bastiaan L J H Kietselaer Harry J G M Crijns Joachim E Wildberger Marco Das |
| author_facet | Nienke G Eijsvoogel Babs M F Hendriks Jef L Willigers Bibi Martens Luc F Carati Barbora Horehledova Bastiaan L J H Kietselaer Harry J G M Crijns Joachim E Wildberger Marco Das |
| author_sort | Nienke G Eijsvoogel |
| collection | DOAJ |
| description | PURPOSE:The aim was to assess personalised contrast media (CM) protocols-based on patient's blood volume (BV) and automated tube voltage selection (ATVS)-in coronary computed tomography angiography (CCTA). METHODS:A total of 114 consecutive patients received an ECG-triggered or ECG-gated helical scan on a 3rd-generation dual-source CT with 70-120kV (ATVS) and 330mAsqual.ref. CM was adapted to BV, scan time (s) and kV. Image quality (IQ) was assessed in a 17-segment coronary model using attenuation values (HU), contrast-to-noise (CNR), signal-to-noise ratio (SNR) (objective IQ) and a Likert scale (subjective IQ: 1 = poor/2 = sufficient/3 = good/4 = excellent). ig. RESULTS:Patient distribution was: n = 60 for 70kV, n = 37 80kV and n = 17 90kV. Mean BV was 5.4±0.6L for men and 4.1±0.6L for women. Mean CM volume (300 mg I/mL) and flow rate were: 30.9±6.4mL and 3.3±0.5mL/s (70kV); 40.8±7.1mL and 4.5±0.6mL/s (80kV); 53.6±8.6mL and 5.7±0.6mL/s (90kV). Overall mean HU was >300HU in 98.2% (112/114) of patients. Overall mean attenuation was below 300HU in two scans (70kV) due to late scan timing. Of 1.661 segments, 95.4% was assessable. Mean CNR was 14±4(70kV), 13±3(80kV) and 14±4(90kV); mean SNR was 10±2(both 70kV+80kV) and 9±2(90kV). Objective IQ was comparable between kV settings, protocols and sex. Subjective IQ was diagnostic in all scans and excellent-sufficient in 95.4% of segments. CONCLUSIONS:Personalisation of CCTA CM injection protocols to BV and ATVS is a promising technique to tailor CM administration to the individual patient, while maintaining diagnostic IQ. |
| first_indexed | 2024-12-13T07:41:42Z |
| format | Article |
| id | doaj.art-1d84b57395274fb3a4ab14be37bdf406 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T07:41:42Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1d84b57395274fb3a4ab14be37bdf4062022-12-21T23:54:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020368210.1371/journal.pone.0203682Personalization of injection protocols to the individual patient's blood volume and automated tube voltage selection (ATVS) in coronary CTA.Nienke G EijsvoogelBabs M F HendriksJef L WilligersBibi MartensLuc F CaratiBarbora HorehledovaBastiaan L J H KietselaerHarry J G M CrijnsJoachim E WildbergerMarco DasPURPOSE:The aim was to assess personalised contrast media (CM) protocols-based on patient's blood volume (BV) and automated tube voltage selection (ATVS)-in coronary computed tomography angiography (CCTA). METHODS:A total of 114 consecutive patients received an ECG-triggered or ECG-gated helical scan on a 3rd-generation dual-source CT with 70-120kV (ATVS) and 330mAsqual.ref. CM was adapted to BV, scan time (s) and kV. Image quality (IQ) was assessed in a 17-segment coronary model using attenuation values (HU), contrast-to-noise (CNR), signal-to-noise ratio (SNR) (objective IQ) and a Likert scale (subjective IQ: 1 = poor/2 = sufficient/3 = good/4 = excellent). ig. RESULTS:Patient distribution was: n = 60 for 70kV, n = 37 80kV and n = 17 90kV. Mean BV was 5.4±0.6L for men and 4.1±0.6L for women. Mean CM volume (300 mg I/mL) and flow rate were: 30.9±6.4mL and 3.3±0.5mL/s (70kV); 40.8±7.1mL and 4.5±0.6mL/s (80kV); 53.6±8.6mL and 5.7±0.6mL/s (90kV). Overall mean HU was >300HU in 98.2% (112/114) of patients. Overall mean attenuation was below 300HU in two scans (70kV) due to late scan timing. Of 1.661 segments, 95.4% was assessable. Mean CNR was 14±4(70kV), 13±3(80kV) and 14±4(90kV); mean SNR was 10±2(both 70kV+80kV) and 9±2(90kV). Objective IQ was comparable between kV settings, protocols and sex. Subjective IQ was diagnostic in all scans and excellent-sufficient in 95.4% of segments. CONCLUSIONS:Personalisation of CCTA CM injection protocols to BV and ATVS is a promising technique to tailor CM administration to the individual patient, while maintaining diagnostic IQ.http://europepmc.org/articles/PMC6157854?pdf=render |
| spellingShingle | Nienke G Eijsvoogel Babs M F Hendriks Jef L Willigers Bibi Martens Luc F Carati Barbora Horehledova Bastiaan L J H Kietselaer Harry J G M Crijns Joachim E Wildberger Marco Das Personalization of injection protocols to the individual patient's blood volume and automated tube voltage selection (ATVS) in coronary CTA. PLoS ONE |
| title | Personalization of injection protocols to the individual patient's blood volume and automated tube voltage selection (ATVS) in coronary CTA. |
| title_full | Personalization of injection protocols to the individual patient's blood volume and automated tube voltage selection (ATVS) in coronary CTA. |
| title_fullStr | Personalization of injection protocols to the individual patient's blood volume and automated tube voltage selection (ATVS) in coronary CTA. |
| title_full_unstemmed | Personalization of injection protocols to the individual patient's blood volume and automated tube voltage selection (ATVS) in coronary CTA. |
| title_short | Personalization of injection protocols to the individual patient's blood volume and automated tube voltage selection (ATVS) in coronary CTA. |
| title_sort | personalization of injection protocols to the individual patient s blood volume and automated tube voltage selection atvs in coronary cta |
| url | http://europepmc.org/articles/PMC6157854?pdf=render |
| work_keys_str_mv | AT nienkegeijsvoogel personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT babsmfhendriks personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT jeflwilligers personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT bibimartens personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT lucfcarati personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT barborahorehledova personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT bastiaanljhkietselaer personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT harryjgmcrijns personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT joachimewildberger personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta AT marcodas personalizationofinjectionprotocolstotheindividualpatientsbloodvolumeandautomatedtubevoltageselectionatvsincoronarycta |