Effect of Oral Morphine Consumption in Female Rats on Development of Brain Cavities, Central Canal and Choroid Plexus of Their Embryos
Objective: Previous studies have shown that morphine consumption during pregnancymay delay embryo development or cause abnormal nervous system function. The presentstudy focused on the effects of maternal morphine consumption on brain cavities andcentral canal development in Wistar rats.Materials an...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2011-01-01
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| Series: | Cell Journal |
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| Online Access: | http://celljournal.org/library/upload/article/af_4233632Kazemi.pdf |
| _version_ | 1819040158132994048 |
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| author | Masoomeh Kazemi Hedayat Sahraei Mahnaz Azarnia Leila Dehghani Hossein Bahadoran |
| author_facet | Masoomeh Kazemi Hedayat Sahraei Mahnaz Azarnia Leila Dehghani Hossein Bahadoran |
| author_sort | Masoomeh Kazemi |
| collection | DOAJ |
| description | Objective: Previous studies have shown that morphine consumption during pregnancymay delay embryo development or cause abnormal nervous system function. The presentstudy focused on the effects of maternal morphine consumption on brain cavities andcentral canal development in Wistar rats.Materials and Methods: In this study Wistar rats (average weight: 170-200 g) were used.The experimental group, after pregnancy, received 0.05 mg/ml of morphine by tap waterwhile the control group received water. On the 17th day of pregnancy, the pregnant animalswere anesthetized by chloroform and embryos were surgically removed. The sampleswere fixed in 10% formalin for four weeks. Then, tissues were processed and sectioned.Sections were stained with hematoxylin and eosin (H&E) and examined for ventricle, centralcanal and choroid plexus development by light microscopy and MOTIC software.Results: Severe reductions of the third and lateral ventricles were observed in the experimentalgroup. In addition, an increase in the choroid plexus (CP) area in the experimentalgroup with regards to the control group was identified.Conclusion: The study showed that oral morphine consumption lead to reduction in thethird and lateral brain cavities and an increase in the CP area. This defect may cause behavioralchanges observed in the F1 generation from addicted pregnant animals. |
| first_indexed | 2024-12-21T09:04:39Z |
| format | Article |
| id | doaj.art-1d85ba831b374d128fec8e7c59513760 |
| institution | Directory Open Access Journal |
| issn | 2228-5806 2228-5814 |
| language | English |
| last_indexed | 2024-12-21T09:04:39Z |
| publishDate | 2011-01-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | Cell Journal |
| spelling | doaj.art-1d85ba831b374d128fec8e7c595137602022-12-21T19:09:23ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142011-01-01124489494Effect of Oral Morphine Consumption in Female Rats on Development of Brain Cavities, Central Canal and Choroid Plexus of Their EmbryosMasoomeh KazemiHedayat SahraeiMahnaz AzarniaLeila DehghaniHossein BahadoranObjective: Previous studies have shown that morphine consumption during pregnancymay delay embryo development or cause abnormal nervous system function. The presentstudy focused on the effects of maternal morphine consumption on brain cavities andcentral canal development in Wistar rats.Materials and Methods: In this study Wistar rats (average weight: 170-200 g) were used.The experimental group, after pregnancy, received 0.05 mg/ml of morphine by tap waterwhile the control group received water. On the 17th day of pregnancy, the pregnant animalswere anesthetized by chloroform and embryos were surgically removed. The sampleswere fixed in 10% formalin for four weeks. Then, tissues were processed and sectioned.Sections were stained with hematoxylin and eosin (H&E) and examined for ventricle, centralcanal and choroid plexus development by light microscopy and MOTIC software.Results: Severe reductions of the third and lateral ventricles were observed in the experimentalgroup. In addition, an increase in the choroid plexus (CP) area in the experimentalgroup with regards to the control group was identified.Conclusion: The study showed that oral morphine consumption lead to reduction in thethird and lateral brain cavities and an increase in the CP area. This defect may cause behavioralchanges observed in the F1 generation from addicted pregnant animals.http://celljournal.org/library/upload/article/af_4233632Kazemi.pdfBrainCavityChoroid PlexusMorphineWistar Rats |
| spellingShingle | Masoomeh Kazemi Hedayat Sahraei Mahnaz Azarnia Leila Dehghani Hossein Bahadoran Effect of Oral Morphine Consumption in Female Rats on Development of Brain Cavities, Central Canal and Choroid Plexus of Their Embryos Cell Journal Brain Cavity Choroid Plexus Morphine Wistar Rats |
| title | Effect of Oral Morphine Consumption in Female Rats on Development of Brain Cavities, Central Canal and Choroid Plexus of Their Embryos |
| title_full | Effect of Oral Morphine Consumption in Female Rats on Development of Brain Cavities, Central Canal and Choroid Plexus of Their Embryos |
| title_fullStr | Effect of Oral Morphine Consumption in Female Rats on Development of Brain Cavities, Central Canal and Choroid Plexus of Their Embryos |
| title_full_unstemmed | Effect of Oral Morphine Consumption in Female Rats on Development of Brain Cavities, Central Canal and Choroid Plexus of Their Embryos |
| title_short | Effect of Oral Morphine Consumption in Female Rats on Development of Brain Cavities, Central Canal and Choroid Plexus of Their Embryos |
| title_sort | effect of oral morphine consumption in female rats on development of brain cavities central canal and choroid plexus of their embryos |
| topic | Brain Cavity Choroid Plexus Morphine Wistar Rats |
| url | http://celljournal.org/library/upload/article/af_4233632Kazemi.pdf |
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