TG/HDL-C Ratio and ba-PWV in Patients with Essential Hypertension
BackgroundDyslipidemia is a major risk factor for cardiovascular disease. Triglyceride /high-density lipoprotein cholesterol (TG/HDL-C) ratio has been proved to be more effective in predicting cardiovascular events than a blood lipid index or low-density lipoprotein cholesterol (LDL-C) /HDL-C ratio....
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2022-01-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/1640772960809-1157370945.pdf |
| _version_ | 1797217285282201600 |
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| author | ZENG Rong, ZHENG Keyang, YAN Jiafu, WANG Zuoguang, CHENG Wenli |
| author_facet | ZENG Rong, ZHENG Keyang, YAN Jiafu, WANG Zuoguang, CHENG Wenli |
| author_sort | ZENG Rong, ZHENG Keyang, YAN Jiafu, WANG Zuoguang, CHENG Wenli |
| collection | DOAJ |
| description | BackgroundDyslipidemia is a major risk factor for cardiovascular disease. Triglyceride /high-density lipoprotein cholesterol (TG/HDL-C) ratio has been proved to be more effective in predicting cardiovascular events than a blood lipid index or low-density lipoprotein cholesterol (LDL-C) /HDL-C ratio. There are few clinical studies about TG/HDL-C ratio assessing arterial stiffness in hypertensive populations. Moreover, studies on the characteristics of ambulatory blood pressure parameters by TG/HDL-C ratio are also rare.ObjectiveTo explore the association of fasting TG/HDL-C ratio with brachial-ankle pulse wave velocity (ba-PWV) in essential hypertensive patients based on analyzing these patients' clinical features, ambulatory blood pressure and ba-PWV.MethodsA total of 439 essential hypertension patients (aged 18-80 years) were recruited from Hypertension Department, Beijing Anzhen Hospital, Capital Medical University from August 2014 to December 2015. Data were collected, including sex, age and medical history (diabetes history, hyperlipidemia history, smoking status, drinking status) , height, weight, BMI, serum creatinine, total cholesterol, TG, LDL-C, HDL-C, serum uric acid, fasting blood glucose, calculated TG/HDL-C ratio, 24 h ambulatory blood pressure parameters〔mean systolic blood pressure (SBP) , diastolic blood pressure (DBP) and heart rate in 24 h, in the daytime and at the nighttime, prevalence of nocturnal fall in SBP and DBP, and dipper blood pressure pattern〕 during hospitalization, and mean heart rate. Arterial stiffness was assessed by ba-PWV. The above-mentioned indicators were compared between lower (n=219) and higher quantile groups (n=220) divided by TG/HDL-C ratio. The influencing factors of ba-PWV were investigated by multiple linear regression analysis.Results(1) Higher quantile group had higher male proportion, higher prevalence of hyperlipidemia and smokers, higher mean BMI, serum creatinine, total cholesterol, TG, serum uric acid, and fasting blood glucose, as well as lower men age, and HDL-C than lower quantile group (P<0.05) . (2) Higher quantile group had higher mean 24-hour SBP and DBP, daytime SBP and DBP, nighttime SBP and DBP, nighttime heart rate and ba-PWV, and lower prevalence of nocturnal fall in SBP and DBP, and dippers than lower quantile group (P<0.05) . (3) Multiple linear regression analysis showed that, age〔β=12.35, 95%CI (10.307, 14.401) 〕, fasting blood glucose〔β=20.69, 95%CI (1.532, 39.854) 〕, TG/HDL-C ratio〔β=20.99, 95%CI (6.176, 35.810) 〕 and 24 hour mean SBP〔β=7.57, 95%CI (5.656, 9.493) 〕 were associated with ba-PWV (P<0.05) .ConclusionIn essential hypertension patients, elevated 24-hour SBP and DBP were found in those with higher TG/HDL-C ratio, and TG/HDL-C ratio may be independently associated with ba-PWV. Monitoring TG/HDL-C ratio helps early detection of arteriosclerosis and elevated blood pressure, promoting comprehensive management of cardiovascular risk factors. |
| first_indexed | 2024-04-24T11:59:25Z |
| format | Article |
| id | doaj.art-1d85c00965c248ecafd9565f2926893f |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:59:25Z |
| publishDate | 2022-01-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-1d85c00965c248ecafd9565f2926893f2024-04-09T02:47:57ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-01-01250215315810.12114/j.issn.1007-9572.2021.01.223TG/HDL-C Ratio and ba-PWV in Patients with Essential HypertensionZENG Rong, ZHENG Keyang, YAN Jiafu, WANG Zuoguang, CHENG Wenli0 1.Department of Hypertension，Beijing Anzhen Hospital，Capital Medical University，Beijing 100029，China 2.Department of Hypertension Research，Beijing Anzhen Hospital，Capital Medical University/Beijing Institute of Heart Lung and Blood Vessel Diseases，Beijing 100029，China *Corresponding author：CHENG Wenli，Professor，Chief physician；E-mail：chengwenli2000@163.com BackgroundDyslipidemia is a major risk factor for cardiovascular disease. Triglyceride /high-density lipoprotein cholesterol (TG/HDL-C) ratio has been proved to be more effective in predicting cardiovascular events than a blood lipid index or low-density lipoprotein cholesterol (LDL-C) /HDL-C ratio. There are few clinical studies about TG/HDL-C ratio assessing arterial stiffness in hypertensive populations. Moreover, studies on the characteristics of ambulatory blood pressure parameters by TG/HDL-C ratio are also rare.ObjectiveTo explore the association of fasting TG/HDL-C ratio with brachial-ankle pulse wave velocity (ba-PWV) in essential hypertensive patients based on analyzing these patients' clinical features, ambulatory blood pressure and ba-PWV.MethodsA total of 439 essential hypertension patients (aged 18-80 years) were recruited from Hypertension Department, Beijing Anzhen Hospital, Capital Medical University from August 2014 to December 2015. Data were collected, including sex, age and medical history (diabetes history, hyperlipidemia history, smoking status, drinking status) , height, weight, BMI, serum creatinine, total cholesterol, TG, LDL-C, HDL-C, serum uric acid, fasting blood glucose, calculated TG/HDL-C ratio, 24 h ambulatory blood pressure parameters〔mean systolic blood pressure (SBP) , diastolic blood pressure (DBP) and heart rate in 24 h, in the daytime and at the nighttime, prevalence of nocturnal fall in SBP and DBP, and dipper blood pressure pattern〕 during hospitalization, and mean heart rate. Arterial stiffness was assessed by ba-PWV. The above-mentioned indicators were compared between lower (n=219) and higher quantile groups (n=220) divided by TG/HDL-C ratio. The influencing factors of ba-PWV were investigated by multiple linear regression analysis.Results(1) Higher quantile group had higher male proportion, higher prevalence of hyperlipidemia and smokers, higher mean BMI, serum creatinine, total cholesterol, TG, serum uric acid, and fasting blood glucose, as well as lower men age, and HDL-C than lower quantile group (P<0.05) . (2) Higher quantile group had higher mean 24-hour SBP and DBP, daytime SBP and DBP, nighttime SBP and DBP, nighttime heart rate and ba-PWV, and lower prevalence of nocturnal fall in SBP and DBP, and dippers than lower quantile group (P<0.05) . (3) Multiple linear regression analysis showed that, age〔β=12.35, 95%CI (10.307, 14.401) 〕, fasting blood glucose〔β=20.69, 95%CI (1.532, 39.854) 〕, TG/HDL-C ratio〔β=20.99, 95%CI (6.176, 35.810) 〕 and 24 hour mean SBP〔β=7.57, 95%CI (5.656, 9.493) 〕 were associated with ba-PWV (P<0.05) .ConclusionIn essential hypertension patients, elevated 24-hour SBP and DBP were found in those with higher TG/HDL-C ratio, and TG/HDL-C ratio may be independently associated with ba-PWV. Monitoring TG/HDL-C ratio helps early detection of arteriosclerosis and elevated blood pressure, promoting comprehensive management of cardiovascular risk factors.https://www.chinagp.net/fileup/1007-9572/PDF/1640772960809-1157370945.pdf|essential hypertension|triglyceride|cholesterol, hdl|ambulatory blood pressure monitoring|brachial-ankle pulse wave velocity|correlation of data |
| spellingShingle | ZENG Rong, ZHENG Keyang, YAN Jiafu, WANG Zuoguang, CHENG Wenli TG/HDL-C Ratio and ba-PWV in Patients with Essential Hypertension Zhongguo quanke yixue |essential hypertension|triglyceride|cholesterol, hdl|ambulatory blood pressure monitoring|brachial-ankle pulse wave velocity|correlation of data |
| title | TG/HDL-C Ratio and ba-PWV in Patients with
Essential Hypertension |
| title_full | TG/HDL-C Ratio and ba-PWV in Patients with
Essential Hypertension |
| title_fullStr | TG/HDL-C Ratio and ba-PWV in Patients with
Essential Hypertension |
| title_full_unstemmed | TG/HDL-C Ratio and ba-PWV in Patients with
Essential Hypertension |
| title_short | TG/HDL-C Ratio and ba-PWV in Patients with
Essential Hypertension |
| title_sort | tg hdl c ratio and ba pwv in patients with essential hypertension |
| topic | |essential hypertension|triglyceride|cholesterol, hdl|ambulatory blood pressure monitoring|brachial-ankle pulse wave velocity|correlation of data |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/1640772960809-1157370945.pdf |
| work_keys_str_mv | AT zengrongzhengkeyangyanjiafuwangzuoguangchengwenli tghdlcratioandbapwvinpatientswithessentialhypertension |