The effect of topical quercetin loaded liposome on pressure ulcer healing in rats
Objective(s): Quercetin antioxidant properties could play an important role in various fields of health. However, its use has been limited because of several disadvantages such as very low solubility in water and high instability in the presence of air, light and heat. Encapsulation of quercetin in...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-07-01
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| Series: | Nanomedicine Journal |
| Subjects: | |
| Online Access: | https://nmj.mums.ac.ir/article_18226_2e4216ec691688c89ece8f658152ca96.pdf |
| _version_ | 1818462034540363776 |
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| author | Neda Bavarsad Neda Sistani karampour Golnaz Hemmati Anahita Rezaie |
| author_facet | Neda Bavarsad Neda Sistani karampour Golnaz Hemmati Anahita Rezaie |
| author_sort | Neda Bavarsad |
| collection | DOAJ |
| description | Objective(s): Quercetin antioxidant properties could play an important role in various fields of health. However, its use has been limited because of several disadvantages such as very low solubility in water and high instability in the presence of air, light and heat. Encapsulation of quercetin in nanostructure systems such as liposome may lead to decrease the adverse effects and protect this molecule against degradation. The aim of this study was preparation and in-vitro and in-vivo evaluation of liposomes for topical delivery of quercetin to improve the pressure ulcers.Materials and Methods: Liposomal formulations were prepared by fusion method and characterized. The amount of drug retained in and penetrated through mouse skin after 8 hours were determined. Also microscopic and macroscopic examination of laboratory animals was performed.Results: Encapsulation efficacy of liposomes was in range 64.66-77.83%. Formulation F4 showed maximum drug release in 8 hours and the remaining drug in the skin layers was more than 46%. Histological investigation suggested that F4 and phenytoin 1% cream have the healing effect on the pressure ulcer during 28 day-treatment.Conclusion: Quercetin liposomes due to its natural structure and minimal systemic absorption and side effects can be a suitable candidate for the treatment of pressure ulcers. |
| first_indexed | 2024-12-14T23:55:37Z |
| format | Article |
| id | doaj.art-1d8655fd57f54d3797f323194b44a4c1 |
| institution | Directory Open Access Journal |
| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-12-14T23:55:37Z |
| publishDate | 2021-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-1d8655fd57f54d3797f323194b44a4c12022-12-21T22:43:08ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042021-07-018318719910.22038/nmj.2021.56952.158118226The effect of topical quercetin loaded liposome on pressure ulcer healing in ratsNeda Bavarsad0Neda Sistani karampour1Golnaz Hemmati2Anahita Rezaie3Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranStudent Research Committee, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranObjective(s): Quercetin antioxidant properties could play an important role in various fields of health. However, its use has been limited because of several disadvantages such as very low solubility in water and high instability in the presence of air, light and heat. Encapsulation of quercetin in nanostructure systems such as liposome may lead to decrease the adverse effects and protect this molecule against degradation. The aim of this study was preparation and in-vitro and in-vivo evaluation of liposomes for topical delivery of quercetin to improve the pressure ulcers.Materials and Methods: Liposomal formulations were prepared by fusion method and characterized. The amount of drug retained in and penetrated through mouse skin after 8 hours were determined. Also microscopic and macroscopic examination of laboratory animals was performed.Results: Encapsulation efficacy of liposomes was in range 64.66-77.83%. Formulation F4 showed maximum drug release in 8 hours and the remaining drug in the skin layers was more than 46%. Histological investigation suggested that F4 and phenytoin 1% cream have the healing effect on the pressure ulcer during 28 day-treatment.Conclusion: Quercetin liposomes due to its natural structure and minimal systemic absorption and side effects can be a suitable candidate for the treatment of pressure ulcers.https://nmj.mums.ac.ir/article_18226_2e4216ec691688c89ece8f658152ca96.pdffusionliposomepressure ulcerquercetintopical delivery |
| spellingShingle | Neda Bavarsad Neda Sistani karampour Golnaz Hemmati Anahita Rezaie The effect of topical quercetin loaded liposome on pressure ulcer healing in rats Nanomedicine Journal fusion liposome pressure ulcer quercetin topical delivery |
| title | The effect of topical quercetin loaded liposome on pressure ulcer healing in rats |
| title_full | The effect of topical quercetin loaded liposome on pressure ulcer healing in rats |
| title_fullStr | The effect of topical quercetin loaded liposome on pressure ulcer healing in rats |
| title_full_unstemmed | The effect of topical quercetin loaded liposome on pressure ulcer healing in rats |
| title_short | The effect of topical quercetin loaded liposome on pressure ulcer healing in rats |
| title_sort | effect of topical quercetin loaded liposome on pressure ulcer healing in rats |
| topic | fusion liposome pressure ulcer quercetin topical delivery |
| url | https://nmj.mums.ac.ir/article_18226_2e4216ec691688c89ece8f658152ca96.pdf |
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