Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy

Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the progressive loss of dopaminergic (DAergic) neurons in the ventral brain. A disaccharide trehalose has demonstrated the potential to mitigate the DAergic loss in disease models for PD. However, trehalose is rapidly hy...

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Main Authors: Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan Lin, Yen-Shi Lo, Jia-Li Lin, Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
lactulose and melibiose
MPTP mice
oxidative stress
neuroinflammation
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00226/full

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