Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A Review
ABSTRACT: Background: Overactive bladder (OAB) is a common clinical condition for which current drug treatment comprises drugs blocking the cholinergic nerve supply, or augmenting the adrenergic nerve supply, to the detrusor muscle of the urinary bladder. Current treatments have drawbacks, includin...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Therapeutic Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0011393X2200008X |
| _version_ | 1818194350868267008 |
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| author | Silvia Joseph, MBBS Steffi A. Maria, MD Jacob Peedicayil, MD |
| author_facet | Silvia Joseph, MBBS Steffi A. Maria, MD Jacob Peedicayil, MD |
| author_sort | Silvia Joseph, MBBS |
| collection | DOAJ |
| description | ABSTRACT: Background: Overactive bladder (OAB) is a common clinical condition for which current drug treatment comprises drugs blocking the cholinergic nerve supply, or augmenting the adrenergic nerve supply, to the detrusor muscle of the urinary bladder. Current treatments have drawbacks, including lack of efficacy and the development of adverse effects in some patients. Hence, new and better drugs for treating OAB will be clinically useful. Objective: This review is meant to provide information on drugs currently undergoing preclinical or clinical trials for the treatment of OAB published in journal articles or elsewhere. Methods: The cited articles were retrieved from PubMed and Google Scholar from January 1, 1990, to December 31, 2021. The search terms used were contraction or contractility, detrusor, inhibition, isolated or in vitro, in vivo, overactive bladder, and relaxant effect or relaxation. Results: There are 4 classes of new drugs under various stages of development for the treatment of OAB. These are drugs acting on the autonomic nerve supply to the detrusor muscle of the urinary bladder that include the anticholinergics tarafenacin and afacifenacin and the β3 adrenoceptor agonists solabegron and ritobegron; drugs acting on ion channels in the detrusor muscle (eg, potassium channel openers and calcium channel blockers), drugs acting on cellular enzymes like phosphodiesterase-5 inhibitors and Rho kinase inhibitors, and drugs acting on miscellaneous targets (eg, pregabalin and trimetazidine). Conclusions: Drugs currently used to treat OAB target only the cholinergic and adrenergic cellular signalling pathways. There are many other drugs under trial targeting other cellular pathways that may be useful for treating OAB. Their approval for clinical use might improve the treatment of patients with OAB. (Curr Ther Res Clin Exp. 2022; 83:XXX–XXX) |
| first_indexed | 2024-12-12T01:00:54Z |
| format | Article |
| id | doaj.art-1d898e004db74c3295f15419d3bc6d6f |
| institution | Directory Open Access Journal |
| issn | 0011-393X |
| language | English |
| last_indexed | 2024-12-12T01:00:54Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Therapeutic Research |
| spelling | doaj.art-1d898e004db74c3295f15419d3bc6d6f2022-12-22T00:43:44ZengElsevierCurrent Therapeutic Research0011-393X2022-01-0196100669Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A ReviewSilvia Joseph, MBBS0Steffi A. Maria, MD1Jacob Peedicayil, MD2Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaDepartment of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaAddress correspondence to: Jacob Peedicayil, MD, Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, India.; Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaABSTRACT: Background: Overactive bladder (OAB) is a common clinical condition for which current drug treatment comprises drugs blocking the cholinergic nerve supply, or augmenting the adrenergic nerve supply, to the detrusor muscle of the urinary bladder. Current treatments have drawbacks, including lack of efficacy and the development of adverse effects in some patients. Hence, new and better drugs for treating OAB will be clinically useful. Objective: This review is meant to provide information on drugs currently undergoing preclinical or clinical trials for the treatment of OAB published in journal articles or elsewhere. Methods: The cited articles were retrieved from PubMed and Google Scholar from January 1, 1990, to December 31, 2021. The search terms used were contraction or contractility, detrusor, inhibition, isolated or in vitro, in vivo, overactive bladder, and relaxant effect or relaxation. Results: There are 4 classes of new drugs under various stages of development for the treatment of OAB. These are drugs acting on the autonomic nerve supply to the detrusor muscle of the urinary bladder that include the anticholinergics tarafenacin and afacifenacin and the β3 adrenoceptor agonists solabegron and ritobegron; drugs acting on ion channels in the detrusor muscle (eg, potassium channel openers and calcium channel blockers), drugs acting on cellular enzymes like phosphodiesterase-5 inhibitors and Rho kinase inhibitors, and drugs acting on miscellaneous targets (eg, pregabalin and trimetazidine). Conclusions: Drugs currently used to treat OAB target only the cholinergic and adrenergic cellular signalling pathways. There are many other drugs under trial targeting other cellular pathways that may be useful for treating OAB. Their approval for clinical use might improve the treatment of patients with OAB. (Curr Ther Res Clin Exp. 2022; 83:XXX–XXX)http://www.sciencedirect.com/science/article/pii/S0011393X2200008Xcontractilitydetrusornew drugsoveractive bladderpharmacodynamics |
| spellingShingle | Silvia Joseph, MBBS Steffi A. Maria, MD Jacob Peedicayil, MD Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A Review Current Therapeutic Research contractility detrusor new drugs overactive bladder pharmacodynamics |
| title | Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A Review |
| title_full | Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A Review |
| title_fullStr | Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A Review |
| title_full_unstemmed | Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A Review |
| title_short | Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A Review |
| title_sort | drugs currently undergoing preclinical or clinical trials for the treatment of overactive bladder a review |
| topic | contractility detrusor new drugs overactive bladder pharmacodynamics |
| url | http://www.sciencedirect.com/science/article/pii/S0011393X2200008X |
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