Correlation between Troponin I, N-terminal pro–B-type natriuretic peptide, and left ventricular ejection fraction in acute coronary syndrome patients with mortality
Background: Troponin I (Trop 1) and N-terminal pro–B-type natriuretic peptide (NT-ProBNP) can be a discerning marker for the patients presenting with symptoms of acute cardiac ischemia and risk of death. The present study was to find a correlation between NT-ProBNP, troponin 1, and left ventricular...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Heart India |
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| Online Access: | http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=1;spage=18;epage=23;aulast=Pansuriya |
| _version_ | 1818721781769306112 |
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| author | Darshit Pansuriya Vrushali Khadke Arun Bahulikar Deepak Phalgune |
| author_facet | Darshit Pansuriya Vrushali Khadke Arun Bahulikar Deepak Phalgune |
| author_sort | Darshit Pansuriya |
| collection | DOAJ |
| description | Background: Troponin I (Trop 1) and N-terminal pro–B-type natriuretic peptide (NT-ProBNP) can be a discerning marker for the patients presenting with symptoms of acute cardiac ischemia and risk of death. The present study was to find a correlation between NT-ProBNP, troponin 1, and left ventricular ejection fraction (LVEF) in acute coronary syndrome (ACS) patients with mortality.
Methods: Ninety ACS patients >18 years of age were included for this prospective observational study. Each patient was subjected to detailed clinical history, clinical examination, Trop I, NT-ProBNP, and LVEF at the time of admission. The primary outcome measures were to study the correlation of NT-ProBNP and Trop I and LVEF at the time of admission with mortality, whereas the secondary outcome measure was to study LVEF after ACS up to 1 month. Medians of continuous variables of two groups and three groups were tested.
Results: The median Trop 1 levels were 12.0, 378.0, and 2454.0 in patients of unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI), respectively (P = 0.001). The median NT-ProBNP levels were 1027.0, 1494.0, and 3728.5 in patients of UA, NSTEMI and STEMI, respectively (P = 0.002). The median Trop 1 levels were 5433.0, 627.5, and 92.0 in patients whose LVEF was <40%, 40%–50%, and >50%, respectively (P = 0.001). The median NT-ProBNP levels were 14,554.0, 2009.0, and 306.0 in patients whose LVEF was <40%, 40%–50%, and >50%, respectively (P = 0.001). The median Trop 1 levels were 11439.0 and 570.0 in patients who expired and survived, respectively (P = 0.001). The median NT-ProBNP levels were 21047.0 and 1869.5 in patients who expired and survived, respectively (P = 0.001). The median LVEF were 30.0 and 45.0 in patients who expired and survived, respectively (P = 0.001). Trop I showed a significant positive correlation (r = 0.636) with NT-ProBNP levels (P < 0.001).
Conclusion: Trop I, NT-ProBNP, and LVEF at the time of admission are strong predictors of 1-month mortality in ACS. |
| first_indexed | 2024-12-17T20:44:11Z |
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| id | doaj.art-1d8ad23dfbd94e67a7b2f5f3244b3c9f |
| institution | Directory Open Access Journal |
| issn | 2321-449X |
| language | English |
| last_indexed | 2024-12-17T20:44:11Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Heart India |
| spelling | doaj.art-1d8ad23dfbd94e67a7b2f5f3244b3c9f2022-12-21T21:33:12ZengWolters Kluwer Medknow PublicationsHeart India2321-449X2021-01-0191182310.4103/heartindia.heartindia_50_20Correlation between Troponin I, N-terminal pro–B-type natriuretic peptide, and left ventricular ejection fraction in acute coronary syndrome patients with mortalityDarshit PansuriyaVrushali KhadkeArun BahulikarDeepak PhalguneBackground: Troponin I (Trop 1) and N-terminal pro–B-type natriuretic peptide (NT-ProBNP) can be a discerning marker for the patients presenting with symptoms of acute cardiac ischemia and risk of death. The present study was to find a correlation between NT-ProBNP, troponin 1, and left ventricular ejection fraction (LVEF) in acute coronary syndrome (ACS) patients with mortality. Methods: Ninety ACS patients >18 years of age were included for this prospective observational study. Each patient was subjected to detailed clinical history, clinical examination, Trop I, NT-ProBNP, and LVEF at the time of admission. The primary outcome measures were to study the correlation of NT-ProBNP and Trop I and LVEF at the time of admission with mortality, whereas the secondary outcome measure was to study LVEF after ACS up to 1 month. Medians of continuous variables of two groups and three groups were tested. Results: The median Trop 1 levels were 12.0, 378.0, and 2454.0 in patients of unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI), respectively (P = 0.001). The median NT-ProBNP levels were 1027.0, 1494.0, and 3728.5 in patients of UA, NSTEMI and STEMI, respectively (P = 0.002). The median Trop 1 levels were 5433.0, 627.5, and 92.0 in patients whose LVEF was <40%, 40%–50%, and >50%, respectively (P = 0.001). The median NT-ProBNP levels were 14,554.0, 2009.0, and 306.0 in patients whose LVEF was <40%, 40%–50%, and >50%, respectively (P = 0.001). The median Trop 1 levels were 11439.0 and 570.0 in patients who expired and survived, respectively (P = 0.001). The median NT-ProBNP levels were 21047.0 and 1869.5 in patients who expired and survived, respectively (P = 0.001). The median LVEF were 30.0 and 45.0 in patients who expired and survived, respectively (P = 0.001). Trop I showed a significant positive correlation (r = 0.636) with NT-ProBNP levels (P < 0.001). Conclusion: Trop I, NT-ProBNP, and LVEF at the time of admission are strong predictors of 1-month mortality in ACS.http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=1;spage=18;epage=23;aulast=Pansuriyaacute coronary syndromecorrelationleft ventricular ejection fractionmortalityn-terminal pro–b-type natriuretic peptidetroponin i |
| spellingShingle | Darshit Pansuriya Vrushali Khadke Arun Bahulikar Deepak Phalgune Correlation between Troponin I, N-terminal pro–B-type natriuretic peptide, and left ventricular ejection fraction in acute coronary syndrome patients with mortality Heart India acute coronary syndrome correlation left ventricular ejection fraction mortality n-terminal pro–b-type natriuretic peptide troponin i |
| title | Correlation between Troponin I, N-terminal pro–B-type natriuretic peptide, and left ventricular ejection fraction in acute coronary syndrome patients with mortality |
| title_full | Correlation between Troponin I, N-terminal pro–B-type natriuretic peptide, and left ventricular ejection fraction in acute coronary syndrome patients with mortality |
| title_fullStr | Correlation between Troponin I, N-terminal pro–B-type natriuretic peptide, and left ventricular ejection fraction in acute coronary syndrome patients with mortality |
| title_full_unstemmed | Correlation between Troponin I, N-terminal pro–B-type natriuretic peptide, and left ventricular ejection fraction in acute coronary syndrome patients with mortality |
| title_short | Correlation between Troponin I, N-terminal pro–B-type natriuretic peptide, and left ventricular ejection fraction in acute coronary syndrome patients with mortality |
| title_sort | correlation between troponin i n terminal pro b type natriuretic peptide and left ventricular ejection fraction in acute coronary syndrome patients with mortality |
| topic | acute coronary syndrome correlation left ventricular ejection fraction mortality n-terminal pro–b-type natriuretic peptide troponin i |
| url | http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=1;spage=18;epage=23;aulast=Pansuriya |
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