Effect of metformin on the anti-Müllerian hormone level in infertile women with polycystic ovarian syndrome
Background: Polycystic ovary syndrome (PCOS) is the major cause of anovulatory infertility in women. The level of serum Anti-Mullerian Hormone (AMH) in patients can be 2-3 times higher than in healthy women. The aim of this study was to assess the effect of metformin on AMH level in PCOS patients...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Electronic Physician
2017-12-01
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| Series: | Electronic Physician |
| Subjects: | |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843423/ |
| Summary: | Background: Polycystic ovary syndrome (PCOS) is the major cause of anovulatory infertility in women. The
level of serum Anti-Mullerian Hormone (AMH) in patients can be 2-3 times higher than in healthy women. The
aim of this study was to assess the effect of metformin on AMH level in PCOS patients suffering from infertility.
Methods: In this pre and post clinical trial, 30 infertile patients with PCOS were enrolled according to the
Rotterdam criteria. The serum AMH level was recorded before and after 8 weeks of treatment with metformin
(1500 mg daily). We used SPSS version 17 and paired samples t-test, multiple linear regression and ANCOVA
test for data analysis.
Results: Serum AMH level was significantly decreased after 8 weeks of treatment with metformin [10±3.75
(ng/ml) versus 7.8±3.7 (ng/ml)] (p=0.008, 95% CI: 0.60-3.75). Also, AMH level change was directly associated
to BMI in PCOS patients. In other words, in these patients, a higher BMI led to more decrease in AMH level after
metformin treatment.
Conclusion: Eight weeks’ treatment with metformin would significantly decrease AMH. AMH level change was
directly associated to BMI.
Clinical trial registration: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir)
with the Irct ID: 201403132967N5
Funding: This study was funded by the Department of Gynecology and Obstetrics, School of Medicine, Kashan
University of Medical Sciences (Grant Number: 9322). |
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| ISSN: | 2008-5842 2008-5842 |