EFFECTS OF RESVERATROL ON LIVER FUNCTION OF OBESE FEMALE WISTAR RATS
Resveratrol has antioxidant, anti-inflammatory, lipolytic, and antifibrotic properties, which may be useful in supplementation of obese patients and with liver problems. This study evaluated the effects of 6-week resveratrol supplementation on the lipid profile and liver function of female Wistar r...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Goiás
2016-07-01
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| Series: | Ciência Animal Brasileira |
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| Online Access: | https://revistas.ufg.br/vet/article/view/32990 |
| _version_ | 1797793013604286464 |
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| author | Nádia Araújo Miguel Silvia Franco Andrade Gisele Nai Cecília Braga Laposy Felipe Franco Nascimento Heloise Rangel Dinallo Alessandra Melchert |
| author_facet | Nádia Araújo Miguel Silvia Franco Andrade Gisele Nai Cecília Braga Laposy Felipe Franco Nascimento Heloise Rangel Dinallo Alessandra Melchert |
| author_sort | Nádia Araújo Miguel |
| collection | DOAJ |
| description |
Resveratrol has antioxidant, anti-inflammatory, lipolytic, and antifibrotic properties, which may be useful in supplementation of obese patients and with liver problems. This study evaluated the effects of 6-week resveratrol supplementation on the lipid profile and liver function of female Wistar rats fed a high-fat diet to induce obesity. Sixty-four Wistar rats were divided into 4 groups (n = 16): the control group (C); the control obese group (CO); the resveratrol group (R); and the resveratrol obese group (RO). At the end of the experiment, the animals were anesthetized for blood collection and subsequent euthanasia for collection of liver biopsy. The parameters for body weight, liver weight, retroperitoneal fat weight, serum lipid and liver profiles and histopathological analysis were evaluated. The 6-week resveratrol administration did not induce weight loss nor did it reduce the lipid profile; however, it decreased the liver enzymes aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and reduced the incidence of steatosis (75.0%) in group RO compared with group CO (81.2%). Thus, we concluded that resveratrol supplementation for the short period of six weeks had a beneficial effect on liver function by reducing hepatic steatosis and the liver enzymes AST and ALP in obese female rats.
Keywords: liver function; obesity; rats; resveratrol.
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| first_indexed | 2024-03-13T02:42:07Z |
| format | Article |
| id | doaj.art-1d8cbe48ad314dcbb515c369d90f2656 |
| institution | Directory Open Access Journal |
| issn | 1518-2797 1809-6891 |
| language | English |
| last_indexed | 2024-03-13T02:42:07Z |
| publishDate | 2016-07-01 |
| publisher | Universidade Federal de Goiás |
| record_format | Article |
| series | Ciência Animal Brasileira |
| spelling | doaj.art-1d8cbe48ad314dcbb515c369d90f26562023-06-28T21:09:03ZengUniversidade Federal de GoiásCiência Animal Brasileira1518-27971809-68912016-07-0117310.1590/cab17332990EFFECTS OF RESVERATROL ON LIVER FUNCTION OF OBESE FEMALE WISTAR RATSNádia Araújo Miguel0Silvia Franco Andrade1Gisele Nai2Cecília Braga Laposy3Felipe Franco Nascimento4Heloise Rangel Dinallo5Alessandra Melchert6Universidade do Oeste Paulista (UNOESTE)Universidade do Oeste Paulista (UNOESTE)Universidade do Oeste PaulistaUniversidade do Oeste Paulista (UNOESTE)Universidade do Oeste Paulista (UNOESTE)Universidade do Oeste Paulista (UNOESTE)Universidade Estadual Paulista-UNESP-Botucatu Resveratrol has antioxidant, anti-inflammatory, lipolytic, and antifibrotic properties, which may be useful in supplementation of obese patients and with liver problems. This study evaluated the effects of 6-week resveratrol supplementation on the lipid profile and liver function of female Wistar rats fed a high-fat diet to induce obesity. Sixty-four Wistar rats were divided into 4 groups (n = 16): the control group (C); the control obese group (CO); the resveratrol group (R); and the resveratrol obese group (RO). At the end of the experiment, the animals were anesthetized for blood collection and subsequent euthanasia for collection of liver biopsy. The parameters for body weight, liver weight, retroperitoneal fat weight, serum lipid and liver profiles and histopathological analysis were evaluated. The 6-week resveratrol administration did not induce weight loss nor did it reduce the lipid profile; however, it decreased the liver enzymes aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and reduced the incidence of steatosis (75.0%) in group RO compared with group CO (81.2%). Thus, we concluded that resveratrol supplementation for the short period of six weeks had a beneficial effect on liver function by reducing hepatic steatosis and the liver enzymes AST and ALP in obese female rats. Keywords: liver function; obesity; rats; resveratrol. https://revistas.ufg.br/vet/article/view/32990Animal Nutrition |
| spellingShingle | Nádia Araújo Miguel Silvia Franco Andrade Gisele Nai Cecília Braga Laposy Felipe Franco Nascimento Heloise Rangel Dinallo Alessandra Melchert EFFECTS OF RESVERATROL ON LIVER FUNCTION OF OBESE FEMALE WISTAR RATS Ciência Animal Brasileira Animal Nutrition |
| title | EFFECTS OF RESVERATROL ON LIVER FUNCTION OF OBESE FEMALE WISTAR RATS |
| title_full | EFFECTS OF RESVERATROL ON LIVER FUNCTION OF OBESE FEMALE WISTAR RATS |
| title_fullStr | EFFECTS OF RESVERATROL ON LIVER FUNCTION OF OBESE FEMALE WISTAR RATS |
| title_full_unstemmed | EFFECTS OF RESVERATROL ON LIVER FUNCTION OF OBESE FEMALE WISTAR RATS |
| title_short | EFFECTS OF RESVERATROL ON LIVER FUNCTION OF OBESE FEMALE WISTAR RATS |
| title_sort | effects of resveratrol on liver function of obese female wistar rats |
| topic | Animal Nutrition |
| url | https://revistas.ufg.br/vet/article/view/32990 |
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