Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN)
Background: Management of gastric and gastroesophageal junction (GEJ) adenocarcinoma remains challenging, because of the heterogeneity in tumor biology within the upper gastrointestinal tract. Daily clinical practice is full of grey areas regarding the complexity of diagnostic, staging, and therapeu...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/6/1304 |
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| author | Lorenzo Fornaro Andrea Spallanzani Ferdinando de Vita Domenico D’Ugo Alfredo Falcone Laura Lorenzon Giuseppe Tirino Stefano Cascinu on behalf of GAIN (GAstric Cancer Italian Network) |
| author_facet | Lorenzo Fornaro Andrea Spallanzani Ferdinando de Vita Domenico D’Ugo Alfredo Falcone Laura Lorenzon Giuseppe Tirino Stefano Cascinu on behalf of GAIN (GAstric Cancer Italian Network) |
| author_sort | Lorenzo Fornaro |
| collection | DOAJ |
| description | Background: Management of gastric and gastroesophageal junction (GEJ) adenocarcinoma remains challenging, because of the heterogeneity in tumor biology within the upper gastrointestinal tract. Daily clinical practice is full of grey areas regarding the complexity of diagnostic, staging, and therapeutic procedures. The aim of this paper is to provide a guide for clinicians facing challenging situations in routine practice, taking a multidisciplinary consensus approach based on available literature. Methods: The GAIN (GAstric cancer Italian Network) group was established with the aims of reviewing literature evidence, discussing key issues in prevention, diagnosis, and management of gastric and GEJ adenocarcinoma, and offering a summary of statements. A Delphi consensus method was used to obtain opinions from the expert panel of specialists. Results: Forty-nine clinical questions were identified in six areas of interest: role of multidisciplinary team; risk factors; diagnosis; management of early gastric cancer and multimodal approach to localized gastric cancer; treatment of elderly patients with locally advanced resectable disease; and treatment of locally advanced and metastatic cancer. Conclusions: The statements presented may guide clinicians in practical management of this disease. |
| first_indexed | 2024-03-10T13:14:14Z |
| format | Article |
| id | doaj.art-1d8d1c264d1f4f08917b21f1444abb61 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:14:14Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1d8d1c264d1f4f08917b21f1444abb612023-11-21T10:31:40ZengMDPI AGCancers2072-66942021-03-01136130410.3390/cancers13061304Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN)Lorenzo Fornaro0Andrea Spallanzani1Ferdinando de Vita2Domenico D’Ugo3Alfredo Falcone4Laura Lorenzon5Giuseppe Tirino6Stefano Cascinu7on behalf of GAIN (GAstric Cancer Italian Network)Department of Translational Medicine, Division of Medical Oncology, AOU Pisana, 56126 Pisa, ItalyDepartment of Oncology and Hematology, University Hospital of Modena, 41125 Modena, ItalyDepartment of Precision Medicine, Division of Medical Oncology, School of Medicine, University of Campania ‘Luigi Vanvitelli’, 81100 Caserta, ItalyGeneral Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University, 00168 Rome, ItalyDepartment of Translational Medicine, Division of Medical Oncology, University of Pisa, 56126 Pisa, ItalyGeneral Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University, 00168 Rome, ItalyDepartment of Precision Medicine, Division of Medical Oncology, School of Medicine, University of Campania ‘Luigi Vanvitelli’, 81100 Caserta, ItalyMedical Oncology, Università Vita-Salute San Raffaele, 20132 Milan, ItalyBackground: Management of gastric and gastroesophageal junction (GEJ) adenocarcinoma remains challenging, because of the heterogeneity in tumor biology within the upper gastrointestinal tract. Daily clinical practice is full of grey areas regarding the complexity of diagnostic, staging, and therapeutic procedures. The aim of this paper is to provide a guide for clinicians facing challenging situations in routine practice, taking a multidisciplinary consensus approach based on available literature. Methods: The GAIN (GAstric cancer Italian Network) group was established with the aims of reviewing literature evidence, discussing key issues in prevention, diagnosis, and management of gastric and GEJ adenocarcinoma, and offering a summary of statements. A Delphi consensus method was used to obtain opinions from the expert panel of specialists. Results: Forty-nine clinical questions were identified in six areas of interest: role of multidisciplinary team; risk factors; diagnosis; management of early gastric cancer and multimodal approach to localized gastric cancer; treatment of elderly patients with locally advanced resectable disease; and treatment of locally advanced and metastatic cancer. Conclusions: The statements presented may guide clinicians in practical management of this disease.https://www.mdpi.com/2072-6694/13/6/1304gastric cancerGEJ adenocarcinomarecommendationstreatmentdiagnosis |
| spellingShingle | Lorenzo Fornaro Andrea Spallanzani Ferdinando de Vita Domenico D’Ugo Alfredo Falcone Laura Lorenzon Giuseppe Tirino Stefano Cascinu on behalf of GAIN (GAstric Cancer Italian Network) Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN) Cancers gastric cancer GEJ adenocarcinoma recommendations treatment diagnosis |
| title | Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN) |
| title_full | Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN) |
| title_fullStr | Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN) |
| title_full_unstemmed | Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN) |
| title_short | Beyond the Guidelines: The Grey Zones of the Management of Gastric Cancer. Consensus Statements from the Gastric Cancer Italian Network (GAIN) |
| title_sort | beyond the guidelines the grey zones of the management of gastric cancer consensus statements from the gastric cancer italian network gain |
| topic | gastric cancer GEJ adenocarcinoma recommendations treatment diagnosis |
| url | https://www.mdpi.com/2072-6694/13/6/1304 |
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