Matrix metalloprotein-triggered, cell penetrating peptide-modified star-shaped nanoparticles for tumor targeting and cancer therapy

Matrix metalloprotein-triggered, cell penetrating peptide-modified star-shaped nanoparticles for tumor targeting and cancer therapy

Abstract Background Specific targeting ability and good cell penetration are two critical requirements of tumor-targeted delivery systems. In the present work, we developed a novel matrix metalloprotein-triggered, cell-penetrating, peptide-modified, star-shaped nanoparticle (NP) based on a functiona...

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Bibliographic Details
Main Authors: Fangyuan Guo, Qiafan Fu, Kang Zhou, Chenghao Jin, Wenchao Wu, Xugang Ji, Qinying Yan, Qingliang Yang, Danjun Wu, Aiqin Li, Gensheng Yang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Nanobiotechnology
Subjects:
Cell-penetrating peptide
Cleavable peptide
Matrix metalloproteinase
Enzyme-responsive nanoparticles
Targeted drug delivery
Online Access:http://link.springer.com/article/10.1186/s12951-020-00595-5

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