Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland
Human mammaglobin-A (SCGB2A2) is a secretory protein with an unknown function that is used as a diagnostic marker for breast cancer. However, other tumors can also express mammaglobin-A. To comprehensively study patterns of mammaglobin-A expression, a tissue microarray containing 16,328 samples from...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/6/1202 |
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| author | Natalia Gorbokon Patrick Timm David Dum Anne Menz Franziska Büscheck Cosima Völkel Andrea Hinsch Maximilian Lennartz Andreas M Luebke Claudia Hube-Magg Christoph Fraune Till Krech Patrick Lebok Till S Clauditz Frank Jacobsen Guido Sauter Ria Uhlig Stefan Steurer Sarah Minner Andreas H. Marx Ronald Simon Eike Burandt Christian Bernreuther Doris Höflmayer |
| author_facet | Natalia Gorbokon Patrick Timm David Dum Anne Menz Franziska Büscheck Cosima Völkel Andrea Hinsch Maximilian Lennartz Andreas M Luebke Claudia Hube-Magg Christoph Fraune Till Krech Patrick Lebok Till S Clauditz Frank Jacobsen Guido Sauter Ria Uhlig Stefan Steurer Sarah Minner Andreas H. Marx Ronald Simon Eike Burandt Christian Bernreuther Doris Höflmayer |
| author_sort | Natalia Gorbokon |
| collection | DOAJ |
| description | Human mammaglobin-A (SCGB2A2) is a secretory protein with an unknown function that is used as a diagnostic marker for breast cancer. However, other tumors can also express mammaglobin-A. To comprehensively study patterns of mammaglobin-A expression, a tissue microarray containing 16,328 samples from 128 different tumor types as well as 608 samples of 76 different normal tissue types was analyzed using immunohistochemistry. Mammaglobin-A positivity was found in only a few normal tissues, including luminal cells of the breast as well as endocervical and endometrial glands. In tumor tissues, 37 of 128 tumor categories showed mamma-globin-A staining, 32 of which were derived from one of four organs: breast (6 tumor categories), endometrium (5 tumor categories), ovary (5 tumor categories), and salivary glands (16 tumor categories). Only five additional tumor types showed occasional weak mammaglobin positivity, including medullary thyroid cancer, teratoma of the testis, squamous cell carcinoma of the skin and pharynx, and prostatic adenocarcinoma. Among 1139 evaluable invasive breast carcinomas of no special type, low mammaglobin-A immunostaining was linked to high BRE grade (<i>p</i> = 0.0011), loss of estrogen and progesterone receptor expression (<i>p</i> < 0.0001 each), and triple-negative status (<i>p</i> < 0.0001) but not to patient survival. In endometrial cancer, mammaglobin-A loss was linked to an advanced tumor stage (<i>p</i> = 0.0198). Our data characterize mammaglobin-A as a highly specific marker for tumors derived from either the breast, female genitals, or salivary gland. |
| first_indexed | 2024-03-11T06:40:35Z |
| format | Article |
| id | doaj.art-1d8e6c2772a8465aa296c99a58ed92a5 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T06:40:35Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1d8e6c2772a8465aa296c99a58ed92a52023-11-17T10:35:44ZengMDPI AGDiagnostics2075-44182023-03-01136120210.3390/diagnostics13061202Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary GlandNatalia Gorbokon0Patrick Timm1David Dum2Anne Menz3Franziska Büscheck4Cosima Völkel5Andrea Hinsch6Maximilian Lennartz7Andreas M Luebke8Claudia Hube-Magg9Christoph Fraune10Till Krech11Patrick Lebok12Till S Clauditz13Frank Jacobsen14Guido Sauter15Ria Uhlig16Stefan Steurer17Sarah Minner18Andreas H. Marx19Ronald Simon20Eike Burandt21Christian Bernreuther22Doris Höflmayer23Institute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyInstitute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyHuman mammaglobin-A (SCGB2A2) is a secretory protein with an unknown function that is used as a diagnostic marker for breast cancer. However, other tumors can also express mammaglobin-A. To comprehensively study patterns of mammaglobin-A expression, a tissue microarray containing 16,328 samples from 128 different tumor types as well as 608 samples of 76 different normal tissue types was analyzed using immunohistochemistry. Mammaglobin-A positivity was found in only a few normal tissues, including luminal cells of the breast as well as endocervical and endometrial glands. In tumor tissues, 37 of 128 tumor categories showed mamma-globin-A staining, 32 of which were derived from one of four organs: breast (6 tumor categories), endometrium (5 tumor categories), ovary (5 tumor categories), and salivary glands (16 tumor categories). Only five additional tumor types showed occasional weak mammaglobin positivity, including medullary thyroid cancer, teratoma of the testis, squamous cell carcinoma of the skin and pharynx, and prostatic adenocarcinoma. Among 1139 evaluable invasive breast carcinomas of no special type, low mammaglobin-A immunostaining was linked to high BRE grade (<i>p</i> = 0.0011), loss of estrogen and progesterone receptor expression (<i>p</i> < 0.0001 each), and triple-negative status (<i>p</i> < 0.0001) but not to patient survival. In endometrial cancer, mammaglobin-A loss was linked to an advanced tumor stage (<i>p</i> = 0.0198). Our data characterize mammaglobin-A as a highly specific marker for tumors derived from either the breast, female genitals, or salivary gland.https://www.mdpi.com/2075-4418/13/6/1202mammaglobin-Aimmunohistochemistrytissue microarraydiagnostic markerhuman cancers |
| spellingShingle | Natalia Gorbokon Patrick Timm David Dum Anne Menz Franziska Büscheck Cosima Völkel Andrea Hinsch Maximilian Lennartz Andreas M Luebke Claudia Hube-Magg Christoph Fraune Till Krech Patrick Lebok Till S Clauditz Frank Jacobsen Guido Sauter Ria Uhlig Stefan Steurer Sarah Minner Andreas H. Marx Ronald Simon Eike Burandt Christian Bernreuther Doris Höflmayer Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland Diagnostics mammaglobin-A immunohistochemistry tissue microarray diagnostic marker human cancers |
| title | Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland |
| title_full | Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland |
| title_fullStr | Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland |
| title_full_unstemmed | Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland |
| title_short | Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland |
| title_sort | mammaglobin a expression is highly specific for tumors derived from the breast the female genital tract and the salivary gland |
| topic | mammaglobin-A immunohistochemistry tissue microarray diagnostic marker human cancers |
| url | https://www.mdpi.com/2075-4418/13/6/1202 |
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