Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering
Bone tissue engineering offers versatile solutions to broaden clinical options for treating skeletal injuries. However, the variety of robust bone implants and substitutes remains largely uninvestigated. The advancements in hydrogel scaffolds composed of natural polymeric materials and osteoinductiv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/8/11/169 |
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| author | Darlin Lantigua Xinchen Wu Sanika Suvarnapathaki Michelle A. Nguyen Gulden Camci-Unal |
| author_facet | Darlin Lantigua Xinchen Wu Sanika Suvarnapathaki Michelle A. Nguyen Gulden Camci-Unal |
| author_sort | Darlin Lantigua |
| collection | DOAJ |
| description | Bone tissue engineering offers versatile solutions to broaden clinical options for treating skeletal injuries. However, the variety of robust bone implants and substitutes remains largely uninvestigated. The advancements in hydrogel scaffolds composed of natural polymeric materials and osteoinductive microparticles have shown to be promising solutions in this field. In this study, gelatin methacrylate (GelMA) hydrogels containing bone meal powder (BP) particles were investigated for their osteoinductive capacity. As natural source of the bone mineral, we expect that BP improves the scaffold’s ability to induce mineralization. We characterized the physical properties of GelMA hydrogels containing various BP concentrations (0, 0.5, 5, and 50 mg/mL). The in vitro cellular studies revealed enhanced mechanical performance and the potential to promote the differentiation of pre-osteoblast cells. The in vivo studies demonstrated both promising biocompatibility and biodegradation properties. Overall, the biological and physical properties of this biomaterial is tunable based on BP concentration in GelMA scaffolds. The findings of this study offer a new composite scaffold for bone tissue engineering. |
| first_indexed | 2024-03-10T05:41:55Z |
| format | Article |
| id | doaj.art-1d9256b6e6c445cdbc0603bc93324d29 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T05:41:55Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-1d9256b6e6c445cdbc0603bc93324d292023-11-22T22:26:36ZengMDPI AGBioengineering2306-53542021-11-0181116910.3390/bioengineering8110169Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue EngineeringDarlin Lantigua0Xinchen Wu1Sanika Suvarnapathaki2Michelle A. Nguyen3Gulden Camci-Unal4Biomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USABiomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USABiomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USADepartment of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USADepartment of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USABone tissue engineering offers versatile solutions to broaden clinical options for treating skeletal injuries. However, the variety of robust bone implants and substitutes remains largely uninvestigated. The advancements in hydrogel scaffolds composed of natural polymeric materials and osteoinductive microparticles have shown to be promising solutions in this field. In this study, gelatin methacrylate (GelMA) hydrogels containing bone meal powder (BP) particles were investigated for their osteoinductive capacity. As natural source of the bone mineral, we expect that BP improves the scaffold’s ability to induce mineralization. We characterized the physical properties of GelMA hydrogels containing various BP concentrations (0, 0.5, 5, and 50 mg/mL). The in vitro cellular studies revealed enhanced mechanical performance and the potential to promote the differentiation of pre-osteoblast cells. The in vivo studies demonstrated both promising biocompatibility and biodegradation properties. Overall, the biological and physical properties of this biomaterial is tunable based on BP concentration in GelMA scaffolds. The findings of this study offer a new composite scaffold for bone tissue engineering.https://www.mdpi.com/2306-5354/8/11/169hydrogelsscaffoldsbonephotocrosslinkingtissue engineering |
| spellingShingle | Darlin Lantigua Xinchen Wu Sanika Suvarnapathaki Michelle A. Nguyen Gulden Camci-Unal Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering Bioengineering hydrogels scaffolds bone photocrosslinking tissue engineering |
| title | Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering |
| title_full | Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering |
| title_fullStr | Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering |
| title_full_unstemmed | Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering |
| title_short | Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering |
| title_sort | composite scaffolds from gelatin and bone meal powder for tissue engineering |
| topic | hydrogels scaffolds bone photocrosslinking tissue engineering |
| url | https://www.mdpi.com/2306-5354/8/11/169 |
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