Perceptually relevant remapping of human somatotopy in 24 hours
Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/17280 |
| _version_ | 1811236920936628224 |
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| author | James Kolasinski Tamar R Makin John P Logan Saad Jbabdi Stuart Clare Charlotte J Stagg Heidi Johansen-Berg |
| author_facet | James Kolasinski Tamar R Makin John P Logan Saad Jbabdi Stuart Clare Charlotte J Stagg Heidi Johansen-Berg |
| author_sort | James Kolasinski |
| collection | DOAJ |
| description | Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects of a 24 hr gluing manipulation in which the right index and right middle fingers (digits 2 and 3) were adjoined with surgical glue. Somatotopic representations, assessed with two 7 tesla fMRI protocols, revealed rapid off-target reorganisation in the non-manipulated fingers following gluing, with the representation of the ring finger (digit 4) shifted towards the little finger (digit 5) and away from the middle finger (digit 3). These shifts were also evident in two behavioural tasks conducted in an independent cohort, showing reduced sensitivity for discriminating the temporal order of stimuli to the ring and little fingers, and increased substitution errors across this pair on a speeded reaction time task. |
| first_indexed | 2024-04-12T12:17:28Z |
| format | Article |
| id | doaj.art-1d936db0bfc742fc8d220e4eed276909 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:17:28Z |
| publishDate | 2016-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1d936db0bfc742fc8d220e4eed2769092022-12-22T03:33:23ZengeLife Sciences Publications LtdeLife2050-084X2016-12-01510.7554/eLife.17280Perceptually relevant remapping of human somatotopy in 24 hoursJames Kolasinski0https://orcid.org/0000-0002-1599-6440Tamar R Makin1https://orcid.org/0000-0002-5816-8979John P Logan2https://orcid.org/0000-0002-4469-2948Saad Jbabdi3Stuart Clare4Charlotte J Stagg5Heidi Johansen-Berg6Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; University College, Oxford, United KingdomOxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Institute of Cognitive Neuroscience, University College London, London, United KingdomOxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomOxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomOxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomOxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, United KingdomOxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomExperience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects of a 24 hr gluing manipulation in which the right index and right middle fingers (digits 2 and 3) were adjoined with surgical glue. Somatotopic representations, assessed with two 7 tesla fMRI protocols, revealed rapid off-target reorganisation in the non-manipulated fingers following gluing, with the representation of the ring finger (digit 4) shifted towards the little finger (digit 5) and away from the middle finger (digit 3). These shifts were also evident in two behavioural tasks conducted in an independent cohort, showing reduced sensitivity for discriminating the temporal order of stimuli to the ring and little fingers, and increased substitution errors across this pair on a speeded reaction time task.https://elifesciences.org/articles/17280somatosensoryplasticitytopography |
| spellingShingle | James Kolasinski Tamar R Makin John P Logan Saad Jbabdi Stuart Clare Charlotte J Stagg Heidi Johansen-Berg Perceptually relevant remapping of human somatotopy in 24 hours eLife somatosensory plasticity topography |
| title | Perceptually relevant remapping of human somatotopy in 24 hours |
| title_full | Perceptually relevant remapping of human somatotopy in 24 hours |
| title_fullStr | Perceptually relevant remapping of human somatotopy in 24 hours |
| title_full_unstemmed | Perceptually relevant remapping of human somatotopy in 24 hours |
| title_short | Perceptually relevant remapping of human somatotopy in 24 hours |
| title_sort | perceptually relevant remapping of human somatotopy in 24 hours |
| topic | somatosensory plasticity topography |
| url | https://elifesciences.org/articles/17280 |
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