Longitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury
In hospitalized COVID-19 patients, disease progression leading to acute kidney injury (AKI) may be driven by immune dysregulation. We explored the role of urinary cytokines and their relationship with kidney stress biomarkers in COVID-19 patients before and after the development of AKI. Of 51 patien...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/23/15419 |
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| author | Gustavo Casas-Aparicio Claudia Alvarado-de la Barrera David Escamilla-Illescas Isabel León-Rodríguez Perla Mariana Del Río-Estrada Mauricio González-Navarro Natalia Calderón-Dávila Rossana Olmedo-Ocampo Manuel Castillejos-López Liliana Figueroa-Hernández Amy B. Peralta-Prado Yara Luna-Villalobos Elvira Piten-Isidro Paola Fernández-Campos Alejandro Juárez-Díaz Karolina Piekarska Santiago Ávila-Ríos |
| author_facet | Gustavo Casas-Aparicio Claudia Alvarado-de la Barrera David Escamilla-Illescas Isabel León-Rodríguez Perla Mariana Del Río-Estrada Mauricio González-Navarro Natalia Calderón-Dávila Rossana Olmedo-Ocampo Manuel Castillejos-López Liliana Figueroa-Hernández Amy B. Peralta-Prado Yara Luna-Villalobos Elvira Piten-Isidro Paola Fernández-Campos Alejandro Juárez-Díaz Karolina Piekarska Santiago Ávila-Ríos |
| author_sort | Gustavo Casas-Aparicio |
| collection | DOAJ |
| description | In hospitalized COVID-19 patients, disease progression leading to acute kidney injury (AKI) may be driven by immune dysregulation. We explored the role of urinary cytokines and their relationship with kidney stress biomarkers in COVID-19 patients before and after the development of AKI. Of 51 patients, 54.9% developed AKI. The principal component analysis indicated that in subclinical AKI, epidermal growth factor (EGF) and interferon (IFN)-α were associated with a lower risk of AKI, while interleukin-12 (IL-12) and macrophage inflammatory protein (MIP)-1β were associated with a higher risk of AKI. After the manifestation of AKI, EGF and IFN-α remained associated with a lower risk of AKI, while IL-1 receptor (IL-1R), granulocyte-colony stimulating factor (G-CSF), interferon-gamma-inducible protein 10 (IP-10) and IL-5 were associated with a higher risk of AKI. EGF had an inverse correlation with kidney stress biomarkers. Subclinical AKI was characterized by a significant up-regulation of kidney stress biomarkers and proinflammatory cytokines. The lack of EGF regenerative effects and IFN-α antiviral activity seemed crucial for renal disease progression. AKI involved a proinflammatory urinary cytokine storm. |
| first_indexed | 2024-03-09T17:44:14Z |
| format | Article |
| id | doaj.art-1d952828b43f4ff3b8b39993b033b6b8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T17:44:14Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1d952828b43f4ff3b8b39993b033b6b82023-11-24T11:18:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123231541910.3390/ijms232315419Longitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney InjuryGustavo Casas-Aparicio0Claudia Alvarado-de la Barrera1David Escamilla-Illescas2Isabel León-Rodríguez3Perla Mariana Del Río-Estrada4Mauricio González-Navarro5Natalia Calderón-Dávila6Rossana Olmedo-Ocampo7Manuel Castillejos-López8Liliana Figueroa-Hernández9Amy B. Peralta-Prado10Yara Luna-Villalobos11Elvira Piten-Isidro12Paola Fernández-Campos13Alejandro Juárez-Díaz14Karolina Piekarska15Santiago Ávila-Ríos16Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoDirección de Medicina, Fundación Clínica Médica Sur. Puente de Piedra 29, Col. Toriello Guerra, Ciudad de Mexico 14040, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoDepartamento de Enseñanza, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoMédica Santa Carmen, Periférico Sur 5580, Local B, Col. El Caracol, Ciudad de Mexico 04739, MexicoUnidad de Epidemiología Hospitalaria e Infectología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoLaboratorio Clínico, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoDepartamento de Enseñanza, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoDepartamento de Enseñanza, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Col. Sección XVI, Ciudad de Mexico 14080, MexicoIn hospitalized COVID-19 patients, disease progression leading to acute kidney injury (AKI) may be driven by immune dysregulation. We explored the role of urinary cytokines and their relationship with kidney stress biomarkers in COVID-19 patients before and after the development of AKI. Of 51 patients, 54.9% developed AKI. The principal component analysis indicated that in subclinical AKI, epidermal growth factor (EGF) and interferon (IFN)-α were associated with a lower risk of AKI, while interleukin-12 (IL-12) and macrophage inflammatory protein (MIP)-1β were associated with a higher risk of AKI. After the manifestation of AKI, EGF and IFN-α remained associated with a lower risk of AKI, while IL-1 receptor (IL-1R), granulocyte-colony stimulating factor (G-CSF), interferon-gamma-inducible protein 10 (IP-10) and IL-5 were associated with a higher risk of AKI. EGF had an inverse correlation with kidney stress biomarkers. Subclinical AKI was characterized by a significant up-regulation of kidney stress biomarkers and proinflammatory cytokines. The lack of EGF regenerative effects and IFN-α antiviral activity seemed crucial for renal disease progression. AKI involved a proinflammatory urinary cytokine storm.https://www.mdpi.com/1422-0067/23/23/15419acute kidney injuryCOVID-19cytokinesepidermal growth factorneutrophil gelatinase-associated lipocalintissue inhibitor of metalloproteinases-2 |
| spellingShingle | Gustavo Casas-Aparicio Claudia Alvarado-de la Barrera David Escamilla-Illescas Isabel León-Rodríguez Perla Mariana Del Río-Estrada Mauricio González-Navarro Natalia Calderón-Dávila Rossana Olmedo-Ocampo Manuel Castillejos-López Liliana Figueroa-Hernández Amy B. Peralta-Prado Yara Luna-Villalobos Elvira Piten-Isidro Paola Fernández-Campos Alejandro Juárez-Díaz Karolina Piekarska Santiago Ávila-Ríos Longitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury International Journal of Molecular Sciences acute kidney injury COVID-19 cytokines epidermal growth factor neutrophil gelatinase-associated lipocalin tissue inhibitor of metalloproteinases-2 |
| title | Longitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury |
| title_full | Longitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury |
| title_fullStr | Longitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury |
| title_full_unstemmed | Longitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury |
| title_short | Longitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury |
| title_sort | longitudinal analysis of urinary cytokines and biomarkers in covid 19 patients with subclinical acute kidney injury |
| topic | acute kidney injury COVID-19 cytokines epidermal growth factor neutrophil gelatinase-associated lipocalin tissue inhibitor of metalloproteinases-2 |
| url | https://www.mdpi.com/1422-0067/23/23/15419 |
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