THE EVOLUTION OF UNDERSTANDING OF THE IMMUNE SYSTEM'S ROLE IN THE PATHOGENESIS OF INFLAMMATORY MYOCARDIAL DISEASES: TH17-MEDIATED IMMUNE MECHANISMS
The review article discusses recent advances in our understanding of viral myocarditis such as pathogenic role of infection and immune mechanisms in acute, sub-acute and chronic phases of the disease. A newly discovered Th17 lymphocyte subset and Interleukin 17 play an important role in the developm...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | Russian |
Published: |
Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2014-02-01
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Series: | Кубанский научный медицинский вестник |
Subjects: | |
Online Access: | https://ksma.elpub.ru/jour/article/view/52 |
Summary: | The review article discusses recent advances in our understanding of viral myocarditis such as pathogenic role of infection and immune mechanisms in acute, sub-acute and chronic phases of the disease. A newly discovered Th17 lymphocyte subset and Interleukin 17 play an important role in the development of inflammatory myocardial diseases. The protective effect of Interferon y and Th1 immune response in acute myocarditis and the role of Th17-mediated mechanisms in progression of acute myocarditis to dilated cardiomyopathy are considered. The evidence of pathogenic role of Th17 lymphocytes in viral myocarditis in human is given. |
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ISSN: | 1608-6228 2541-9544 |