Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review)
Background: Regular exercise is an effective non-pharmacological therapy for treatment and prevention of cardiovascular disease (CVD). The therapeutic benefits of exercise are mediated partly through improved vascular and increase in metabolic health. Release of exercise-responsive myokines, includi...
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.935772/full |
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| author | Shuguang Qin Shuguang Qin Zhenjun Tian Maxime Boidin Maxime Boidin Maxime Boidin Benjamin J. R. Buckley Benjamin J. R. Buckley Dick H. J. Thijssen Dick H. J. Thijssen Gregory Y. H. Lip Gregory Y. H. Lip |
| author_facet | Shuguang Qin Shuguang Qin Zhenjun Tian Maxime Boidin Maxime Boidin Maxime Boidin Benjamin J. R. Buckley Benjamin J. R. Buckley Dick H. J. Thijssen Dick H. J. Thijssen Gregory Y. H. Lip Gregory Y. H. Lip |
| author_sort | Shuguang Qin |
| collection | DOAJ |
| description | Background: Regular exercise is an effective non-pharmacological therapy for treatment and prevention of cardiovascular disease (CVD). The therapeutic benefits of exercise are mediated partly through improved vascular and increase in metabolic health. Release of exercise-responsive myokines, including irisin, is associated with beneficial effects of exercise in CVD patients.Observations: The present review provides an overview of the role of exercise in cardiac rehabilitation of patients with myocardial infarction (MI). Further, the role of irisin as a motion-responsive molecule in improving vascular and metabolic health is explored. Possible mechanism of cardioprotective effect of irisin-mediated exercise on myocardial infarction are also summarized in this review.Conclusion and significance of the review: Irisin is associated with reduced inflammation, antioxidant properties, and anti-apoptotic effect, implying that it is a potential key mediator of the beneficial effects of exercise on vascular and metabolic health. The findings show that irisin is a promising therapeutic target for treatment of patients with cardiovascular disease, particularly post-MI. Further research should be conducted to elucidate the potential mechanisms of cardioprotective effects of irisin and explored whether irisin induced by exercise exerts rehabilitation effects post-MI. |
| first_indexed | 2024-12-12T15:37:01Z |
| format | Article |
| id | doaj.art-1d96193d95414e55b5ba417012b27579 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T15:37:01Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-1d96193d95414e55b5ba417012b275792022-12-22T00:19:58ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-06-011310.3389/fphys.2022.935772935772Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review)Shuguang Qin0Shuguang Qin1Zhenjun Tian2Maxime Boidin3Maxime Boidin4Maxime Boidin5Benjamin J. R. Buckley6Benjamin J. R. Buckley7Dick H. J. Thijssen8Dick H. J. Thijssen9Gregory Y. H. Lip10Gregory Y. H. Lip11Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University, Xi’an, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University, Xi’an, ChinaLiverpool Centre for Cardiovascular Science, Liverpool John Moores University, Liverpool, United KingdomCardiovascular Prevention and Rehabilitation (EPIC) Center, Montreal Heart Institute, Montreal, QC, CanadaSchool of Kinesiology and Exercise Science, Faculty of Medicine, Université de Montréal, Montreal, QC, CanadaLiverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United KingdomCardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United KingdomLiverpool Centre for Cardiovascular Science, Liverpool John Moores University, Liverpool, United KingdomResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United KingdomLiverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United KingdomCardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United KingdomBackground: Regular exercise is an effective non-pharmacological therapy for treatment and prevention of cardiovascular disease (CVD). The therapeutic benefits of exercise are mediated partly through improved vascular and increase in metabolic health. Release of exercise-responsive myokines, including irisin, is associated with beneficial effects of exercise in CVD patients.Observations: The present review provides an overview of the role of exercise in cardiac rehabilitation of patients with myocardial infarction (MI). Further, the role of irisin as a motion-responsive molecule in improving vascular and metabolic health is explored. Possible mechanism of cardioprotective effect of irisin-mediated exercise on myocardial infarction are also summarized in this review.Conclusion and significance of the review: Irisin is associated with reduced inflammation, antioxidant properties, and anti-apoptotic effect, implying that it is a potential key mediator of the beneficial effects of exercise on vascular and metabolic health. The findings show that irisin is a promising therapeutic target for treatment of patients with cardiovascular disease, particularly post-MI. Further research should be conducted to elucidate the potential mechanisms of cardioprotective effects of irisin and explored whether irisin induced by exercise exerts rehabilitation effects post-MI.https://www.frontiersin.org/articles/10.3389/fphys.2022.935772/fullirisinexercisemyocardial infarctioncardiac rehabilitationcardioprotection |
| spellingShingle | Shuguang Qin Shuguang Qin Zhenjun Tian Maxime Boidin Maxime Boidin Maxime Boidin Benjamin J. R. Buckley Benjamin J. R. Buckley Dick H. J. Thijssen Dick H. J. Thijssen Gregory Y. H. Lip Gregory Y. H. Lip Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review) Frontiers in Physiology irisin exercise myocardial infarction cardiac rehabilitation cardioprotection |
| title | Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review) |
| title_full | Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review) |
| title_fullStr | Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review) |
| title_full_unstemmed | Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review) |
| title_short | Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review) |
| title_sort | irisin is an effector molecule in exercise rehabilitation following myocardial infarction review |
| topic | irisin exercise myocardial infarction cardiac rehabilitation cardioprotection |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.935772/full |
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