Terahertz refractive index-based morphological dilation for breast carcinoma delineation
Abstract This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-85853-8 |
| _version_ | 1818978356638515200 |
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| author | Quentin Cassar Samuel Caravera Gaëtan MacGrogan Thomas Bücher Philipp Hillger Ullrich Pfeiffer Thomas Zimmer Jean-Paul Guillet Patrick Mounaix |
| author_facet | Quentin Cassar Samuel Caravera Gaëtan MacGrogan Thomas Bücher Philipp Hillger Ullrich Pfeiffer Thomas Zimmer Jean-Paul Guillet Patrick Mounaix |
| author_sort | Quentin Cassar |
| collection | DOAJ |
| description | Abstract This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from an inverse electromagnetic problem. Morphological dilation combined with refractive index thresholding was conducted to classify the tissue regions as malignant or benign. A histology routine was conducted to evaluate the performances of various dilation geometries associated with different thresholds. It was found that the combination of a wide structuring element and high refractive index was improving the correctness of tissue classification in comparison to other configurations or without dilation. The method reports a sensitivity of around 80% and a specificity of 82% for the best case. These results indicate that combining the fundamental optical properties of tissues denoted by their refractive index with morphological dilation may open routes to define supporting procedures during breast-conserving surgeries. |
| first_indexed | 2024-12-20T16:42:20Z |
| format | Article |
| id | doaj.art-1d97acfa14124386a66fcdf46c0d6ffa |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T16:42:20Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1d97acfa14124386a66fcdf46c0d6ffa2022-12-21T19:33:00ZengNature PortfolioScientific Reports2045-23222021-03-0111111610.1038/s41598-021-85853-8Terahertz refractive index-based morphological dilation for breast carcinoma delineationQuentin Cassar0Samuel Caravera1Gaëtan MacGrogan2Thomas Bücher3Philipp Hillger4Ullrich Pfeiffer5Thomas Zimmer6Jean-Paul Guillet7Patrick Mounaix8Integration from Material to Systems Laboratory, University of BordeauxDepartment of Pathology, Bergonié InstituteDepartment of Pathology, Bergonié InstituteInstitute for High-Frequency and Communication Technology, University of WuppertalInstitute for High-Frequency and Communication Technology, University of WuppertalInstitute for High-Frequency and Communication Technology, University of WuppertalIntegration from Material to Systems Laboratory, University of BordeauxIntegration from Material to Systems Laboratory, University of BordeauxIntegration from Material to Systems Laboratory, University of BordeauxAbstract This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from an inverse electromagnetic problem. Morphological dilation combined with refractive index thresholding was conducted to classify the tissue regions as malignant or benign. A histology routine was conducted to evaluate the performances of various dilation geometries associated with different thresholds. It was found that the combination of a wide structuring element and high refractive index was improving the correctness of tissue classification in comparison to other configurations or without dilation. The method reports a sensitivity of around 80% and a specificity of 82% for the best case. These results indicate that combining the fundamental optical properties of tissues denoted by their refractive index with morphological dilation may open routes to define supporting procedures during breast-conserving surgeries.https://doi.org/10.1038/s41598-021-85853-8 |
| spellingShingle | Quentin Cassar Samuel Caravera Gaëtan MacGrogan Thomas Bücher Philipp Hillger Ullrich Pfeiffer Thomas Zimmer Jean-Paul Guillet Patrick Mounaix Terahertz refractive index-based morphological dilation for breast carcinoma delineation Scientific Reports |
| title | Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_full | Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_fullStr | Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_full_unstemmed | Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_short | Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_sort | terahertz refractive index based morphological dilation for breast carcinoma delineation |
| url | https://doi.org/10.1038/s41598-021-85853-8 |
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