Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion
Malathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and...
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MDPI AG
2022-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/3/350 |
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| author | Isam M. Abu Zeid Khalid M. Al-Asmari Hisham N. Altayb Atef M. Al-Attar Safa H. Qahl Mohammed Y. Alomar |
| author_facet | Isam M. Abu Zeid Khalid M. Al-Asmari Hisham N. Altayb Atef M. Al-Attar Safa H. Qahl Mohammed Y. Alomar |
| author_sort | Isam M. Abu Zeid |
| collection | DOAJ |
| description | Malathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and olive oils (400 mg/kg) for 7 weeks. Exposure to MAL resulted in statistically altered antioxidant enzymes and histopathological findings of necrotic seminiferous tubules and spermatogenetic arrest in rats after seven weeks of treatment. The effects of MAL intoxication on physiological and histopathological changes were improved by the use of these oils. Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively. Coffee oil and olive oil were found to be promising therapeutic agents for MAL-induced testicular toxicity and oxidative damage. |
| first_indexed | 2024-03-09T13:34:47Z |
| format | Article |
| id | doaj.art-1d98add5beab45e3ac40011a5787d0a0 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T13:34:47Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-1d98add5beab45e3ac40011a5787d0a02023-11-30T21:13:28ZengMDPI AGLife2075-17292022-02-0112335010.3390/life12030350Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by MalathionIsam M. Abu Zeid0Khalid M. Al-Asmari1Hisham N. Altayb2Atef M. Al-Attar3Safa H. Qahl4Mohammed Y. Alomar5Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Building A 90, Jeddah 21589, Saudi ArabiaDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Biology, College of Science, University of Jeddah, Jeddah 21959, Saudi ArabiaDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaMalathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and olive oils (400 mg/kg) for 7 weeks. Exposure to MAL resulted in statistically altered antioxidant enzymes and histopathological findings of necrotic seminiferous tubules and spermatogenetic arrest in rats after seven weeks of treatment. The effects of MAL intoxication on physiological and histopathological changes were improved by the use of these oils. Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively. Coffee oil and olive oil were found to be promising therapeutic agents for MAL-induced testicular toxicity and oxidative damage.https://www.mdpi.com/2075-1729/12/3/350malathionplant oiltesticularantioxidantin silico |
| spellingShingle | Isam M. Abu Zeid Khalid M. Al-Asmari Hisham N. Altayb Atef M. Al-Attar Safa H. Qahl Mohammed Y. Alomar Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion Life malathion plant oil testicular antioxidant in silico |
| title | Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion |
| title_full | Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion |
| title_fullStr | Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion |
| title_full_unstemmed | Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion |
| title_short | Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion |
| title_sort | predominance of antioxidants in some edible plant oils in ameliorating oxidative stress and testicular toxicity induced by malathion |
| topic | malathion plant oil testicular antioxidant in silico |
| url | https://www.mdpi.com/2075-1729/12/3/350 |
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