DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORS
ABSTRACT Background: Sarcopenia is a syndrome characterized by progressive and generalized loss of muscle mass and strength, observed to varying degrees in patients with various chronic conditions. In cirrhotic patients, it reflects protein-energy malnutrition due to metabolic protein imbalance and...
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
2023-11-01
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| Series: | Arquivos de Gastroenterologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032023000400431&lng=en&tlng=en |
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| author | Carolina Pretti Tumang de ANDRADE Lara Ferrari DALCUMUNE Núbia Mesquita FIORESE Livia Zardo TRINDADE Felipe Bertollo FERREIRA Mariana Poltronieri PACHECO |
| author_facet | Carolina Pretti Tumang de ANDRADE Lara Ferrari DALCUMUNE Núbia Mesquita FIORESE Livia Zardo TRINDADE Felipe Bertollo FERREIRA Mariana Poltronieri PACHECO |
| author_sort | Carolina Pretti Tumang de ANDRADE |
| collection | DOAJ |
| description | ABSTRACT Background: Sarcopenia is a syndrome characterized by progressive and generalized loss of muscle mass and strength, observed to varying degrees in patients with various chronic conditions. In cirrhotic patients, it reflects protein-energy malnutrition due to metabolic protein imbalance and is associated with worsened prognosis and reduced post-liver transplantation survival. Objective: To evaluate the epidemiological distribution of diminished hand grip (HG) strength in cirrhotic patients at an outpatient clinic of Santa Casa de Misericórdia in Vitória-ES, Brazil, seeking its association with liver function and cirrhosis complications. Methods: Cross-sectional, epidemiological, and single-center study. A questionnaire was administered to patients and HG strength was measured using a dynamometer, with three interval measures taken for 3 seconds each. Results: The study’s total population was 64 cirrhotic patients, with a mean age of 58 years and alcohol as the most prevalent etiology. Reduced HG strength was defined based on two reference values: using cutoff point 1, reduced HG strength was identified in 33 patients (51.6%); according to cutoff point 2, 23 (35.9%) had reduced HG strength. The study showed that, among the parameters observed, there was an association between the female gender and diminished HG strength in both cutoff points. Additionally, it was noted that patients with a score of 15 or more on the Model for End-Stage Liver Disease (MELD) had decreased HG strength at cutoff point 2. The study showed no association between decreased HG strength and the occurrence of cirrhosis complications in the population studied. Conclusion: In our study, we obtained a diminished HG strength variation of 35-52%, which was related to higher MELD scores, suggesting an association with worse clinical outcomes. Therefore, the presence of reduced muscle strength in cirrhotic patients may be linked to prognostic factors and should be valued as clinical data in the management of these patients. |
| first_indexed | 2024-03-09T14:24:08Z |
| format | Article |
| id | doaj.art-1d98fb1ac9ae410fb871a837a710129b |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-03-09T14:24:08Z |
| publishDate | 2023-11-01 |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-1d98fb1ac9ae410fb871a837a710129b2023-11-28T07:48:39ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-42192023-11-0160443143710.1590/s0004-2803.230402023-69DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORSCarolina Pretti Tumang de ANDRADEhttps://orcid.org/0009-0001-2100-2588Lara Ferrari DALCUMUNEhttps://orcid.org/0009-0000-9117-6201Núbia Mesquita FIORESEhttps://orcid.org/0009-0004-6408-6146Livia Zardo TRINDADEhttps://orcid.org/0000-0003-3671-2299Felipe Bertollo FERREIRAhttps://orcid.org/0000-0003-1334-2600Mariana Poltronieri PACHECOhttps://orcid.org/0000-0002-3932-3195ABSTRACT Background: Sarcopenia is a syndrome characterized by progressive and generalized loss of muscle mass and strength, observed to varying degrees in patients with various chronic conditions. In cirrhotic patients, it reflects protein-energy malnutrition due to metabolic protein imbalance and is associated with worsened prognosis and reduced post-liver transplantation survival. Objective: To evaluate the epidemiological distribution of diminished hand grip (HG) strength in cirrhotic patients at an outpatient clinic of Santa Casa de Misericórdia in Vitória-ES, Brazil, seeking its association with liver function and cirrhosis complications. Methods: Cross-sectional, epidemiological, and single-center study. A questionnaire was administered to patients and HG strength was measured using a dynamometer, with three interval measures taken for 3 seconds each. Results: The study’s total population was 64 cirrhotic patients, with a mean age of 58 years and alcohol as the most prevalent etiology. Reduced HG strength was defined based on two reference values: using cutoff point 1, reduced HG strength was identified in 33 patients (51.6%); according to cutoff point 2, 23 (35.9%) had reduced HG strength. The study showed that, among the parameters observed, there was an association between the female gender and diminished HG strength in both cutoff points. Additionally, it was noted that patients with a score of 15 or more on the Model for End-Stage Liver Disease (MELD) had decreased HG strength at cutoff point 2. The study showed no association between decreased HG strength and the occurrence of cirrhosis complications in the population studied. Conclusion: In our study, we obtained a diminished HG strength variation of 35-52%, which was related to higher MELD scores, suggesting an association with worse clinical outcomes. Therefore, the presence of reduced muscle strength in cirrhotic patients may be linked to prognostic factors and should be valued as clinical data in the management of these patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032023000400431&lng=en&tlng=enCirrhosissarcopeniaprognosis |
| spellingShingle | Carolina Pretti Tumang de ANDRADE Lara Ferrari DALCUMUNE Núbia Mesquita FIORESE Livia Zardo TRINDADE Felipe Bertollo FERREIRA Mariana Poltronieri PACHECO DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORS Arquivos de Gastroenterologia Cirrhosis sarcopenia prognosis |
| title | DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORS |
| title_full | DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORS |
| title_fullStr | DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORS |
| title_full_unstemmed | DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORS |
| title_short | DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORS |
| title_sort | diminished hand grip strength and cirrhosis prevalence and associated factors |
| topic | Cirrhosis sarcopenia prognosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032023000400431&lng=en&tlng=en |
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