Cointegration as a mechanism for the evolution of a KPC-producing multidrug resistance plasmid in Proteus mirabilis

Cointegration as a mechanism for the evolution of a KPC-producing multidrug resistance plasmid in Proteus mirabilis

ABSTRACTThe incidence and transmission of Klebsiella pneumoniae carbapenemase (KPC) producing plasmids have been well documented. However, the evolutionary dynamics of KPC plasmids and their fitness costs are not well characterized. Here, two carbapenemase-producing plasmids from Proteus mirabilis,...

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Bibliographic Details
Main Authors: Xiaoting Hua, Linyue Zhang, Robert A. Moran, Qingye Xu, Long Sun, Willem van Schaik, Yunsong Yu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
Proteus mirabilis
plasmids
evolution
blaKPC-2
IS26
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1773322

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