Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injury
Traumatic brain injury (TBI) can result in persistent cognitive, behavioral and emotional deficits. However, the vast majority of patients are not chronically hospitalized; rather they have to manage their disabilities once they are discharged to home. Promoting recovery to pre-injury level is imp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2016.00030/full |
| _version_ | 1819046488217485312 |
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| author | Aleksandr ePevzner Aleksandr ePevzner Ali eIzadi Ali eIzadi Darrin Jason Lee Darrin Jason Lee Kiarash eShahlaie Kiarash eShahlaie Gene eGurkoff Gene eGurkoff |
| author_facet | Aleksandr ePevzner Aleksandr ePevzner Ali eIzadi Ali eIzadi Darrin Jason Lee Darrin Jason Lee Kiarash eShahlaie Kiarash eShahlaie Gene eGurkoff Gene eGurkoff |
| author_sort | Aleksandr ePevzner |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) can result in persistent cognitive, behavioral and emotional deficits. However, the vast majority of patients are not chronically hospitalized; rather they have to manage their disabilities once they are discharged to home. Promoting recovery to pre-injury level is important from a patient care as well as a societal perspective. Electrical neuromodulation is one approach that has shown promise in alleviating symptoms associated with neurological disorders such as in Parkinson’s disease and epilepsy. Consistent with this perspective, both animal and clinical studies have revealed that TBI alters physiological oscillatory rhythms. More recently several studies demonstrated that low frequency stimulation improves cognitive outcome in models of TBI. Specifically, stimulation of the septohippocampal circuit in the theta frequency entrained oscillations and improved spatial learning following traumatic brain injury. In order to evaluate the potential of electrical deep brain stimulation for clinical translation we review the basic neurophysiology of oscillations, their role in cognition and how they are changed post-TBI. Furthermore, we highlight several factors for future pre-clinical and clinical studies to consider, with the hope that it will promote a hypothesis driven approach to subsequent experimental designs and ultimately successful translation to improve outcome in patients with TBI. |
| first_indexed | 2024-12-21T10:45:16Z |
| format | Article |
| id | doaj.art-1d9c6947e6694e61aab1da6e1101de67 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-21T10:45:16Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-1d9c6947e6694e61aab1da6e1101de672022-12-21T19:06:49ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372016-04-011010.3389/fnsys.2016.00030188028Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injuryAleksandr ePevzner0Aleksandr ePevzner1Ali eIzadi2Ali eIzadi3Darrin Jason Lee4Darrin Jason Lee5Kiarash eShahlaie6Kiarash eShahlaie7Gene eGurkoff8Gene eGurkoff9University of California- DavisUniversity of California- DavisUniversity of California- DavisUniversity of California- DavisUniversity of California- DavisUniversity of California- DavisUniversity of California- DavisUniversity of California- DavisUniversity of California- DavisUniversity of California- DavisTraumatic brain injury (TBI) can result in persistent cognitive, behavioral and emotional deficits. However, the vast majority of patients are not chronically hospitalized; rather they have to manage their disabilities once they are discharged to home. Promoting recovery to pre-injury level is important from a patient care as well as a societal perspective. Electrical neuromodulation is one approach that has shown promise in alleviating symptoms associated with neurological disorders such as in Parkinson’s disease and epilepsy. Consistent with this perspective, both animal and clinical studies have revealed that TBI alters physiological oscillatory rhythms. More recently several studies demonstrated that low frequency stimulation improves cognitive outcome in models of TBI. Specifically, stimulation of the septohippocampal circuit in the theta frequency entrained oscillations and improved spatial learning following traumatic brain injury. In order to evaluate the potential of electrical deep brain stimulation for clinical translation we review the basic neurophysiology of oscillations, their role in cognition and how they are changed post-TBI. Furthermore, we highlight several factors for future pre-clinical and clinical studies to consider, with the hope that it will promote a hypothesis driven approach to subsequent experimental designs and ultimately successful translation to improve outcome in patients with TBI.http://journal.frontiersin.org/Journal/10.3389/fnsys.2016.00030/fullHippocampusTheta Rhythmoscillationsdeep brain stimulation (DBS)Traumatic brain injury (TBI)Electrical neural stimulation |
| spellingShingle | Aleksandr ePevzner Aleksandr ePevzner Ali eIzadi Ali eIzadi Darrin Jason Lee Darrin Jason Lee Kiarash eShahlaie Kiarash eShahlaie Gene eGurkoff Gene eGurkoff Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injury Frontiers in Systems Neuroscience Hippocampus Theta Rhythm oscillations deep brain stimulation (DBS) Traumatic brain injury (TBI) Electrical neural stimulation |
| title | Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injury |
| title_full | Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injury |
| title_fullStr | Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injury |
| title_full_unstemmed | Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injury |
| title_short | Making waves in the brain: What are oscillations, and why modulating them makes sense for brain injury |
| title_sort | making waves in the brain what are oscillations and why modulating them makes sense for brain injury |
| topic | Hippocampus Theta Rhythm oscillations deep brain stimulation (DBS) Traumatic brain injury (TBI) Electrical neural stimulation |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2016.00030/full |
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