Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities
Melanoma is the deadliest form of skin cancer and remains a diagnostic challenge in the dermatology clinic. Several non-invasive imaging techniques have been developed to identify melanoma. The signal source in each of these modalities is based on the alteration of physical characteristics of the ti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9583 |
| _version_ | 1797544523568513024 |
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| author | Monica Hessler Elmira Jalilian Qiuyun Xu Shriya Reddy Luke Horton Kenneth Elkin Rayyan Manwar Maria Tsoukas Darius Mehregan Kamran Avanaki |
| author_facet | Monica Hessler Elmira Jalilian Qiuyun Xu Shriya Reddy Luke Horton Kenneth Elkin Rayyan Manwar Maria Tsoukas Darius Mehregan Kamran Avanaki |
| author_sort | Monica Hessler |
| collection | DOAJ |
| description | Melanoma is the deadliest form of skin cancer and remains a diagnostic challenge in the dermatology clinic. Several non-invasive imaging techniques have been developed to identify melanoma. The signal source in each of these modalities is based on the alteration of physical characteristics of the tissue from healthy/benign to melanoma. However, as these characteristics are not always sufficiently specific, the current imaging techniques are not adequate for use in the clinical setting. A more robust way of melanoma diagnosis is to “stain” or selectively target the suspect tissue with a melanoma biomarker attached to a contrast enhancer of one imaging modality. Here, we categorize and review known melanoma diagnostic biomarkers with the goal of guiding skin imaging experts to design an appropriate diagnostic tool for differentiating between melanoma and benign lesions with a high specificity and sensitivity. |
| first_indexed | 2024-03-10T14:01:45Z |
| format | Article |
| id | doaj.art-1d9dc9c58bba43f48f9ff45cb50bbcca |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:01:45Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1d9dc9c58bba43f48f9ff45cb50bbcca2023-11-21T01:01:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124958310.3390/ijms21249583Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging ModalitiesMonica Hessler0Elmira Jalilian1Qiuyun Xu2Shriya Reddy3Luke Horton4Kenneth Elkin5Rayyan Manwar6Maria Tsoukas7Darius Mehregan8Kamran Avanaki9Department of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USADepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60607, USADepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USADepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USADepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USADepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USADepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USADepartment of Dermatology, University of Illinois at Chicago, Chicago, IL 60607, USADepartment of Dermatology, School of Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USARichard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USAMelanoma is the deadliest form of skin cancer and remains a diagnostic challenge in the dermatology clinic. Several non-invasive imaging techniques have been developed to identify melanoma. The signal source in each of these modalities is based on the alteration of physical characteristics of the tissue from healthy/benign to melanoma. However, as these characteristics are not always sufficiently specific, the current imaging techniques are not adequate for use in the clinical setting. A more robust way of melanoma diagnosis is to “stain” or selectively target the suspect tissue with a melanoma biomarker attached to a contrast enhancer of one imaging modality. Here, we categorize and review known melanoma diagnostic biomarkers with the goal of guiding skin imaging experts to design an appropriate diagnostic tool for differentiating between melanoma and benign lesions with a high specificity and sensitivity.https://www.mdpi.com/1422-0067/21/24/9583melanomabiomarkersskin cancerbenign nevinon-invasive |
| spellingShingle | Monica Hessler Elmira Jalilian Qiuyun Xu Shriya Reddy Luke Horton Kenneth Elkin Rayyan Manwar Maria Tsoukas Darius Mehregan Kamran Avanaki Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities International Journal of Molecular Sciences melanoma biomarkers skin cancer benign nevi non-invasive |
| title | Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities |
| title_full | Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities |
| title_fullStr | Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities |
| title_full_unstemmed | Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities |
| title_short | Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities |
| title_sort | melanoma biomarkers and their potential application for in vivo diagnostic imaging modalities |
| topic | melanoma biomarkers skin cancer benign nevi non-invasive |
| url | https://www.mdpi.com/1422-0067/21/24/9583 |
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