Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/12/5/588 |
| _version_ | 1797501155372171264 |
|---|---|
| author | María Flores-López Nuria García-Marchena Pedro Araos Nerea Requena-Ocaña Oscar Porras-Perales Sandra Torres-Galván Juan Suarez Nieves Pizarro Rafael de la Torre Gabriel Rubio Juan Jesús Ruiz-Ruiz Fernando Rodríguez de Fonseca Antonia Serrano Francisco Javier Pavón-Morón |
| author_facet | María Flores-López Nuria García-Marchena Pedro Araos Nerea Requena-Ocaña Oscar Porras-Perales Sandra Torres-Galván Juan Suarez Nieves Pizarro Rafael de la Torre Gabriel Rubio Juan Jesús Ruiz-Ruiz Fernando Rodríguez de Fonseca Antonia Serrano Francisco Javier Pavón-Morón |
| author_sort | María Flores-López |
| collection | DOAJ |
| description | Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs. |
| first_indexed | 2024-03-10T03:14:17Z |
| format | Article |
| id | doaj.art-1d9eb65ad6f34b30851d45e530c2756d |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:17Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-1d9eb65ad6f34b30851d45e530c2756d2023-11-23T10:17:32ZengMDPI AGBrain Sciences2076-34252022-04-0112558810.3390/brainsci12050588Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use DisordersMaría Flores-López0Nuria García-Marchena1Pedro Araos2Nerea Requena-Ocaña3Oscar Porras-Perales4Sandra Torres-Galván5Juan Suarez6Nieves Pizarro7Rafael de la Torre8Gabriel Rubio9Juan Jesús Ruiz-Ruiz10Fernando Rodríguez de Fonseca11Antonia Serrano12Francisco Javier Pavón-Morón13Instituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainGrup de Recerca en Farmacologia Integrada i Neurociència de Sistemes, Programa de Recerca en Neurociéncia, Institut Hospital del Mar d’Investigacions Mèdiques-IMIM, 08003 Barcelona, SpainGrup de Recerca en Farmacologia Integrada i Neurociència de Sistemes, Programa de Recerca en Neurociéncia, Institut Hospital del Mar d’Investigacions Mèdiques-IMIM, 08003 Barcelona, SpainServicio de Psiquiatría, Hospital Universitario 12 de Octubre, 28041 Madrid, SpainCentro Provincial de Drogodependencias de Málaga, Diputación Provincial de Málaga, 29010 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga—IBIMA, 29590 Málaga, SpainPreclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.https://www.mdpi.com/2076-3425/12/5/588lysophosphatidic acidbiomarkersexsubstance use disorderalcoholcocaine |
| spellingShingle | María Flores-López Nuria García-Marchena Pedro Araos Nerea Requena-Ocaña Oscar Porras-Perales Sandra Torres-Galván Juan Suarez Nieves Pizarro Rafael de la Torre Gabriel Rubio Juan Jesús Ruiz-Ruiz Fernando Rodríguez de Fonseca Antonia Serrano Francisco Javier Pavón-Morón Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders Brain Sciences lysophosphatidic acid biomarker sex substance use disorder alcohol cocaine |
| title | Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders |
| title_full | Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders |
| title_fullStr | Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders |
| title_full_unstemmed | Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders |
| title_short | Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders |
| title_sort | sex differences in plasma lysophosphatidic acid species in patients with alcohol and cocaine use disorders |
| topic | lysophosphatidic acid biomarker sex substance use disorder alcohol cocaine |
| url | https://www.mdpi.com/2076-3425/12/5/588 |
| work_keys_str_mv | AT mariafloreslopez sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT nuriagarciamarchena sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT pedroaraos sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT nerearequenaocana sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT oscarporrasperales sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT sandratorresgalvan sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT juansuarez sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT nievespizarro sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT rafaeldelatorre sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT gabrielrubio sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT juanjesusruizruiz sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT fernandorodriguezdefonseca sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT antoniaserrano sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders AT franciscojavierpavonmoron sexdifferencesinplasmalysophosphatidicacidspeciesinpatientswithalcoholandcocaineusedisorders |