Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema

Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema

Abstract Background High-altitude cerebral edema (HACE) is a serious and potentially fatal brain injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the main pathological factor of this condition. Hypoxia-induced disruptions of tight junctions in the endothelium trigge...

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Bibliographic Details
Main Authors: Yan Xue, Xueting Wang, Baolan Wan, Dongzhi Wang, Meiqi Li, Kang Cheng, Qianqian Luo, Dan Wang, Yapeng Lu, Li Zhu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cell Communication and Signaling
Subjects:
High-altitude cerebral edema
Caveolin-1
Blood‒brain barrier
Endothelium
Claudin-5
Online Access:https://doi.org/10.1186/s12964-022-00976-3

Internet

https://doi.org/10.1186/s12964-022-00976-3

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