Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease
Astrocytes are the most abundant glia in the central nervous system that play a significant role in disease. Recently, it roles of synaptic plasticity in neuropathological damages have been questioned whether the structural and functional plasticity of synapses contributes to the pathogenesis of...
| Huvudupphovsmän: | , |
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| Materialtyp: | Artikel |
| Språk: | English |
| Publicerad: |
IMR Press
2021-06-01
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| Serie: | Journal of Integrative Neuroscience |
| Ämnen: | |
| Länkar: | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014748470-583048528.pdf |
| _version_ | 1828490684057780224 |
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| author | Yuqi Zhang Kangrong Lu |
| author_facet | Yuqi Zhang Kangrong Lu |
| author_sort | Yuqi Zhang |
| collection | DOAJ |
| description | Astrocytes are the most abundant glia in the
central nervous system that play a significant role in disease. Recently, it
roles of synaptic plasticity in neuropathological damages have been questioned
whether the structural and functional plasticity of synapses contributes to the
pathogenesis of Parkinson’s disease. The regulation of synaptic plasticity by
astrocytes has also been widely researched based on astrocytes regulate synaptic
plasticity by releasing Adenosine triphosphate, glutamate, and D-serine. We
discuss the possible role of astrocytes in the regulation of synaptic plasticity,
which may provide a new direction to Parkinson’s disease treatment. |
| first_indexed | 2024-12-11T10:49:02Z |
| format | Article |
| id | doaj.art-1da46aadf3924d0f8e8082f23b7b2ffe |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-12-11T10:49:02Z |
| publishDate | 2021-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-1da46aadf3924d0f8e8082f23b7b2ffe2022-12-22T01:10:24ZengIMR PressJournal of Integrative Neuroscience1757-448X2021-06-0120251552510.31083/j.jin20020551625014748470-583048528Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s diseaseYuqi Zhang0Kangrong Lu12017 Clinical Excellence and Innovation Class of the Second Clinical Medical College of Southern Medical University, 510515 Guangzhou, Guangdong Province, ChinaDepartment of Histology and Embryology, School of Basic Sciences, Southern Medical University, 510515 Guangzhou, Guangdong Province, ChinaAstrocytes are the most abundant glia in the central nervous system that play a significant role in disease. Recently, it roles of synaptic plasticity in neuropathological damages have been questioned whether the structural and functional plasticity of synapses contributes to the pathogenesis of Parkinson’s disease. The regulation of synaptic plasticity by astrocytes has also been widely researched based on astrocytes regulate synaptic plasticity by releasing Adenosine triphosphate, glutamate, and D-serine. We discuss the possible role of astrocytes in the regulation of synaptic plasticity, which may provide a new direction to Parkinson’s disease treatment.https://jin.imrpress.com/fileup/1757-448X/PDF/1625014748470-583048528.pdfparkinson's disease (pd)astrocytesynaptic plasticity |
| spellingShingle | Yuqi Zhang Kangrong Lu Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease Journal of Integrative Neuroscience parkinson's disease (pd) astrocyte synaptic plasticity |
| title | Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease |
| title_full | Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease |
| title_fullStr | Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease |
| title_full_unstemmed | Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease |
| title_short | Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease |
| title_sort | potential protective role of astrocytes in the pathogenesis of astrocyte mediated synaptic plasticity of parkinson s disease |
| topic | parkinson's disease (pd) astrocyte synaptic plasticity |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014748470-583048528.pdf |
| work_keys_str_mv | AT yuqizhang potentialprotectiveroleofastrocytesinthepathogenesisofastrocytemediatedsynapticplasticityofparkinsonsdisease AT kangronglu potentialprotectiveroleofastrocytesinthepathogenesisofastrocytemediatedsynapticplasticityofparkinsonsdisease |