TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells
Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic cancer goblet cell line (HT29-18N2) revealed new proteins, including a Ca2+-activ...
Main Authors: | Sandra Mitrovic, Cristina Nogueira, Gerard Cantero-Recasens, Kerstin Kiefer, José M Fernández-Fernández, Jean-François Popoff, Laetitia Casano, Frederic A Bard, Raul Gomez, Miguel A Valverde, Vivek Malhotra |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/00658 |
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