CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIS
Suture material has significant influence on remote results of surgical intervention, and in particular, in reconstructive operations on heart and vessels. Despite the great choice of suture material in the market, there are no threads with directed antithrombotic effect. With the purpose of increas...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kemerovo State University
2014-11-01
|
| Series: | Вестник Кемеровского государственного университета |
| Subjects: | |
| Online Access: | https://vestnik.kemsu.ru/jour/article/view/1033 |
| _version_ | 1797781306791165952 |
|---|---|
| author | T. N. Akentyeva S. V. Luzgarev T. V. Glushkova Yu. A. Kudryavtseva |
| author_facet | T. N. Akentyeva S. V. Luzgarev T. V. Glushkova Yu. A. Kudryavtseva |
| author_sort | T. N. Akentyeva |
| collection | DOAJ |
| description | Suture material has significant influence on remote results of surgical intervention, and in particular, in reconstructive operations on heart and vessels. Despite the great choice of suture material in the market, there are no threads with directed antithrombotic effect. With the purpose of increasing thromboresistant properties of suture material, the most promising method is the application of biodegradable coating based on polyhydroxyalkanoate biopolymer and nonfractionated heparin by the method of chemical grafting. Antithrombotic coating of polypropylene thread is achieved through the creation of reactive intermediate layer. The study of grafting of heparin onto substrate by the methods of diffuse reflectance infrared spectroscopy and scanning electron microscopy showed uniform location and strong holding of heparin on the surface of the thread. |
| first_indexed | 2024-03-12T23:55:48Z |
| format | Article |
| id | doaj.art-1da63e6691564dcdb530cd82091cad5c |
| institution | Directory Open Access Journal |
| issn | 2078-8975 2078-8983 |
| language | English |
| last_indexed | 2024-03-12T23:55:48Z |
| publishDate | 2014-11-01 |
| publisher | Kemerovo State University |
| record_format | Article |
| series | Вестник Кемеровского государственного университета |
| spelling | doaj.art-1da63e6691564dcdb530cd82091cad5c2023-07-13T12:08:37ZengKemerovo State UniversityВестник Кемеровского государственного университета2078-89752078-89832014-11-0104-32282321032CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIST. N. Akentyeva0S. V. Luzgarev1T. V. Glushkova2Yu. A. Kudryavtseva3Research Institute for Complex Issues of Cardiovascular DiseaseKemerovo State UniversityInstitute for Complex Issues of Cardiovascular DiseaseInstitute for Complex Issues of Cardiovascular DiseaseSuture material has significant influence on remote results of surgical intervention, and in particular, in reconstructive operations on heart and vessels. Despite the great choice of suture material in the market, there are no threads with directed antithrombotic effect. With the purpose of increasing thromboresistant properties of suture material, the most promising method is the application of biodegradable coating based on polyhydroxyalkanoate biopolymer and nonfractionated heparin by the method of chemical grafting. Antithrombotic coating of polypropylene thread is achieved through the creation of reactive intermediate layer. The study of grafting of heparin onto substrate by the methods of diffuse reflectance infrared spectroscopy and scanning electron microscopy showed uniform location and strong holding of heparin on the surface of the thread.https://vestnik.kemsu.ru/jour/article/view/1033suture materialthrombosisantithrombotic coatingchemical graftingpolymerheparin |
| spellingShingle | T. N. Akentyeva S. V. Luzgarev T. V. Glushkova Yu. A. Kudryavtseva CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIS Вестник Кемеровского государственного университета suture material thrombosis antithrombotic coating chemical grafting polymer heparin |
| title | CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIS |
| title_full | CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIS |
| title_fullStr | CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIS |
| title_full_unstemmed | CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIS |
| title_short | CHEMICAL MODIFICATION OF SURGICAL SUTURE MATERIAL TO PREVENT ARTERIAL THROMBOSIS |
| title_sort | chemical modification of surgical suture material to prevent arterial thrombosis |
| topic | suture material thrombosis antithrombotic coating chemical grafting polymer heparin |
| url | https://vestnik.kemsu.ru/jour/article/view/1033 |
| work_keys_str_mv | AT tnakentyeva chemicalmodificationofsurgicalsuturematerialtopreventarterialthrombosis AT svluzgarev chemicalmodificationofsurgicalsuturematerialtopreventarterialthrombosis AT tvglushkova chemicalmodificationofsurgicalsuturematerialtopreventarterialthrombosis AT yuakudryavtseva chemicalmodificationofsurgicalsuturematerialtopreventarterialthrombosis |