Nanocarrier from water extract solution of Auricularia auricula for zinc delivery
Food-borne nanoparticles (FNs) may have potential for microelement delivery due to their good biocompatibility and healthy benefits. In this paper, hydrophilic FNs with ultra-small size of 1.7 nm were prepared from the water extract solution of Auricularia auricula by hydrothermal method. The struct...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Food Hydrocolloids for Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667025922000176 |
| _version_ | 1811315568976855040 |
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| author | Xiaoting Yu Yannan Chen Shanghua Xing Deyang Yu Mingqian Tan |
| author_facet | Xiaoting Yu Yannan Chen Shanghua Xing Deyang Yu Mingqian Tan |
| author_sort | Xiaoting Yu |
| collection | DOAJ |
| description | Food-borne nanoparticles (FNs) may have potential for microelement delivery due to their good biocompatibility and healthy benefits. In this paper, hydrophilic FNs with ultra-small size of 1.7 nm were prepared from the water extract solution of Auricularia auricula by hydrothermal method. The structural characterization showed that Zn(II)-FNs were formed after the interaction of abundant functional groups like amino, hydroxyl, and carboxyl functional groups on the surface of FNs with Zn2+. The Zn(II)-FNs showed better cell compatibility than ZnSO4 and zinc gluconate with no visible cytotoxicity at concentrations up to 75 μg/mL for the normal rat kidney cells. Less than 5% hemolysis rate was found when the concentration of Zn(II)-FNs was 5 mg/mL after incubation for 3h. The biodistribution experiments indicated that Zn(II)-FNs had no obvious toxic effect after being orally administrated at a dose of 500 mg/kg mouse body weight, and Zn(II)-FNs were present in the stomach, intestine, lung, liver, and kidney. Our data indicated that FNs collected from Auricularia auricula water extract solution might act as a safe and effective nanocarrier for Zn(II). |
| first_indexed | 2024-04-13T11:32:40Z |
| format | Article |
| id | doaj.art-1da6f6f18f06448d813784253070dc95 |
| institution | Directory Open Access Journal |
| issn | 2667-0259 |
| language | English |
| last_indexed | 2024-04-13T11:32:40Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Hydrocolloids for Health |
| spelling | doaj.art-1da6f6f18f06448d813784253070dc952022-12-22T02:48:31ZengElsevierFood Hydrocolloids for Health2667-02592022-12-012100070Nanocarrier from water extract solution of Auricularia auricula for zinc deliveryXiaoting Yu0Yannan Chen1Shanghua Xing2Deyang Yu3Mingqian Tan4Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of China; National Engineering Research Center of Seafood, Dalian 116034, Liaoning, People's Republic of China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of China; National Engineering Research Center of Seafood, Dalian 116034, Liaoning, People's Republic of China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of China; National Engineering Research Center of Seafood, Dalian 116034, Liaoning, People's Republic of China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of China; National Engineering Research Center of Seafood, Dalian 116034, Liaoning, People's Republic of China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of China; National Engineering Research Center of Seafood, Dalian 116034, Liaoning, People's Republic of China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, People's Republic of China; Corresponding author. Qinggongyuan 1, Ganjingzi District, Dalian 116034, Liaoning, People's Republic of China.Food-borne nanoparticles (FNs) may have potential for microelement delivery due to their good biocompatibility and healthy benefits. In this paper, hydrophilic FNs with ultra-small size of 1.7 nm were prepared from the water extract solution of Auricularia auricula by hydrothermal method. The structural characterization showed that Zn(II)-FNs were formed after the interaction of abundant functional groups like amino, hydroxyl, and carboxyl functional groups on the surface of FNs with Zn2+. The Zn(II)-FNs showed better cell compatibility than ZnSO4 and zinc gluconate with no visible cytotoxicity at concentrations up to 75 μg/mL for the normal rat kidney cells. Less than 5% hemolysis rate was found when the concentration of Zn(II)-FNs was 5 mg/mL after incubation for 3h. The biodistribution experiments indicated that Zn(II)-FNs had no obvious toxic effect after being orally administrated at a dose of 500 mg/kg mouse body weight, and Zn(II)-FNs were present in the stomach, intestine, lung, liver, and kidney. Our data indicated that FNs collected from Auricularia auricula water extract solution might act as a safe and effective nanocarrier for Zn(II).http://www.sciencedirect.com/science/article/pii/S2667025922000176Auricularia auriculaFood-borne nanoparticlesNanocarrierZinc deliveryBiocompatibilityBiodistribution |
| spellingShingle | Xiaoting Yu Yannan Chen Shanghua Xing Deyang Yu Mingqian Tan Nanocarrier from water extract solution of Auricularia auricula for zinc delivery Food Hydrocolloids for Health Auricularia auricula Food-borne nanoparticles Nanocarrier Zinc delivery Biocompatibility Biodistribution |
| title | Nanocarrier from water extract solution of Auricularia auricula for zinc delivery |
| title_full | Nanocarrier from water extract solution of Auricularia auricula for zinc delivery |
| title_fullStr | Nanocarrier from water extract solution of Auricularia auricula for zinc delivery |
| title_full_unstemmed | Nanocarrier from water extract solution of Auricularia auricula for zinc delivery |
| title_short | Nanocarrier from water extract solution of Auricularia auricula for zinc delivery |
| title_sort | nanocarrier from water extract solution of auricularia auricula for zinc delivery |
| topic | Auricularia auricula Food-borne nanoparticles Nanocarrier Zinc delivery Biocompatibility Biodistribution |
| url | http://www.sciencedirect.com/science/article/pii/S2667025922000176 |
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