Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension
Hyperproliferation of pulmonary arterial smooth muscle cells is a key component of vascular remodeling in the setting of pulmonary hypertension (PH). Numerous studies have explored factors governing the changes in smooth muscle cell phenotype that lead to the increased wall thickness, and have ident...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3921/8/3/56 |
| _version_ | 1797711630196277248 |
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| author | John C. Huetsch Karthik Suresh Larissa A. Shimoda |
| author_facet | John C. Huetsch Karthik Suresh Larissa A. Shimoda |
| author_sort | John C. Huetsch |
| collection | DOAJ |
| description | Hyperproliferation of pulmonary arterial smooth muscle cells is a key component of vascular remodeling in the setting of pulmonary hypertension (PH). Numerous studies have explored factors governing the changes in smooth muscle cell phenotype that lead to the increased wall thickness, and have identified various potential candidates. A role for reactive oxygen species (ROS) has been well documented in PH. ROS can be generated from a variety of sources, including mitochondria, uncoupled nitric oxide synthase, xanthine oxidase, and reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. In this article, we will review recent data supporting a role for ROS generated from NADPH oxidases in promoting pulmonary arterial smooth muscle cell proliferation during PH. |
| first_indexed | 2024-03-12T07:09:53Z |
| format | Article |
| id | doaj.art-1da8e5fe43ef418b9fea7685e2a437e4 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T07:09:53Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1da8e5fe43ef418b9fea7685e2a437e42023-09-02T23:08:50ZengMDPI AGAntioxidants2076-39212019-03-01835610.3390/antiox8030056antiox8030056Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary HypertensionJohn C. Huetsch0Karthik Suresh1Larissa A. Shimoda2Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USADepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USADepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USAHyperproliferation of pulmonary arterial smooth muscle cells is a key component of vascular remodeling in the setting of pulmonary hypertension (PH). Numerous studies have explored factors governing the changes in smooth muscle cell phenotype that lead to the increased wall thickness, and have identified various potential candidates. A role for reactive oxygen species (ROS) has been well documented in PH. ROS can be generated from a variety of sources, including mitochondria, uncoupled nitric oxide synthase, xanthine oxidase, and reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. In this article, we will review recent data supporting a role for ROS generated from NADPH oxidases in promoting pulmonary arterial smooth muscle cell proliferation during PH.http://www.mdpi.com/2076-3921/8/3/56NADPH oxidasepulmonary arterial smooth musclereactive oxygen species |
| spellingShingle | John C. Huetsch Karthik Suresh Larissa A. Shimoda Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension Antioxidants NADPH oxidase pulmonary arterial smooth muscle reactive oxygen species |
| title | Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension |
| title_full | Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension |
| title_fullStr | Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension |
| title_full_unstemmed | Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension |
| title_short | Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension |
| title_sort | regulation of smooth muscle cell proliferation by nadph oxidases in pulmonary hypertension |
| topic | NADPH oxidase pulmonary arterial smooth muscle reactive oxygen species |
| url | http://www.mdpi.com/2076-3921/8/3/56 |
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