A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio
Dyslipidemia is a major public health problem, and therefore, it is important to develop dietary strategies to diminish the prevalence of this disorder. It was recently reported that diet may play an important role in triggering insulin resistance by interacting with genetic variants at the CAPN10 g...
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| Format: | Article |
| Language: | English |
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Arán Ediciones, S. L.
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| Series: | Nutrición Hospitalaria |
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| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001000027&lng=en&tlng=en |
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| author | Martha Guevara-Cruz Nimbe Torres Armando R. Tovar M Elizabeth Tejero Ashley Castellanos-Jankiewicz Laura del Bosque-Plata |
| author_facet | Martha Guevara-Cruz Nimbe Torres Armando R. Tovar M Elizabeth Tejero Ashley Castellanos-Jankiewicz Laura del Bosque-Plata |
| author_sort | Martha Guevara-Cruz |
| collection | DOAJ |
| description | Dyslipidemia is a major public health problem, and therefore, it is important to develop dietary strategies to diminish the prevalence of this disorder. It was recently reported that diet may play an important role in triggering insulin resistance by interacting with genetic variants at the CAPN10 gene locus in patients with metabolic syndrome. Nonetheless, it remains unknown whether genetic variants of genes involved in the development of type 2 diabetes are associated with variations in high-density lipoprotein cholesterol (HDL-C). The study used a single-center, prospective, cohort design. Here, we assessed the effect of four variants of the CAPN10 gene on HDL-C levels in response to a soy protein and soluble fiber dietary portfolio in subjects with dyslipidemia. In 31 Mexican dyslipidemic individuals, we analyzed four CAPN10 gene variants (rs5030952, rs2975762, rs3792267, and rs2975760) associated with type 2 diabetes. Subjects with the GG genotype of the rs2975762 variant of the CAPN10 gene were better responders to dietary intervention, showing increased HDL-C concentrations from the first month of treatment. HDL-C concentrations in participants with the wild type genotype increased by 17.0%, whereas the HDL-C concentration in subjects with the variant genotypes increased by only 3.22% (p = 0.03); the low-density lipoprotein cholesterol levels of GG carriers tended to decrease (-12.6%). These results indicate that Mexican dyslipidemic carriers of the rs2975762-GG genotype are better responders to this dietary intervention. |
| first_indexed | 2024-04-13T09:13:02Z |
| format | Article |
| id | doaj.art-1da95052277442978c456fd650ee918e |
| institution | Directory Open Access Journal |
| issn | 0212-1611 |
| language | English |
| last_indexed | 2024-04-13T09:13:02Z |
| publisher | Arán Ediciones, S. L. |
| record_format | Article |
| series | Nutrición Hospitalaria |
| spelling | doaj.art-1da95052277442978c456fd650ee918e2022-12-22T02:52:50ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-161130367167710.3305/nh.2014.30.3.7611S0212-16112014001000027A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolioMartha Guevara-Cruz0Nimbe Torres1Armando R. Tovar2M Elizabeth Tejero3Ashley Castellanos-Jankiewicz4Laura del Bosque-Plata5Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránInstituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránInstituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránInstituto Nacional de Medicina GenómicaInstituto Nacional de Medicina GenómicaInstituto Nacional de Medicina GenómicaDyslipidemia is a major public health problem, and therefore, it is important to develop dietary strategies to diminish the prevalence of this disorder. It was recently reported that diet may play an important role in triggering insulin resistance by interacting with genetic variants at the CAPN10 gene locus in patients with metabolic syndrome. Nonetheless, it remains unknown whether genetic variants of genes involved in the development of type 2 diabetes are associated with variations in high-density lipoprotein cholesterol (HDL-C). The study used a single-center, prospective, cohort design. Here, we assessed the effect of four variants of the CAPN10 gene on HDL-C levels in response to a soy protein and soluble fiber dietary portfolio in subjects with dyslipidemia. In 31 Mexican dyslipidemic individuals, we analyzed four CAPN10 gene variants (rs5030952, rs2975762, rs3792267, and rs2975760) associated with type 2 diabetes. Subjects with the GG genotype of the rs2975762 variant of the CAPN10 gene were better responders to dietary intervention, showing increased HDL-C concentrations from the first month of treatment. HDL-C concentrations in participants with the wild type genotype increased by 17.0%, whereas the HDL-C concentration in subjects with the variant genotypes increased by only 3.22% (p = 0.03); the low-density lipoprotein cholesterol levels of GG carriers tended to decrease (-12.6%). These results indicate that Mexican dyslipidemic carriers of the rs2975762-GG genotype are better responders to this dietary intervention.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001000027&lng=en&tlng=enCalpain-10polymorphismdietary portfoliohypercholesterolemicdyslipidemia |
| spellingShingle | Martha Guevara-Cruz Nimbe Torres Armando R. Tovar M Elizabeth Tejero Ashley Castellanos-Jankiewicz Laura del Bosque-Plata A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio Nutrición Hospitalaria Calpain-10 polymorphism dietary portfolio hypercholesterolemic dyslipidemia |
| title | A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio |
| title_full | A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio |
| title_fullStr | A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio |
| title_full_unstemmed | A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio |
| title_short | A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio |
| title_sort | genetic variant of the capn10 gene in mexican subjects with dyslipidemia is associated with increased hdl cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio |
| topic | Calpain-10 polymorphism dietary portfolio hypercholesterolemic dyslipidemia |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001000027&lng=en&tlng=en |
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