ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals
Abstract This study investigated the cytotoxic effects of oxidative stress (OS), high mobility group box 1 (HMGB1), ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs), and neuropathology associated with coenurus cerebralis (Taenia multiceps). ADAMTS-13, HMGB1, glutathione reduct...
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44376-0 |
| _version_ | 1797560242811174912 |
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| author | Gungor Cagdas Dincel Orhan Yavuz Serkan Yildirim Ebtesam M. Al-Olayan Saeed El-Ashram |
| author_facet | Gungor Cagdas Dincel Orhan Yavuz Serkan Yildirim Ebtesam M. Al-Olayan Saeed El-Ashram |
| author_sort | Gungor Cagdas Dincel |
| collection | DOAJ |
| description | Abstract This study investigated the cytotoxic effects of oxidative stress (OS), high mobility group box 1 (HMGB1), ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs), and neuropathology associated with coenurus cerebralis (Taenia multiceps). ADAMTS-13, HMGB1, glutathione reductase (GR), copper/zinc superoxide dismutase (Cu/Zn SOD), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) expression levels were studied. The study found that ADAMTS-13 (P < 0.005), HMGB1 (P < 0.005), GR (P < 0.005), Cu/Zn SOD (P < 0.005), and 8-OHdG (P < 0.005) levels were significantly higher in T. multiceps (c. cerebralis)-infected animals compared to healthy control animals. This study's most important finding was that HMGB1 up-regulation in neurons, endothelial cells, and glial cells can directly cause brain parenchymal destruction and that HMGB1-mediated oxidative stress plays a crucial role in the neuropathogenesis of coenurosis. The results also showed that increased levels of ADAMTS-13 may play a pivotal role in regulating and protecting the blood–brain barrier integrity and neuroprotection. These findings also suggest that ADAMTS-13 and HMGB1 compete in the prevention or formation of microthrombi, which was regarded as a remarkable finding. ADAMTS-13 and HMGB1 are valuable biomarkers for disease risk assessment, estimating host neuropathy following T. multiceps (c. cerebralis) exposure, and providing a new therapeutic target. This is the first study to show that HMGB1 and ADAMTS-13 are expressed in reactive cells and are associated with neuroimmunopathology in coenurosis. |
| first_indexed | 2024-03-10T17:56:42Z |
| format | Article |
| id | doaj.art-1daaf90a3bf349ec8b6569f453bfbb2f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:56:42Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1daaf90a3bf349ec8b6569f453bfbb2f2023-11-20T09:09:48ZengNature PortfolioScientific Reports2045-23222023-10-0113111410.1038/s41598-023-44376-0ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animalsGungor Cagdas Dincel0Orhan Yavuz1Serkan Yildirim2Ebtesam M. Al-Olayan3Saeed El-Ashram4Eskil Vocational School, Laboratory and Veterinary Science, Aksaray UniversityDepartment of Pathology, Faculty of Veterinary Medicine, Aksaray UniversityDepartment of Pathology, Faculty of Veterinary Medicine, Atatürk UniversityDepartment of Zoology, College of Science, King Saud UniversityZoology Department, Faculty of Science, Kafrelsheikh UniversityAbstract This study investigated the cytotoxic effects of oxidative stress (OS), high mobility group box 1 (HMGB1), ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs), and neuropathology associated with coenurus cerebralis (Taenia multiceps). ADAMTS-13, HMGB1, glutathione reductase (GR), copper/zinc superoxide dismutase (Cu/Zn SOD), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) expression levels were studied. The study found that ADAMTS-13 (P < 0.005), HMGB1 (P < 0.005), GR (P < 0.005), Cu/Zn SOD (P < 0.005), and 8-OHdG (P < 0.005) levels were significantly higher in T. multiceps (c. cerebralis)-infected animals compared to healthy control animals. This study's most important finding was that HMGB1 up-regulation in neurons, endothelial cells, and glial cells can directly cause brain parenchymal destruction and that HMGB1-mediated oxidative stress plays a crucial role in the neuropathogenesis of coenurosis. The results also showed that increased levels of ADAMTS-13 may play a pivotal role in regulating and protecting the blood–brain barrier integrity and neuroprotection. These findings also suggest that ADAMTS-13 and HMGB1 compete in the prevention or formation of microthrombi, which was regarded as a remarkable finding. ADAMTS-13 and HMGB1 are valuable biomarkers for disease risk assessment, estimating host neuropathy following T. multiceps (c. cerebralis) exposure, and providing a new therapeutic target. This is the first study to show that HMGB1 and ADAMTS-13 are expressed in reactive cells and are associated with neuroimmunopathology in coenurosis.https://doi.org/10.1038/s41598-023-44376-0 |
| spellingShingle | Gungor Cagdas Dincel Orhan Yavuz Serkan Yildirim Ebtesam M. Al-Olayan Saeed El-Ashram ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals Scientific Reports |
| title | ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals |
| title_full | ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals |
| title_fullStr | ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals |
| title_full_unstemmed | ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals |
| title_short | ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals |
| title_sort | adamts 13 and hmgb1 induced oxidative stress in taenia multiceps infected animals |
| url | https://doi.org/10.1038/s41598-023-44376-0 |
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