Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

We have previously shown the delivery of phosphatase of regenerating liver-1 (PRL-1) to the immunological synapse (IS) and proposed a regulatory role of the catalytic activity of PRLs (PRL-1, PRL-2 and PRL-3) in antigen-induced IL-2 production. Nonetheless, the expression in T cells and delivery to...

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Bibliographic Details
Main Authors: Oscar Aguilar-Sopeña, Sara Hernández-Pérez, Sergio Alegre-Gómez, Patricia Castro-Sánchez, Alba Iglesias-Ceacero, John S. Lazo, Pedro Roda-Navarro
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
immunological synapse
endosomal compartment
phosphatase of regenerating liver
TCR early signaling
cytokine production
Online Access:https://www.mdpi.com/1422-0067/21/7/2530

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